F
Francisco Sanchez-Vega
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 115
Citations - 20975
Francisco Sanchez-Vega is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 36, co-authored 84 publications receiving 13474 citations. Previous affiliations of Francisco Sanchez-Vega include Washington University in St. Louis & National Institutes of Health.
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Pan-cancer analysis of whole genomes
Peter J. Campbell,Gad Getz,Jan O. Korbel,Joshua M. Stuart,Jennifer L. Jennings,Lincoln Stein,Lincoln Stein,Marc D. Perry,Hardeep K. Nahal-Bose,B. F. Francis Ouellette,Constance H. Li,Esther Rheinbay,G. Petur Nielsen,Dennis C. Sgroi,Chin-Lee Wu,William C. Faquin,Vikram Deshpande,Paul C. Boutros,A. J. Lazar,Katherine A. Hoadley,David N. Louis,L. Jonathan Dursi,Christina K. Yung,Matthew A. Bailey,Gordon Saksena,Keiran Raine,Ivo Buchhalter,Ivo Buchhalter,Kortine Kleinheinz,Matthias Schlesner,Junjun Zhang,Wenyi Wang,D Wheeler,Li Ding,Jared T. Simpson,Jared T. Simpson,Brian O'Connor,Sergei Yakneen,Kyle Ellrott,Naoki Miyoshi,Adam Butler,Romina Royo,Solomon Shorser,Miguel Vazquez,Tobias Rausch,Grace Tiao,Sebastian M. Waszak,Bernardo Rodriguez-Martin,Suyash Shringarpure,Dai-Ying Wu,German Demidov,Olivier Delaneau,Shuto Hayashi,Seiya Imoto,Nina Habermann,Ayellet V. Segrè,Erik Garrison,Andy Cafferkey,Eva G. Alvarez,Jose Maria Heredia-Genestar,Francesc Muyas,Oliver Drechsel,Alicia L. Bruzos,Javier Temes,Jorge Zamora,Adrian Baez-Ortega,Hyung Lae Kim,R. Jay Mashl,Kai Ye,Anthony DiBiase,Kuan-lin Huang,Ivica Letunic,Michael D. McLellan,Steven Newhouse,Tal Shmaya,Sushant Kumar,David C. Wedge,Mark H. Wright,Venkata Yellapantula,Mark Gerstein,Ekta Khurana,Tomas Marques-Bonet,Arcadi Navarro,Carlos Bustamante,Reiner Siebert,Hidewaki Nakagawa,Douglas F. Easton,Stephan Ossowski,Jose M. C. Tubio,Francisco M. De La Vega,Xavier Estivill,Denis Yuen,George L. Mihaiescu,Larsson Omberg,Vincent Ferretti,Radhakrishnan Sabarinathan,Oriol Pich,Abel Gonzalez-Perez,Amaro N. Taylor Weiner,Matthew Fittall,Jonas Demeulemeester,Maxime Tarabichi,Nicola D. Roberts,Peter Van Loo,Isidro Cortes-Ciriano,Lara Urban,Peter J. Park,Bin Zhu,Esa Pitkänen,Yang Li,Natalie Saini,Leszek J. Klimczak,Joachim Weischenfeldt,Nikos Sidiropoulos,Ludmil B. Alexandrov,Raquel Rabionet,Geòrgia Escaramís,Mattia Bosio,Aliaksei Holik,Hana Susak,Aparna Prasad,Serap Erkek,Claudia Calabrese,Benjamin Raeder,Eoghan D. Harrington,Simon Mayes,Daniel J. Turner,Sissel Juul,Steven A. Roberts,Lei Song,Roelof Koster,Lisa Mirabello,Xing Hua,Tomas Tanskanen,Marta Tojo,Jieming Chen,Lauri A. Aaltonen,Gunnar Rätsch,Roland F. Schwarz,Atul J. Butte,Alvis Brazma,Stephen J. Chanock,Nilanjan Chatterjee,Oliver Stegle,Olivier Harismendy,G. Steven Bova,Dmitry A. Gordenin,David Haan,Lina Sieverling,Lars Feuerbach,Don Chalmers,Yann Joly,Bartha Maria Knoppers,Fruzsina Molnár-Gábor,Mark M. Phillips,Adrian Thorogood,David Townend,Mary Goldman,Nuno A. Fonseca,Qian Xiang,Brian Craft,Elena Piñeiro-Yáñez,Alfonso Munoz,Robert Petryszak,Anja Füllgrabe,Fatima Al-Shahrour,Maria Keays,David Haussler,John N. Weinstein,Wolfgang Huber,Alfonso Valencia,Irene Papatheodorou,Jingchun Zhu,Yu Fan,David Torrents,Matthias Bieg,Ken Chen,Zechen Chong,Kristian Cibulskis,Roland Eils,Robert S. Fulton,Josep L. Gelpi,Santiago Gonzalez,Ivo Gut,Faraz Hach,Michael Heinold,Taobo Hu,Vincent Huang,Barbara Hutter,Natalie Jaeger,Jongsun Jung,Yogesh Kumar,Christopher M. Lalansingh,Ignaty Leshchiner,Dimitri Livitz,Eric Z. Ma,Yosef E. Maruvka,Ana Milovanovic,Morten Muhlig Nielsen,Nagarajan Paramasivam,Jakob Skou Pedersen,Montserrat Puiggròs,S. Cenk Sahinalp,Iman Sarrafi,Chip Stewart,Miranda D. Stobbe,Jeremiah Wala,Jiayin Wang,Michael C. Wendl,Johannes Werner,Zhenggang Wu,Hong Xue,Takafumi N. Yamaguchi,Venkata Yellapantula,Brandi N. Davis-Dusenbery,Robert L. Grossman,Young-Wook Kim,Michael C. Heinold,Jonathan Hinton,David Jones,Andrew Menzies,Lucy Stebbings,Julian M. Hess,Mara Rosenberg,Andrew Dunford,Manaswi Gupta,Marcin Imielinski,Matthew Meyerson,Rameen Beroukhim,Juri Reimand,Priyanka Dhingra,Francesco Favero,Stefan C. Dentro,Jeff Wintersinger,Vasilisa A. Rudneva,Ji Wan Park,Eun Pyo Hong,Seong Gu Heo,André Kahles,Kjong-Van Lehmann,Cameron M. Soulette,Yuichi Shiraishi,Fenglin Liu,Yao He,Deniz Demircioğlu,Natalie R. Davidson,Liliana Greger,Siliang Li,Dongbing Liu,Stefan G. Stark,Fan Zhang,Samirkumar B. Amin,Peter Bailey,A. Chateigner,Milana Frenkel-Morgenstern,Yong Hou,Matthew R. Huska,Helena Kilpinen,Fabien C. Lamaze,Chang Li,Xiaobo Li,Xinyue Li,Xingmin Liu,Maximillian G. Marin,Julia Markowski,Tannistha Nandi,Akinyemi I. Ojesina,Qiang Pan-Hammarström,Peter J. Park,Chandra Sekhar Pedamallu,Hong Su,Patrick Tan,Bin Tean Teh,Jian Wang,Heng Xiong,Chen Ye,Xiuqing Zhang,Liangtao Zheng,Shida Zhu,Philip Awadalla,Chad J. Creighton,Kui Wu,Huanming Yang,Jonathan Göke,Zemin Zhang,Angela N. Brooks,Inigo Martincorena,Carlota Rubio-Perez,Malene Juul,Steven E. Schumacher,Ofer Shapira,David Tamborero,Loris Mularoni,Henrik Hornshøj,Jordi Deu-Pons,Ferran Muiños,Johanna Bertl,Qianyun Guo,Wojciech Bazant,Elisabet Barrera,Sultan T. Al-Sedairy,Axel Aretz,Cindy Bell,Miguel Betancourt,Christiane Buchholz,Fabien Calvo,Christine Chomienne,Michael Dunn,Stuart Edmonds,Eric D. Green,Shailja Gupta,Carolyn M. Hutter,Karine Jegalian,Nic Jones,Youyong Lu,Hitoshi Nakagama,Gerd Nettekoven,Laura Planko,David Scott,Tatsuhiro Shibata,Kiyo Shimizu,Michael R. Stratton,Takashi Yugawa,Giampaolo Tortora,K. VijayRaghavan,Jean C. Zenklusen,Brice Aminou,Javier Bartolome,Keith A. Boroevich,Rich Boyce,Alex Buchanan,Niall J. Byrne,Zhaohong Chen,Sung-Hoon Cho,Wan Choi,Peter Clapham,Michelle Dow,L. J. Dursi,Juergen Eils,Claudiu Farcas,Nodirjon Fayzullaev,Paul Flicek,Allison Heath,Oliver Hofmann,Jongwhi H. Hong,Thomas J. Hudson,Daniel Huebschmann,Sinisa Ivkovic,Seung-Hyup Jeon,Wei Jiao,Rolf Kabbe,Jules Kerssemakers,Hyung Hwan Kim,Jihoon Kim,Michael Koscher,Antonios Koures,Milena Kovacevic,Chris Lawerenz,Jia Liu,Sanja Mijalkovic,Ana Mijalkovic Mijalkovic-Lazic,Satoru Miyano,Mia Nastic,Jonathan Nicholson,David Ocana,Kazuhiro Ohi,Lucila Ohno-Machado,Todd Pihl,Manuel Prinz,Petar Radovic,Charles Short,Heidi J. Sofia,Jonathan Spring,Adam J Struck,Nebojsa Tijanic,David Vicente,Zhining Wang,Ashley Williams,Young-Choon Woo,Adam Wright,Liming Yang,Mark P. Hamilton,Todd A. Johnson,Abdullah Kahraman,Manolis Kellis,Paz Polak,Richard C Sallari,Nasa Sinnott-Armstrong,Christian von Mering,Sergi Beltran,Daniela S. Gerhard,Marta Gut,Jean-Rémi Trotta,Justin P. Whalley,Beifang Niu,Shadrielle Melijah G. Espiritu,Shengjie Gao,Yi Huang,Christopher M. Lalansingh,Jon W. Teague,Federico Abascal,Gary D. Bader,Pratiti Bandopadhayay,Jonathan Barenboim,Søren Brunak,Joana Carlevaro Fita,Dimple Chakravarty,Calvin Wing Yiu Chan,Jung Kyoon Choi,Klev Diamanti,J. Lynn Fink,Joan Frigola,Carlo Gambacorti-Passerini,Dale W. Garsed,Nicholas J. Haradhvala,Arif Harmanci,Mohamed Helmy,Carl Herrmann,Asger Hobolth,Ermin Hodzic,Chen Hong,Keren Isaev,Jose M. G. Izarzugaza,Rory Johnson,Randi Istrup Juul,Jaegil Kim,Jong Kyoung Kim,Jan Komorowski,Andrés Lanzós,Erik Larsson,Dong-Hoon Lee,Shantao Li,Xiaotong Li,Ziao Lin,Eric Minwei Liu,Lucas Lochovsky,Shaoke Lou,Tobias Madsen,Kathleen Marchal,Alexander Martinez Fundichely,Patrick McGillivray,William Meyerson,Marta Paczkowska,Keunchil Park,Kiejung Park,Tirso Pons,Sergio Pulido-Tamayo,Iker Reyes Salazar,Matthew A. Reyna,Mark A. Rubin,Leonidas Salichos,Chris Sander,Steven E. Schumacher,Mark Shackleton,Ciyue Shen,Raunak Shrestha,Shimin Shuai,Tatsuhiko Tsunoda,Husen M. Umer,Liis Uusküla-Reimand,Lieven Verbeke,Claes Wadelius,Lina Wadi,Jonathan Warrell,Guanming Wu,Jun Yu,Jing Zhang,Xuanping Zhang,Yan Zhang,Zhongming Zhao,Lihua Zou,Michael S. Lawrence,Benjamin J. Raphael,David Craft,Mary J. Goldman,Hiroyuki Aburatani,Hans Binder,Huy Q. Dinh,Simon Heath,Steve Hoffmann,Charles D. Imbusch,Helene Kretzmer,Peter W. Laird,José I. Martín-Subero,Genta Nagae,Hui Shen,Qi Wang,Dieter Weichenhan,Wanding Zhou,Benjamin P. Berman,Benedikt Brors,Christoph Plass,Kadir C. Akdemir,David D.L. Bowtell,Kathleen H. Burns,John P. Busanovich,Kin Chan,Ana Dueso-Barroso,Paul A.W. Edwards,Dariush Etemadmoghadam,James E. Haber,David T.W. Jones,Young Seok Ju,Marat D. Kazanov,Youngil Koh,Kiran Kumar,Eunjung Lee,June Koo Lee,Andy G. Lynch,Geoff Macintyre,Florian Markowetz,Fabio C. P. Navarro,John V. Pearson,Karsten Rippe,Ralph Scully,Izar Villasante,Nicola Waddell,Lixing Yang,Xiaotong Yao,Sung-Soo Yoon,Cheng-Zhong Zhang,Erik N. Bergstrom,Arnoud Boot,Kyle R. Covington,Akihiro Fujimoto,Mi Ni Huang,S. M. Ashiqul Islam,John R. McPherson,Sandro Morganella,Ville Mustonen,Alvin Wei Tian Ng,Stephenie D. Prokopec,Ignacio Vázquez-García,Yang Wu,Fouad Yousif,Willie Yu,Steven G. Rozen,Vasilisa A. Rudneva,Suyash Shringarpure,Daniel J. Turner,Tian Xia,Gurnit Atwal,David K. Chang,Susanna L. Cooke,Bishoy Faltas,Syed Haider,Vera B. Kaiser,Rosa Karlic,Mamoru Kato,K Kübler,Adam A. Margolin,S. Martin,Serena Nik-Zainal,Christine P'ng,Colin A. Semple,Jaclyn Smith,Ren X. Sun,Kevin Thai,Derek W. Wright,Ke Yuan,Andrew V. Biankin,Levi A. Garraway,Sean M. Grimmond,David J. Adams,Pavana Anur,Shaolong Cao,Elizabeth L. Christie,Marek Cmero,Yupeng Cun,Kevin J. Dawson,Amit G. Deshwar,Nilgun Donmez,Ruben M. Drews,Moritz Gerstung,Gavin Ha,Kerstin Haase,Lara Jerman,Yuan Ji,Clemency Jolly,Juhee Lee,Henry Lee-Six,Salem Malikic,Thomas J. Mitchell,Quaid Morris,Layla Oesper,Martin Peifer,Myron Peto,Daniel Rosebrock,Yulia Rubanova,Adriana Salcedo,Subhajit Sengupta,Ruian Shi,Seung Jun Shin,Oliver Spiro,Shankar Vembu,Jeffrey A. Wintersinger,Tsun-Po Yang,Kaixian Yu,Hongtu Zhu,Paul T. Spellman,John N. Weinstein,Yiwen Chen,Masashi Fujita,Leng Han,Takanori Hasegawa,Mitsuhiro Komura,Jun Li,Shinichi Mizuno,Eigo Shimizu,Yumeng Wang,Yanxun Xu,Rui Yamaguchi,Fan Yang,Yang Yang,Christopher J. Yoon,Yuan Yuan,Han Liang,Malik Alawi,Ivan Borozan,Daniel Brewer,Colin Cooper,Nikita Desai,Adam Grundhoff,Murat Iskar,Xiaoping Su,Marc Zapatka,Peter Lichter,Kathryn Alsop,Timothy J. C. Bruxner,Angelika N. Christ,Stephen Cordner,Prue A. Cowin,Ronny Drapkin,Sian Fereday,Joshy George,Anne Hamilton,Oliver Holmes,Jillian Hung,Karin S. Kassahn,Stephen H. Kazakoff,Catherine J. Kennedy,Conrad Leonard,Linda Mileshkin,David Miller,Gisela Mir Arnau,Chris Mitchell,Felicity Newell,Katia Nones,Ann-Marie Patch,Michael C.J. Quinn,Darrin Taylor,Heather Thorne,Nadia Traficante,Ravikiran Vedururu,Nick Waddell,Paul Waring,Scott Wood,Qinying Xu,Anna deFazio,Matthew J. Anderson,Davide Antonello,Andrew Barbour,Claudio Bassi,Samantha Bersani,Ivana Cataldo,Lorraine A. Chantrill,Yoke-Eng Chiew,Angela Chou,Sara Cingarlini,Nicole Cloonan,Vincenzo Corbo,Maria Vittoria Davì,Fraser Duthie,Anthony J. Gill,Janet Graham,Ivon Harliwong,Nigel B. Jamieson,Amber L. Johns,James G. Kench,Luca Landoni,Rita T. Lawlor,Andrea Mafficini,Neil D. Merrett,Marco Miotto,Elizabeth A. Musgrove,Adnan Nagrial,Karin A. Oien,Marina Pajic,Mark Pinese,Alan J. Robertson,Ilse Rooman,Borislav Rusev,Jaswinder S. Samra,Maria Scardoni,Christopher J. Scarlett,Aldo Scarpa,Elisabetta Sereni,Katarzyna O. Sikora,Michele Simbolo,Morgan Taschuk,Christopher W. Toon,Caterina Vicentini,Jianmin Wu,Nikolajs Zeps,Andreas Behren,Hazel Burke,Jonathan Cebon,Rebecca A. Dagg,Ricardo De Paoli-Iseppi,Ken Dutton-Regester,Matthew A. Field,Anna Fitzgerald,Peter Hersey,Valerie Jakrot,Peter Johansson,Hojabr Kakavand,Richard F. Kefford,Loretta Lau,Georgina V. Long,Hilda A. Pickett,Antonia L. Pritchard,Gulietta M. Pupo,Robyn P. M. Saw,Sarah-Jane Schramm,Catherine A. Shang,Ping Shang,Andrew J. Spillane,Jonathan R. Stretch,Varsha Tembe,John F. Thompson,Ricardo E. Vilain,James S. Wilmott,Jean Y. Yang,Nicholas K. Hayward,Graham J. Mann,Richard A. Scolyer,John M. S. Bartlett,Prashant Bavi,Dianne Chadwick,Michelle Chan-Seng-Yue,Sean P. Cleary,Ashton A. Connor,Karolina Czajka,Robert E. Denroche,Neesha C. Dhani,Jenna Eagles,Steven Gallinger,Robert C. Grant,David W. Hedley,Michael A. Hollingsworth,Gun Ho Jang,Jeremy Johns,Sangeetha N Kalimuthu,Sheng-Ben Liang,Ilinca Lungu,Xuemei Luo,Faridah Mbabaali,Treasa McPherson,Jessica Miller,Malcolm J. Moore,Faiyaz Notta,Danielle Pasternack,Gloria M. Petersen,Michael H.A. Roehrl,Michelle Sam,Iris Selander,Stefano Serra,Sagedeh Shahabi,Sarah P. Thayer,Lee Timms,Gavin W. Wilson,Julie M. Wilson,Bradly G. Wouters,John Douglas Mcpherson,Timothy A. Beck,Vinayak Bhandari,Colin Collins,Neil Fleshner,Natalie S. Fox,Michael Fraser,Lawrence E. Heisler,Emilie Lalonde,Julie Livingstone,Alice Meng,Veronica Y. Sabelnykova,Yu-Jia Shiah,Theodorus van der Kwast,Robert G. Bristow,Shuai Ding,Daiming Fan,Lin Li,Yongzhan Nie,Xiao Xiao,Rui Xing,Shanlin Yang,Yingyan Yu,Yong Zhou,Rosamonde E. Banks,Guillaume Bourque,Paul Brennan,Louis Letourneau,Yasser Riazalhosseini,Ghislaine Scelo,Naveen S. Vasudev,Juris Viksna,Mark Lathrop,Jörg Tost,Sung-Min Ahn,Samuel Aparicio,Laurent Arnould,Miriam Ragle Aure,Shriram G. Bhosle,Ewan Birney,Åke Borg,Sandrine Boyault,Arie B. Brinkman,Jane E. Brock,Annegien Broeks,Anne Lise Børresen-Dale,Carlos Caldas,Suet-Feung Chin,Helen Davies,Christine Desmedt,Luc Dirix,Serge Dronov,Anna Ehinger,Jorunn E. Eyfjord,Aquila Fatima,John A. Foekens,P. A. Futreal,Øystein Garred,Dilip Giri,Dominik Glodzik,Dorthe Grabau,Holmfridur Hilmarsdottir,Gerrit K. J. Hooijer,Jocelyne Jacquemier,Se Jin Jang,Jon G. Jonasson,J Jonkers,Hyung-Yong Kim,Tari A. King,Stian Knappskog,Gu Kong,Savitri Krishnamurthy,Sunil R. Lakhani,Anita Langerød,Denis Larsimont,Hee Jin Lee,Jeong-Yeon Lee,Ming Ta Michael Lee,Ole Christian Lingjærde,Gaëtan MacGrogan,John W.M. Martens,Sarah O’Meara,Iris Pauporté,Sarah E Pinder,Xavier Pivot,Elena Provenzano,Colin A. Purdie,Manasa Ramakrishna,Kamna Ramakrishnan,Jorge S. Reis-Filho,Andrea L. Richardson,Markus Ringnér,Javier Bartolome Rodriguez,F. Germán Rodríguez-González,Gilles Romieu,Roberto Salgado,Torill Sauer,Rebecca Shepherd,Anieta M. Sieuwerts,Peter T. Simpson,Marcel Smid,Christos Sotiriou,Paul N. Span,Olafur A. Stefansson,Alasdair Stenhouse,Henk Stunnenberg,Fred C.G.J. Sweep,Benita Kiat Tee Tan,Gilles Thomas,Alastair M. Thompson,Stefania Tommasi,Isabelle Treilleux,Andrew Tutt,Naoto T. Ueno,Steven Van Laere,Gert Van den Eynden,Peter Vermeulen,Alain Viari,Anne Vincent-Salomon,Bernice H. Wong,Lucy R. Yates,Xueqing Zou,Carolien H.M. van Deurzen,Marc J. van de Vijver,Laura J. van't Veer,Ole Ammerpohl,Sietse M. Aukema,Anke K. Bergmann,Stephan H. Bernhart,Arndt Borkhardt,Christoph Borst,Birgit Burkhardt,Alexander Claviez,Maria Elisabeth Goebler,Andrea Haake,Siegfried Haas,Martin L. Hansmann,Jessica I. Hoell,Michael Hummel,Dennis Karsch,Wolfram Klapper,Michael Kneba,Markus Kreuz,Dieter Kube,Ralf Kueppers,Dido Lenze,Markus Loeffler,Cristina López,Luisa Mantovani-Loeffler,Peter Moeller,German Ott,Bernhard Radlwimmer,Julia Richter,Marius Rohde,Philip Rosenstiel,Andreas Rosenwald,Markus Schilhabel,Stefan Schreiber,Peter F. Stadler,Peter Staib,Stephan Stilgenbauer,Stephanie Sungalee,Monika Szczepanowski,Umut H. Toprak,Lorenz Truemper,Rabea Wagener,Thorsten Zenz,Volker Hovestadt,Christof von Kalle,Marcel Kool,Andrey Korshunov,Pablo Landgraf,Hans Lehrach,Paul A. Northcott,Stefan M. Pfister,Guido Reifenberger,Hans-Joerg Warnatz,Stephan Wolf,Marie-Laure Yaspo,Yassen Assenov,Clarissa Gerhäuser,Sarah Minner,Thorsten Schlomm,Ronald Simon,Guido Sauter,Holger Sueltmann,Nidhan K. Biswas,Arindam Maitra,Partha P. Majumder,Rajiv Sarin,Stefano Barbi,Giada Bonizzato,Cinzia Cantù,Angelo Paolo Dei Tos,Matteo Fassan,Sonia Grimaldi,Claudio Luchini,Giuseppe Malleo,Giovanni Marchegiani,Michele Milella,Salvatore Paiella,Antonio Pea,Paolo Pederzoli,Andrea Ruzzenente,Roberto Salvia,Nicola Sperandio,Yasuhito Arai,Natsuko Hama,Nobuyoshi Hiraoka,Fumie Hosoda,Hiromi Nakamura,Hidenori Ojima,Takuji Okusaka,Yasushi Totoki,Tomoko Urushidate,Masashi Fukayama,Shumpei Ishikawa,Hitoshi Katai,Hiroto Katoh,Daisuke Komura,Hirofumi Rokutan,Mihoko Saito-Adachi,Akihiro Suzuki,Hirokazu Taniguchi,Kenji Tatsuno,Tetsuo Ushiku,Shinichi Yachida,Shogo Yamamoto,Hiroshi Aikata,Koji Arihiro,Shunichi Ariizumi,Kazuaki Chayama,Mayuko Furuta,Kunihito Gotoh,Shinya Hayami,Satoshi Hirano,Yoshiiku Kawakami,Kazuhiro Maejima,Toru Nakamura,Kaoru Nakano,Hideki Ohdan,Aya Sasaki-Oku,Hiroko Tanaka,Masaki Ueno,Masakazu Yamamoto,Hiroki Yamaue,Su Pin Choo,Ioana Cutcutache,Narong Khuntikeo,Choon Kiat Ong,Chawalit Pairojkul,Irinel Popescu,Keun Soo Ahn,Marta Aymerich,Armando López-Guillermo,Carlos López-Otín,Xose S. Puente,Elias Campo,Fernanda Amary,Daniel Baumhoer,Sam Behjati,Bodil Bjerkehagen,Ola Myklebost,Nischalan Pillay,P. S. Tarpey,Roberto Tirabosco,Olga Zaikova,Adrienne M. Flanagan,Jacqueline Boultwood,David T. Bowen,Mario Cazzola,Anthony R. Green,Eva Hellström-Lindberg,Luca Malcovati,Jyoti Nangalia,Elli Papaemmanuil,Paresh Vyas,Yeng Ang,Hugh Barr,Duncan Beardsmore,Matthew D. Eldridge,James A. Gossage,Nicola Grehan,George B. Hanna,Stephen J. Hayes,Ted R. Hupp,David Khoo,Jesper Lagergren,Laurence Lovat,Shona MacRae,Maria O'Donovan,J. Robert O’Neill,Simon L. Parsons,Shaun R. Preston,Sonia Puig,Tom Roques,Grant Sanders,Sharmila Sothi,Simon Tavaré,Olga Tucker,Richard C. Turkington,Timothy J. Underwood,Ian Welch,Rebecca C. Fitzgerald,Daniel M. Berney,Johann S. De Bono,Declan Cahill,Niedzica Camacho,Nening Dennis,Tim Dudderidge,S. Edwards,Cyril Fisher,Christopher S. Foster,Mohammed J. R. Ghori,Pelvender Gill,Vincent J. Gnanapragasam,Gunes Gundem,Freddie C. Hamdy,Steve Hawkins,Steven Hazell,William J. Howat,William B. Isaacs,Katalin Karaszi,Jonathan D. Kay,Vincent Khoo,Z Kote-Jarai,Barbara Kremeyer,Pardeep Kumar,Adam Lambert,D. Leongamornlert,Naomi Livni,Yong-Jie Lu,Hayley J. Luxton,Luke Marsden,Charles E. Massie,Lucy Matthews,Erik Mayer,Ultan McDermott,Sue Merson,David E. Neal,Anthony C. H. Ng,David Nicol,Chris Ogden,Edward Rowe,Nimish Shah,Sarah Thomas,Alan Thompson,Clare Verrill,Tapio Visakorpi,Anne Y. Warren,Hayley C. Whitaker,Hongwei Zhang,Nicholas van As,Rosalind A. Eeles,Adam Abeshouse,Nishant Agrawal,Rehan Akbani,Hikmat Al Ahmadie,Monique Albert,Kenneth Aldape,Adrian Ally,Elizabeth L. Appelbaum,Joshua Armenia,Sylvia L. Asa,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Jill S. Barnholtz-Sloan,Oliver F. Bathe,Stephen B. Baylin,Christopher C. Benz,Andrew Berchuck,Mario Berrios,Darell D. Bigner,Michael Birrer,Tom Bodenheimer,Lori Boice,Moiz S. Bootwalla,Marcus Bosenberg,Reanne Bowlby,Jeff Boyd,Russell R. Broaddus,Malcolm V. Brock,Denise Brooks,Susan Bullman,Samantha J. Caesar-Johnson,Thomas E. Carey,Rebecca Carlsen,Robert J. Cerfolio,Vishal S. Chandan,Hsiao-Wei Chen,Andrew D. Cherniack,Jeremy Chien,Juok Cho,Eric Chuah,Carrie Cibulskis,Leslie Cope,Matthew G. Cordes,Erin Curley,Bogdan Czerniak,Ludmila Danilova,Ian J. Davis,Timothy Defreitas,John A. Demchok,Noreen Dhalla,Rajiv Dhir,Harshavardhan Doddapaneni,Adel K. El-Naggar,Ina Felau,Martin L. Ferguson,Gaetano Finocchiaro,Kwun M. Fong,Scott Frazer,William A. Friedman,Catrina C. Fronick,Lucinda Fulton,Stacey Gabriel,Jianjiong Gao,Nils Gehlenborg,Jeffrey E. Gershenwald,Ronald Ghossein,Nasra H. Giama,Richard A. Gibbs,Carmen Gomez,Ramaswamy Govindan,D. Neil Hayes,Apurva M. Hegde,David I. Heiman,Zachary J. Heins,Austin J. Hepperla,Andrea Holbrook,Robert A. Holt,Alan P. Hoyle,Ralph H. Hruban,Jianhong Hu,Mei Huang,David G. Huntsman,Jason T. Huse,Christine A. Iacobuzio Donahue,Michael Ittmann,Joy Jayaseelan,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Hartmut Juhl,Koo Jeong Kang,Beth Y. Karlan,Katayoon Kasaian,Electron Kebebew,Hark Kyun Kim,Viktoriya Korchina,Ritika Kundra,Phillip H. Lai,Eric S. Lander,Xuan Le,Darlene Lee,Douglas A. Levine,Lora Lewis,Tim Ley,Haiyan Irene Li,Pei Lin,W. M. Linehan,Fei-Fei Liu,Yiling Lu,Lisa Lype,Yussanne Ma,Dennis T. Maglinte,Elaine R. Mardis,Jeffrey R. Marks,Marco A. Marra,Thomas Matthew,Michael Mayo,Karen K. Smith McCune,Sam Meier,Shaowu Meng,Piotr A. Mieczkowski,Tom Mikkelsen,Christopher A. Miller,Gordon B. Mills,Richard A. Moore,Carl Morrison,Lisle E. Mose,Catherine D. Moser,Andrew J. Mungall,Karen Mungall,David G. Mutch,Donna Muzny,Jerome Myers,Yulia Newton,Michael S. Noble,Peter H. O'Donnell,Brian P. O'Neill,Angelica Ochoa,Joong-Won Park,Joel S. Parker,Harvey I. Pass,Alessandro Pastore,Nathan A. Pennell,Charles M. Perou,Nicholas J. Petrelli,Olga Potapova,Janet S. Rader,Suresh S. Ramalingam,W. Kimryn Rathmell,Victor E. Reuter,Sheila Reynolds,Matthew D. Ringel,Jeffrey Roach,Lewis R. Roberts,A. Gordon Robertson,Sara Sadeghi,Charles Saller,Francisco Sanchez-Vega,Dirk Schadendorf,Jacqueline E. Schein,Heather K. Schmidt,Nikolaus Schultz,Raja R. Seethala,Yasin Senbabaoglu,Troy Shelton,Yan Shi,Juliann Shih,Ilya Shmulevich,Craig D. Shriver,Sabina Signoretti,Janae V. Simons,Samuel Singer,Payal Sipahimalani,Tara Skelly,Karen Smith McCune,Nicholas D. Socci,Matthew G. Soloway,Anil K. Sood,Angela Tam,Donghui Tan,Roy Tarnuzzer,Nina Thiessen,R. Houston Thompson,Leigh B. Thorne,M. Tsao,Christopher B. Umbricht,David Van Den Berg,Erwin G. Van Meir,Umadevi Veluvolu,Douglas Voet,Linghua Wang,Paul Weinberger,Daniel J. Weisenberger,Dennis A. Wigle,Matthew D. Wilkerson,Richard K. Wilson,Boris Winterhoff,Maciej Wiznerowicz,Tina Wong,Wing Hing Wong,Liu Xi,Christina Yau,Hailei Zhang,Hongxin Zhang,Jiashan Zhang +1332 more
TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.
Journal ArticleDOI
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Katherine A Hoadley,Christina Yau,Christina Yau,Toshinori Hinoue,Denise M. Wolf,Alexander J. Lazar,Esther Drill,Ronglai Shen,Alison M. Taylor,Alison M. Taylor,Andrew D. Cherniack,Andrew D. Cherniack,Vesteinn Thorsson,Rehan Akbani,Reanne Bowlby,Christopher K. Wong,Maciej Wiznerowicz,Maciej Wiznerowicz,Francisco Sanchez-Vega,A. Gordon Robertson,Barbara G. Schneider,Michael S. Lawrence,Michael S. Lawrence,Houtan Noushmehr,Houtan Noushmehr,Tathiane M. Malta,Tathiane M. Malta,Samantha J. Caesar-Johnson,John A. Demchok,Ina Felau,Melpomeni Kasapi,Martin L. Ferguson,Carolyn M. Hutter,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Jiashan Zhang,Sudha Chudamani,Jia Liu,Laxmi Lolla,Rashi Naresh,Todd Pihl,Qiang Sun,Yunhu Wan,Ye Wu,Juok Cho,Timothy Defreitas,Scott Frazer,Nils Gehlenborg,Gad Getz,David I. Heiman,Jaegil Kim,Pei Lin,Sam Meier,Michael S. Noble,Gordon Saksena,Doug Voet,Hailei Zhang,Brady Bernard,Nyasha Chambwe,Varsha Dhankani,Theo A. Knijnenburg,Roger Kramer,Kalle Leinonen,Yuexin Liu,Michael W. Miller,Sheila Reynolds,Ilya Shmulevich,Wei Zhang,Bradley M. Broom,Apurva M. Hegde,Zhenlin Ju,Rupa S. Kanchi,Anil Korkut,Jun Li,Han Liang,Shiyun Ling,Wen-Bin Liu,Yiling Lu,Gordon B. Mills,Kwok Shing Ng,Arvind Rao,Michael T. Ryan,Jing Wang,John N. Weinstein,Jiexin Zhang,Adam Abeshouse,Joshua Armenia,Debyani Chakravarty,Walid K. Chatila,Ino de Bruijn,Jianjiong Gao,Benjamin Gross,Zachary J. Heins,Ritika Kundra,Konnor La,Marc Ladanyi,Augustin Luna,Moriah G. Nissan,Angelica Ochoa,Sarah Phillips,Ed Reznik,Chris Sander,Nikolaus Schultz,Robert L. Sheridan,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Jioajiao Wang,Hongxin Zhang,Pavana Anur,Myron Peto,Paul T. Spellman,Christopher C. Benz,Joshua M. Stuart,D. Neil Hayes,Joel S. Parker,Matthew D. Wilkerson,Adrian Ally,Miruna Balasundaram,Denise Brooks,Rebecca Carlsen,Eric Chuah,Noreen Dhalla,Robert A. Holt,Steven J.M. Jones,Katayoon Kasaian,Darlene Lee,Yussanne Ma,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Karen Mungall,Sara Sadeghi,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Kane Tse,Tina Wong,Ashton C. Berger,Rameen Beroukhim,Carrie Cibulskis,Stacey Gabriel,Galen F. Gao,Gavin Ha,Matthew Meyerson,Steven E. Schumacher,Juliann Shih,Melanie H. Kucherlapati,Raju Kucherlapati,Stephen B. Baylin,Leslie Cope,Ludmila Danilova,Moiz S. Bootwalla,Phillip H. Lai,Dennis T. Maglinte,David Van Den Berg,Daniel J. Weisenberger,J. Todd Auman,Saianand Balu,Tom Bodenheimer,Cheng Fan,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Amy H. Perou,Charles M. Perou,Jeffrey Roach,Yan Shi,Janae V. Simons,Tara Skelly,Matthew G. Soloway,Donghui Tan,Umadevi Veluvolu,Huihui Fan,Peter W. Laird,Hui Shen,Wanding Zhou,Michelle Bellair,Kyle Chang,Kyle R. Covington,Chad J. Creighton,Huyen Dinh,Harshavardhan Doddapaneni,Lawrence A. Donehower,Jennifer Drummond,Richard A. Gibbs,Robert Glenn,Walker Hale,Yi Han,Jianhong Hu,Viktoriya Korchina,Sandra J. Lee,Lora Lewis,W. G. Li,Xiuping Liu,Margaret Morgan,Donna Morton,Donna M. Muzny,Jireh Santibanez,Margi Sheth,Eve Shinbrot,Linghua Wang,Min Wang,David A. Wheeler,Liu Xi,Fengmei Zhao,Julian M. Hess,Elizabeth L. Appelbaum,Matthew A. Bailey,Matthew G. Cordes,Li Ding,Catrina Fronick,Lucinda Fulton,Robert S. Fulton,Cyriac Kandoth,Elaine R. Mardis,Michael D. McLellan,Christopher A. Miller,Heather Schmidt,Rick K. Wilson,Daniel Crain,Erin Curley,Johanna Gardner,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Candace Shelton,Troy Shelton,Mark E. Sherman,Eric M. Thompson,Peggy Yena,Jay Bowen,Julie M. Gastier-Foster,Mark Gerken,Kristen M. Leraas,Tara M. Lichtenberg,Nilsa C. Ramirez,Lisa Wise,Erik Zmuda,Niall M. Corcoran,Tony Costello,Christopher M. Hovens,André Lopes Carvalho,Ana Carolina de Carvalho,José Humberto Tavares Guerreiro Fregnani,Adhemar Longatto-Filho,Rui Manuel Reis,Cristovam Scapulatempo-Neto,Henrique César Santejo Silveira,Daniel Onofre Vidal,Andrew Burnette,Jennifer M. Eschbacher,Beth Hermes,Ardene Noss,Rosy Singh,Matthew L. Anderson,Patricia Castro,Michael Ittmann,David G. Huntsman,Bernard Kohl,Xuan Le,Richard Thorp,Chris Andry,Elizabeth R. Duffy,Vladimir Lyadov,Oxana Paklina,Galiya Setdikova,Alexey Shabunin,Mikhail Tavobilov,Christopher M. McPherson,Ronald E. Warnick,Ross S. Berkowitz,Daniel W. Cramer,Colleen M. Feltmate,Neil S. Horowitz,Adam S. Kibel,Michael G. Muto,Chandrajit P. Raut,Andrei Malykh,Jill S. Barnholtz-Sloan,Wendi Barrett,Karen Devine,Jordonna Fulop,Quinn T. Ostrom,Kristen Shimmel,Yingli Wolinsky,Andrew E. Sloan,Agostino Maria De Rose,Felice Giuliante,Marc T. Goodman,Beth Y. Karlan,Curt H. Hagedorn,John Eckman,Jodi Harr,Jerome Myers,Kelinda Tucker,Leigh Anne Zach,Brenda Deyarmin,Hai Hu,Leonid Kvecher,Caroline Larson,Richard J. Mural,Stella Somiari,Ales Vicha,Tomáš Zelinka,Joseph J. Bennett,Mary Iacocca,Brenda Rabeno,Patricia Swanson,Mathieu Latour,Louis Lacombe,Bernard Têtu,Alain Bergeron,Mary McGraw,Susan M. Staugaitis,John Chabot,Hanina Hibshoosh,Antonia R. Sepulveda,Tao Su,Timothy C. Wang,Olga Potapova,Olga Voronina,Laurence Desjardins,Odette Mariani,Sergio Roman-Roman,Xavier Sastre,Marc-Henri Stern,Feixiong Cheng,Sabina Signoretti,Andrew Berchuck,Darell D. Bigner,Eric S. Lipp,Jeffrey R. Marks,Shannon J. McCall,Roger E. McLendon,Angeles Alvarez Secord,Alexis Sharp,Madhusmita Behera,Daniel J. Brat,Amy Y. Chen,Keith A. Delman,Seth D. Force,Fadlo R. Khuri,Kelly R. Magliocca,Shishir K. Maithel,Jeffrey J. Olson,Taofeek K. Owonikoko,Alan Pickens,Suresh S. Ramalingam,Dong M. Shin,Gabriel Sica,Erwin G. Van Meir,Hongzheng Zhang,Wil Eijckenboom,Ad J. M. Gillis,Esther Korpershoek,Leendert H. J. Looijenga,Wolter Oosterhuis,Hans Stoop,Kim E.M. van Kessel,Ellen C. Zwarthoff,Chiara Calatozzolo,Lucia Cuppini,Stefania Cuzzubbo,Francesco DiMeco,Gaetano Finocchiaro,Luca Mattei,Alessandro Perin,Bianca Pollo,Chu Chen,John Houck,Pawadee Lohavanichbutr,Arndt Hartmann,Christine Stoehr,Robert Stoehr,Helge Taubert,Sven Wach,Bernd Wullich,Witold Kycler,Dawid Murawa,Ki Chung,W. Jeffrey Edenfield,Julie S. Martin,Eric Baudin,Glenn J. Bubley,Raphael Bueno,Assunta De Rienzo,William G. Richards,Steven N. Kalkanis,Tom Mikkelsen,Lisa Scarpace,Nicolas Girard,Marta Aymerich,Elias Campo,Eva Giné,Armando López Guillermo,Nguyen Van Bang,Phan Thi Hanh,Bui Duc Phu,Yufang Tang,Howard Colman,Kimberley Evason,Peter Dottino,John A. Martignetti,Hani Gabra,Hartmut Juhl,Teniola Akeredolu,Serghei Stepa,Dave S.B. Hoon,Keunsoo Ahn,Koo Jeong Kang,Felix Beuschlein,Anne Breggia,Michael J. Birrer,Debra A. Bell,Mitesh J. Borad,Alan H. Bryce,Erik P. Castle,Vishal S. Chandan,John C. Cheville,John A. Copland,Michael B. Farnell,Thomas J. Flotte,Nasra H. Giama,Thai H. Ho,Michael L. Kendrick,Jean Pierre A. Kocher,Karla Kopp,Catherine D. Moser,David M. Nagorney,Daniel R. O'Brien,Brian P. O'Neill,Tushar Patel,Gloria M. Petersen,Florencia G. Que,Michael Rivera,Lewis R. Roberts,Robert C. Smallridge,Thomas C. Smyrk,Melissa L. Stanton,R. Houston Thompson,Michael Torbenson,Ju Dong Yang,Lizhi Zhang,Fadi Brimo,Jaffer A. Ajani,Ana Maria Angulo Gonzalez,Carmen Behrens,olanta Bondaruk,Russell Broaddus,Bogdan Czerniak,Bita Esmaeli,Junya Fujimoto,Jeffrey E. Gershenwald,Charles C. Guo,Christopher J. Logothetis,Funda Meric-Bernstam,Cesar A. Moran,Lois M. Ramondetta,David C. Rice,Anil K. Sood,Pheroze Tamboli,Timothy C. Thompson,Patricia Troncoso,Anne Tsao,Ignacio I. Wistuba,Candace Carter,Lauren E. Haydu,Peter Hersey,Valerie Jakrot,Hojabr Kakavand,Richard F. Kefford,Kenneth K. Lee,Georgina V. Long,Graham J. Mann,Michael A. Quinn,Robyn P. M. Saw,Richard A. Scolyer,Kerwin F. Shannon,Andrew J. Spillane,Jonathan R. Stretch,Maria Synott,John F. Thompson,James S. Wilmott,Hikmat Al-Ahmadie,Timothy A. Chan,Ronald Ghossein,Anuradha Gopalan,Douglas A. Levine,Victor E. Reuter,Samuel Singer,Bhuvanesh Singh,Nguyen Viet Tien,Thomas Broudy,Cyrus Mirsaidi,Praveen Nair,Paul Drwiega,Judy Miller,Jennifer S. Smith,Howard Zaren,Joong-Won Park,Nguyen Phi Hung,Electron Kebebew,W. Marston Linehan,Adam R. Metwalli,Karel Pacak,Peter A. Pinto,Mark Schiffman,Laura S. Schmidt,Cathy D. Vocke,Nicolas Wentzensen,Robert Worrell,Hannah P. Yang,Marc Moncrieff,Chandra Goparaju,Jonathan Melamed,Harvey I. Pass,Natalia Botnariuc,Irina Caraman,Mircea Cernat,Inga Chemencedji,Adrian Clipca,Serghei Doruc,Ghenadie Gorincioi,Sergiu Mura,Maria Pirtac,Irina Stancul,Diana Tcaciuc,Monique Albert,Iakovina Alexopoulou,Angel Arnaout,John Bartlett,Jay Engel,Sebastien Gilbert,Jeremy Parfitt,Harman Sekhon,George Thomas,Doris M. Rassl,Robert C. Rintoul,Carlo Bifulco,Raina Tamakawa,Walter J. Urba,Nicholas K. Hayward,Henri J L M Timmers,Anna Antenucci,Francesco Facciolo,Gian Luca Grazi,Mirella Marino,Roberta Merola,Ronald R. de Krijger,Anne Paule Gimenez-Roqueplo,Alain Piché,Simone Chevalier,Ginette McKercher,Kıvanç Birsoy,Gene H. Barnett,Cathy Brewer,Carol Farver,Theresa Naska,Nathan A. Pennell,Daniel P. Raymond,Cathy Schilero,Kathy Smolenski,Felicia Williams,Carl Morrison,Jeffrey A. Borgia,Michael J. Liptay,Mark Pool,Christopher W. Seder,Kerstin Junker,Larsson Omberg,Mikhail Dinkin,George Manikhas,Domenico Alvaro,Maria Consiglia Bragazzi,Vincenzo Cardinale,Guido Carpino,Eugenio Gaudio,David Chesla,Sandra Cottingham,Michael Dubina,Fedor Moiseenko,Renumathy Dhanasekaran,Karl-Friedrich Becker,Klaus-Peter Janssen,Julia Slotta-Huspenina,Mohamed H. Abdel-Rahman,Dina Aziz,Sue E. Bell,Colleen M. Cebulla,Amy Davis,Rebecca Duell,J. Bradley Elder,Joe Hilty,Bahavna Kumar,James C. Lang,Norman L. Lehman,Randy Mandt,Phuong Nguyen,Robert Pilarski,Karan Rai,Lynn Schoenfield,Kelly Senecal,Paul Wakely,Paul Hansen,Ronald Lechan,James Powers,Arthur S. Tischler,William E. Grizzle,Katherine C. Sexton,Alison Kastl,Joel M. Henderson,Sima P. Porten,Jens Waldmann,Martin Fassnacht,Sylvia L. Asa,Dirk Schadendorf,Marta Couce,Markus Graefen,Hartwig Huland,Guido Sauter,Thorsten Schlomm,Ronald Simon,Pierre Tennstedt,Oluwole Olabode,Mark Nelson,Oliver F. Bathe,Peter R. Carroll,June M. Chan,Philip J. DiSaia,Pat Glenn,Robin Kate Kelley,Charles N. Landen,Joanna J. Phillips,Michael D. Prados,Jeffry P. Simko,Karen Smith-McCune,Scott R. VandenBerg,Kevin K. Roggin,Ashley Fehrenbach,Ady Kendler,Suzanne Sifri,Ruth Steele,Antonio Jimeno,Francis Carey,Ian Forgie,Massimo Mannelli,Michael E. Carney,Brenda Y. Hernandez,Benito Campos,Christel Herold-Mende,Christin Jungk,Andreas Unterberg,Andreas von Deimling,Aaron D. Bossler,Joseph Galbraith,Laura Jacobus,Michael Knudson,Tina Knutson,Deqin Ma,Mohammed M. Milhem,Rita Sigmund,Andrew K. Godwin,Rashna Madan,Howard G. Rosenthal,Clement Adebamowo,Sally N. Adebamowo,Alex Boussioutas,David G. Beer,Thomas J. Giordano,Anne Marie Mes-Masson,Fred Saad,Thèrése Bocklage,Lisa M. Landrum,Robert S. Mannel,Kathleen N. Moore,Katherine M. Moxley,Russel Postier,Joan L. Walker,Rosemary E. Zuna,Michael Feldman,Federico Valdivieso,Rajiv Dhir,James D. Luketich,Edna M. Mora Pinero,Mario Quintero-Aguilo,Carlos Gilberto Carlotti,Jose Sebastião Dos Santos,Rafael Kemp,Ajith Sankarankuty,Daniela Pretti da Cunha Tirapelli,James W.F. Catto,Kathy Agnew,Elizabeth M. Swisher,Jenette Creaney,Bruce W. S. Robinson,Carl Simon Shelley,Eryn M. Godwin,Sara Kendall,Cassaundra Shipman,Carol R. Bradford,Thomas E. Carey,Andrea Haddad,Jeffey Moyer,Lisa A. Peterson,Mark E. Prince,Laura S. Rozek,Gregory T. Wolf,Rayleen V. Bowman,Kwun M. Fong,Ian A. Yang,Robert Korst,W. Kimryn Rathmell,J. Leigh Fantacone-Campbell,Jeffrey A. Hooke,Albert J. Kovatich,Craig D. Shriver,John F. DiPersio,Bettina F. Drake,Ramaswamy Govindan,Sharon Heath,Timothy J. Ley,Brian A. Van Tine,Peter Westervelt,Mark A. Rubin,Jung Il Lee,Natália D. Aredes,Armaz Mariamidze,Christopher C. Benz +738 more
TL;DR: Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, Pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which may inform strategies for future therapeutic development.
Journal ArticleDOI
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.
Hira Rizvi,Francisco Sanchez-Vega,Konnor La,Walid K. Chatila,Philip Jonsson,Darragh Halpenny,Andrew J. Plodkowski,Niamh Long,Jennifer L. Sauter,Natasha Rekhtman,Travis J. Hollmann,Kurt A. Schalper,Justin F. Gainor,Ronglai Shen,Ai Ni,Kathryn C. Arbour,Taha Merghoub,Jedd D. Wolchok,Alexandra Snyder,Jamie E. Chaft,Mark G. Kris,Charles M. Rudin,Nicholas D. Socci,Michael F. Berger,Barry S. Taylor,Ahmet Zehir,David B. Solit,Maria E. Arcila,Marc Ladanyi,Gregory J. Riely,Nikolaus Schultz,Matthew D. Hellmann +31 more
TL;DR: Targeted NGS accurately estimates tumor mutation burden and elevated TMB further improved likelihood of benefit to ICIs, and the incorporation of both TMB and PD-L1 expression into multivariable predictive models should result in greater predictive power.
Journal ArticleDOI
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
Matthew D. Hellmann,Tavi Nathanson,Hira Rizvi,Benjamin C. Creelan,Francisco Sanchez-Vega,Arun Ahuja,Ai Ni,Jacqueline Buros Novik,Levi Mangarin,Mohsen Abu-Akeel,Cailian Liu,Jennifer L. Sauter,Natasha Rekhtman,Eliza Chang,Margaret K. Callahan,Margaret K. Callahan,Jamie E. Chaft,Jamie E. Chaft,Martin H. Voss,Martin H. Voss,Megan Tenet,Xuemei Li,Kelly L. Covello,Andrea Renninger,Patrik Vitazka,William J. Geese,Hossein Borghaei,Charles M. Rudin,Charles M. Rudin,Scott J. Antonia,Charles Swanton,Charles Swanton,Jeff Hammerbacher,Jeff Hammerbacher,Taha Merghoub,Nicholas McGranahan,Alexandra Snyder,Jedd D. Wolchok +37 more
TL;DR: The low response rate in TMB low NSCLCs demonstrates that combination immunotherapy does not overcome the negative predictive impact of low TMB, and TMB should be incorporated in future trials examining PD-(L)1 with CTLA-4 blockade in NSCLC.
Journal ArticleDOI
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Adam Abeshouse,Clement Adebamowo,Sally N. Adebamowo,Rehan Akbani,Teniola Akeredolu,Adrian Ally,Matthew L. Anderson,Pavana Anur,Elizabeth L. Appelbaum,Joshua Armenia,J. Todd Auman,Matthew A. Bailey,Laurence H. Baker,Miruna Balasundaram,Saianand Balu,Floris P. Barthel,John Bartlett,Stephen B. Baylin,Madhusmita Behera,Dmitry Belyaev,Joesph Bennett,Christopher C. Benz,Rameen Beroukhim,Michael J. Birrer,Therese Bocklage,Tom Bodenheimer,Lori Boice,Moiz S. Bootwalla,Jay Bowen,Reanne Bowlby,Jeff Boyd,Andrew S. Brohl,Denise Brooks,Lauren Averett Byers,Rebecca Carlsen,Patricia Castro,Hsiao-Wei Chen,Andrew D. Cherniack,Frédéric Chibon,Lynda Chin,Juok Cho,Eric Chuah,Sudha Chudamani,Carrie Cibulskis,Lee Cooper,Leslie Cope,Matthew G. Cordes,Daniel Crain,Erin Curley,Ludmila Danilova,Fanny Dao,Ian J. Davis,Lara E. Davis,Timothy Defreitas,Keith A. Delman,John A. Demchok,George D. Demetri,Elizabeth G. Demicco,Noreen Dhalla,Lixia Diao,Li Ding,Phil DiSaia,Peter Dottino,Leona A. Doyle,Esther Drill,Michael Dubina,Jennifer M. Eschbacher,Konstantin V. Fedosenko,Ina Felau,Martin L. Ferguson,Scott Frazer,Catrina Fronick,Victoria Fulidou,Lucinda Fulton,Robert S. Fulton,Stacey Gabriel,Jianjiong Gao,Qingsong Gao,Johanna Gardner,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Gad Getz,Andrew K. Godwin,Eryn M. Godwin,Elena Gordienko,Juneko E. Grilley-Olson,David A. Gutman,David H. Gutmann,D. Neil Hayes,Apurva M. Hegde,David I. Heiman,Zachary J. Heins,Carmen Helsel,Austin J. Hepperla,Kelly Higgins,Katherine A. Hoadley,Shital Hobensack,Robert A. Holt,Dave B. Hoon,Jason L. Hornick,Alan P. Hoyle,Xin Hu,Mei Huang,Carolyn M. Hutter,Mary Iacocca,Davis R. Ingram,Michael Ittmann,Lisa Iype,Stuart R. Jefferys,Kevin B. Jones,Corbin D. Jones,Steven J.M. Jones,Tamara Kalir,Beth Y. Karlan,Apollon Karseladze,Katayoon Kasaian,Jaegil Kim,Ritika Kundra,Hanluen Kuo,Marc Ladanyi,Phillip H. Lai,Peter W. Laird,Erik G. Larsson,Michael S. Lawrence,Alexander J. Lazar,Sanghoon Lee,Darlene Lee,Kjong-Van Lehmann,Kristen M. Leraas,Jenny Lester,Douglas A. Levine,Irene Li,Tara M. Lichtenberg,Pei Lin,Jia Liu,Wen-Bin Liu,Eric Minwei Liu,Laxmi Lolla,Yiling Lu,Yussanne Ma,Rashna Madan,Dennis T. Maglinte,Anthony M. Magliocco,Robert G. Maki,David Mallery,Georgy Manikhas,Elaine R. Mardis,Armaz Mariamidze,Marco A. Marra,John A. Martignetti,Cathleen Martinez,Michael Mayo,Michael D. McLellan,Sam Meier,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,Christopher A. Miller,Gordon B. Mills,Richard A. Moore,Scott Morris,Lisle E. Mose,Evgeny Mozgovoy,Andrew J. Mungall,Karen Mungall,Michael Nalisnik,Rashi Naresh,Yulia Newton,Michael S. Noble,Janet E. Novak,Angelica Ochoa,Narciso Olvera,Taofeek K. Owonikoko,Oxana Paklina,Jeremy Parfitt,Joel S. Parker,Alessandro Pastore,Joseph Paulauskis,Robert Penny,Elena Pereira,Charles M. Perou,Amy H. Perou,Todd Pihl,Raphael E. Pollock,Olga Potapova,Amie Radenbaugh,Suresh S. Ramalingam,Nilsa C. Ramirez,W. Kimryn Rathmell,Chandrajit P. Raut,Richard F. Riedel,Colleen Reilly,Sheila Reynolds,Jeffrey Roach,A. Gordon Robertson,Jason Roszik,Brian P. Rubin,Sara Sadeghi,Gordon Saksena,Andrew Salner,Francisco Sanchez-Vega,Chris Sander,Jacqueline E. Schein,Heather Schmidt,Nikolaus Schultz,Steven E. Schumacher,Harman Sekhon,Yasin Senbabaoglu,Galiya Setdikova,Candace Shelton,Troy Shelton,Ronglai Shen,Yan Shi,Juliann Shih,Ilya Shmulevich,Gabriel Sica,Janae V. Simons,Samuel Singer,Payal Sipahimalani,Tara Skelly,Nicholas D. Socci,Heidi J. Sofia,Matthew G. Soloway,Paul T. Spellman,Qiang Sun,Patricia Swanson,Angela Tam,Donghui Tan,Roy Tarnuzzer,Nina Thiessen,Eric M. Thompson,Leigh B. Thorne,Pan Tong,Keila E. Torres,Matt van de Rijn,David Van Den Berg,Brian A. Van Tine,Umadevi Veluvolu,Roel G.W. Verhaak,Doug Voet,Olga Voronina,Yunhu Wan,Zhining Wang,Jing Wang,John N. Weinstein,Daniel J. Weisenberger,Matthew D. Wilkerson,Richard K. Wilson,Lisa Wise,Tina Wong,Wing Hing Wong,John Wrangle,Ye Wu,Matthew A. Wyczalkowski,Liming Yang,Christina Yau,Venkata Yellapantula,Jean C. Zenklusen,Jiashan Zhang,Hailei Zhang,Hongxin Zhang,Erik Zmuda +262 more
TL;DR: This large-scale analysis of 206 adult soft tissue sarcomas reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining Sarcoma therapy and relationships to other cancer types.