R
Ritu Kulshreshtha
Researcher at Indian Institute of Technology Delhi
Publications - 56
Citations - 3731
Ritu Kulshreshtha is an academic researcher from Indian Institute of Technology Delhi. The author has contributed to research in topics: microRNA & Gene expression profiling. The author has an hindex of 20, co-authored 48 publications receiving 3185 citations. Previous affiliations of Ritu Kulshreshtha include Jawaharlal Nehru University & Tufts University.
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Journal ArticleDOI
A MicroRNA Signature of Hypoxia
Ritu Kulshreshtha,Manuela Ferracin,Sylwia E. Wojcik,Ramiro Garzon,Hansjuerg Alder,Francisco J. Agosto-Perez,Ramana V. Davuluri,Chang Gong Liu,Carlo M. Croce,Massimo Negrini,George A. Calin,Mircea Ivan +11 more
TL;DR: A functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression is demonstrated for the first time and selected microRNAs decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation.
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MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress
TL;DR: Hypoxia-inducible miR-210 andmiR-373 play roles in modulating the expression levels of key proteins involved in the HDR and NER pathways, providing new mechanistic insight into the effect of hypoxia on DNA repair and genetic instability in cancer.
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An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210
Pasquale Fasanaro,Simona Greco,Maria Lorenzi,Mario Pescatori,Maura Brioschi,Ritu Kulshreshtha,Ritu Kulshreshtha,Cristina Banfi,Andrew P. Stubbs,George A. Calin,Mircea Ivan,Maurizio C. Capogrossi,Fabio Martelli +12 more
TL;DR: An integrated strategy for large-scale identification of new miR-210 targets by combining transcriptomics and proteomics with bioinformatic approaches is described and a new role of this miRNA is predicted in RNA processing, DNA binding, development, membrane trafficking, and amino acid catabolism is predicted.
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A microRNA component of the hypoxic response
TL;DR: The emerging roles of HRMs in oxygen deprivation in cancer context are discussed and preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis.
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Hypoxia response and microRNAs: no longer two separate worlds.
TL;DR: This work has shown a role for hypoxia in the regulation of miR expression and the ongoing search for miR‐210 targets and potential targets for clinical applications is still an ongoing search.