Francisco Sanchez-Vega

TL;DR: NPA and specific pathway alterations are associated with clinicopathologic features in patients with surgically resected lung adenocarcinoma and Cell cycle, Hippo, TGFβ, and p53 pathway alterationsAre associated with poor DFS, and NPA is an independent risk factor forpoor DFS in this cohort.

TL;DR: In this paper, the authors investigated clinicopathologic and genomic features of lung-only melanomas with the goal to clarify their site of origin, and found that the clinical and pathologic features of solitary melanomas, especially those with large size and epithelioid morphology, closely mimicked primary lung carcinomas, highlighting a major potential for misdiagnosis.

TL;DR: In this paper, a Cox proportional hazards model was constructed for TTF using driver group and clinical variables, and nine driver groups varied by clinical presentation and mutational burden, with worse outcomes for NRAS Q61 and BRAF V600 versus NF1 or other alterations.

TL;DR: In this article , the authors analyzed genomic and transcriptomic profiles of 738 untreated rectal cancers and identified biomarkers of response that could inform patient selection for non-operative treatment strategies.

TL;DR: Sleeping Beauty (SB) transposon mutagenesis was used to identify events that cooperate with HrasG12V in thyroid tumor development and provided strong functional support for genetic disruptions in these pathways in RAS-induced thyroid tumor progression.