H
Havish S. Kantheti
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 6
Citations - 2259
Havish S. Kantheti is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 3, co-authored 5 publications receiving 1334 citations. Previous affiliations of Havish S. Kantheti include University of Texas at Dallas.
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Journal ArticleDOI
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega,Marco Mina,Joshua Armenia,Walid K. Chatila,Augustin Luna,Konnor La,Sofia Dimitriadoy,David L. Liu,Havish S. Kantheti,Sadegh Saghafinia,Debyani Chakravarty,Foysal Daian,Qingsong Gao,Matthew H. Bailey,Wen-Wei Liang,Steven M. Foltz,Ilya Shmulevich,Li Ding,Zachary J. Heins,Angelica Ochoa,Benjamin Gross,Jianjiong Gao,Hongxin Zhang,Ritika Kundra,Cyriac Kandoth,Istemi Bahceci,Leonard Dervishi,Ugur Dogrusoz,Wanding Zhou,Hui Shen,Peter W. Laird,Gregory P. Way,Casey S. Greene,Han Liang,Yonghong Xiao,Chen Wang,Antonio Iavarone,Alice H. Berger,Trever G. Bivona,Alexander J. Lazar,Gary D. Hammer,Thomas J. Giordano,Lawrence N. Kwong,Grant A. McArthur,Chenfei Huang,Aaron D. Tward,Mitchell J. Frederick,Frank McCormick,Matthew Meyerson,Eliezer M. Van Allen,Andrew D. Cherniack,Giovanni Ciriello,Chris Sander,Nikolaus Schultz +53 more
TL;DR: This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity.
Journal ArticleDOI
Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Julija Hmeljak,Francisco Sanchez-Vega,Katherine A. Hoadley,Juliann Shih,Chip Stewart,David I. Heiman,Patrick S. Tarpey,Ludmila Danilova,Esther Drill,Ewan A. Gibb,Reanne Bowlby,Rupa S. Kanchi,Hatice U. Osmanbeyoglu,Yoshitaka Sekido,Jumpei Takeshita,Yulia Newton,Kiley Graim,Manaswi Gupta,Lixia Diao,David L Gibbs,Vesteinn Thorsson,Lisa Iype,Havish S. Kantheti,David T. Severson,Gloria Ravegnini,Patrice Desmeules,Achim A. Jungbluth,William D. Travis,Sanja Dacic,Lucian R. Chirieac,Françoise Galateau-Sallé,Junya Fujimoto,Aliya N. Husain,Henrique César Santejo Silveira,Valerie W. Rusch,Robert C. Rintoul,Harvey I. Pass,Hedy L. Kindler,Marjorie G. Zauderer,David J. Kwiatkowski,Raphael Bueno,Anne S. Tsao,Jenette Creaney,Tara M. Lichtenberg,Kristen M. Leraas,Jay Bowen,Ina Felau,Jean C. Zenklusen,Rehan Akbani,Andrew D. Cherniack,Lauren Averett Byers,Michael S. Noble,Jonathan A. Fletcher,Gordon Robertson,Ronglai Shen,Hiroyuki Aburatani,Bruce W. S. Robinson,Peter J. Campbell,Marc Ladanyi +58 more
TL;DR: A comprehensive integrated genomic study of 74 MPMs provided a deeper understanding of histology-independent determinants of aggressive behavior, defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expression of the immune-checkpoint gene VISTA in epithelioid MPM.
Journal ArticleDOI
Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas.
Alexander N. Shoushtari,Alexander N. Shoushtari,Walid K. Chatila,Walid K. Chatila,Arshi Arora,Francisco Sanchez-Vega,Havish S. Kantheti,Jorge A. Rojas Zamalloa,Penina Krieger,Margaret K. Callahan,Margaret K. Callahan,Allison Betof Warner,Allison Betof Warner,Michael A. Postow,Michael A. Postow,Parisa Momtaz,Parisa Momtaz,Suresh G. Nair Md,Charlotte E. Ariyan,Christopher A. Barker,Mary S. Brady,Daniel G. Coit,Neal Rosen,Neal Rosen,Paul B. Chapman,Paul B. Chapman,Klaus J. Busam,David B. Solit,David B. Solit,Katherine S. Panageas,Jedd D. Wolchok,Jedd D. Wolchok,Nikolaus Schultz +32 more
TL;DR: In this paper, a Cox proportional hazards model was constructed for TTF using driver group and clinical variables, and nine driver groups varied by clinical presentation and mutational burden, with worse outcomes for NRAS Q61 and BRAF V600 versus NF1 or other alterations.
Proceedings ArticleDOI
Abstract 3302: The molecular landscape of oncogenic signaling pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega,Marco Mina,Joshua Armenia,Walid K. Chatila,Augustin Luna,Konnor La,Sofia Dimitriadoy,David L. Liu,Havish S. Kantheti,Zachary J. Heins,Angelica Ochoa,Benjamin Gross,Jianjiong Gao,Hongxin Zhang,Ritika Kundra,Cyriac Kandoth,Istemi Bahceci,Leonard Dervishi,Ugur Dogrusoz,Wanding Zhou,Hui Shen,Peter W. Laird,Alice H. Berger,Trever G. Bivona,Alexander J. Lazar,Gary D. Hammer,Thomas J. Giordano,Lawrence N. Kwong,Grant A. McArthur,Chenfei Huang,Mitchell J. Frederick,Frank McCormick,Matthew Meyerson,Eliezer M. Van Allen,Andrew D. Cherniack,Giovanni Ciriello,Chris Sander,Nikolaus Schultz +37 more
TL;DR: This work delineates the full landscape of oncogenic alterations in mitogenic signaling pathways across cancer, and the pathway templates as well as the richly annotated data set that it provides will constitute an invaluable public resource for future use by the cancer genomics and precision oncology communities.
The molecular landscape of oncogenic signaling pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega,Marco Mina,Joshua Armenia,Walid K. Chatila,Augustin Luna,Konnor La,Sofia Dimitriadoy,David L. Liu,Havish S. Kantheti,Zachary J. Heins,Angelica Ochoa,Benjamin Gross,Jianjiong Gao,Hongxin Zhang,Ritika Kundra,Cyriac Kandoth,Istemi Bahceci,Leonard Dervishi,Ugur Dogrusoz,Wanding Zhou,Hui Shen,Peter W. Laird,Alice H. Berger,Trever G. Bivona,Alexander J. Lazar,Gary D. Hammer,Thomas P. Giordano,Lawrence N. Kwong,Grant A. McArthur,Chenfei Huang,Mitchell J. Frederick,Frank McCormick,Matthew Meyerson,Eliezer M. Van Allen,Andrew D. Cherniack,Giovanni Ciriello,Chris Sander,Nikolaus Schultz +37 more