F
Francisco J. Agosto-Perez
Researcher at Ohio State University
Publications - 6
Citations - 1343
Francisco J. Agosto-Perez is an academic researcher from Ohio State University. The author has contributed to research in topics: Promoter & Mammalian promoter database. The author has an hindex of 6, co-authored 6 publications receiving 1257 citations. Previous affiliations of Francisco J. Agosto-Perez include Wistar Institute.
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Journal ArticleDOI
A MicroRNA Signature of Hypoxia
Ritu Kulshreshtha,Manuela Ferracin,Sylwia E. Wojcik,Ramiro Garzon,Hansjuerg Alder,Francisco J. Agosto-Perez,Ramana V. Davuluri,Chang Gong Liu,Carlo M. Croce,Massimo Negrini,George A. Calin,Mircea Ivan +11 more
TL;DR: A functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression is demonstrated for the first time and selected microRNAs decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation.
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Genome-wide analysis of core promoter elements from conserved human and mouse orthologous pairs.
Victor X. Jin,Gregory A. C. Singer,Francisco J. Agosto-Perez,Sandya Liyanarachchi,Ramana V. Davuluri +4 more
TL;DR: The results demonstrate that DNA sequence conservation can greatly improve the identification of functional core promoter elements in the human genome and underscores the importance of synergistic occurrence of two or morecore promoter elements.
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An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
Huaxia Qin,Michael W.Y. Chan,Michael W.Y. Chan,Sandya Liyanarachchi,Curtis Balch,Dustin Potter,Irene P. Joseph Souriraj,Alfred S. L. Cheng,Alfred S. L. Cheng,Francisco J. Agosto-Perez,Elena Nikonova,Pearlly S. Yan,Huey-Jen Lin,Kenneth P. Nephew,Joel H. Saltz,Louise C. Showe,Tim H M Huang,Ramana V. Davuluri,Ramana V. Davuluri +18 more
TL;DR: Together, the computational results further the understanding of the interactions between SMAD and other transcription factors at specific target promoters, and provide the basis for more targeted experimental verification of the co-regulatory modules.
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Genome-wide mapping of RNA Pol-II promoter usage in mouse tissues by ChIP-seq
Hao Sun,Jiejun Wu,Priyankara Wickramasinghe,Sharmistha Pal,Ravi Gupta,Anirban Bhattacharyya,Francisco J. Agosto-Perez,Louise C. Showe,Tim H M Huang,Ramana V. Davuluri +9 more
TL;DR: The promoter annotations and ChIP-seq data presented here will aid ongoing efforts of characterizing gene regulatory regions in mammalian genomes.
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Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
Benjamin Rodriguez,Alfred S. L. Cheng,Pearlly S. Yan,Dustin Potter,Francisco J. Agosto-Perez,Charles L. Shapiro,Tim H M Huang +6 more
TL;DR: The epigenetic analysis has found that hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients.