F
Francis R. Carbone
Researcher at University of Melbourne
Publications - 216
Citations - 37352
Francis R. Carbone is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 83, co-authored 213 publications receiving 35098 citations. Previous affiliations of Francis R. Carbone include Cooperative Research Centre & Washington University in St. Louis.
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Journal Article
Conventional CD8α+ dendritic cells are generally involved in priming CTL immunity to viruses
Gabrielle T. Belz,Christopher M. Smith,Daniel Eichner,Ken Shortman,Gunasegaran Karupiah,Francis R. Carbone,William R. Heath +6 more
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Structure-activity studies of melatonin analogues in prepubertal male rats.
David J. Kennaway,Helmut M. Hügel,Sally R. M. Clarke,A Tjandra,D W Johnson,P. Royles,H. Webb,Francis R. Carbone +7 more
TL;DR: Although the hypothesis that melatonin acts as a prohormone and that the ring schism metabolites (kynurenamines) mediate many of the effects attributable to melatonin could not be confirmed, modification of the melatonin structure by lengthening the acrylamide side chain or by replacing the 5 methoxy function with fluorine resulted in loss of biological potency.
Journal Article
TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity
TL;DR: The results suggest that preferential use of one TCR subunit can restrict the level of diversity in the other chain due to interchain interactions involving J-derived sequences.
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The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis.
Jane Li,Jane Li,Rangsima Reantragoon,Rangsima Reantragoon,Lyudmila Kostenko,Alexandra J. Corbett,George Varigos,Francis R. Carbone +7 more
TL;DR: The expression of skin‐tropic molecules on human skin MAIT cells at steady state is described and their contribution to various dermatoses with known T‐cell involvement is investigated.
Journal ArticleDOI
The Structure of H-2Kb and Kbm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance
Andrew I. Webb,Natalie A. Borg,Michelle A. Dunstone,Lars Kjer-Nielsen,Travis Clarke Beddoe,James McCluskey,Francis R. Carbone,Stephen P. Bottomley,Marie-Isabel Aguilar,Anthony W. Purcell,Jamie Rossjohn +10 more
TL;DR: An analysis of all known TCR/MHC complexes reveals that Arg62 invariably interacts with the TCR CDR1α loop, and Arg62 appears to function as a conformational switch that may govern T cell selection and protective immunity.