F
Frank Caruso
Researcher at University of Melbourne
Publications - 676
Citations - 68648
Frank Caruso is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polyelectrolyte & Nanoparticle. The author has an hindex of 131, co-authored 641 publications receiving 61748 citations. Previous affiliations of Frank Caruso include Commonwealth Scientific and Industrial Research Organisation & University of Rome Tor Vergata.
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Journal ArticleDOI
Uptake and Intracellular Fate of Disulfide-Bonded Polymer Hydrogel Capsules for Doxorubicin Delivery to Colorectal Cancer Cells
Yan Yan,Angus P. R. Johnston,Sarah J. Dodds,Marloes M. J. Kamphuis,Charles Ferguson,Robert G. Parton,Edouard C. Nice,Joan K. Heath,Frank Caruso +8 more
TL;DR: The DOX-loaded PMA(SH) capsules demonstrate a 5000-fold enhanced cytotoxicity in cell viability studies compared to free DOX and are demonstrated to be redox-responsive for the delivery of doxorubicin to colon cancer cells.
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Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules
Marloes M. J. Kamphuis,Angus P. R. Johnston,Georgina K. Such,Henk H. Dam,Richard A. Evans,Andrew M. Scott,Edouard C. Nice,Joan K. Heath,Frank Caruso +8 more
TL;DR: It is demonstrated that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population.
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Nanotubes Prepared by Templating Sacrificial Nickel Nanorods
TL;DR: In this article, a layer-by-layer (LbL) deposition of polyelectrolytes and/or a charged inorganic molecular precursor onto nickel nanorods, followed by removal of the core by dissolution.
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Influence of size, surface, cell line, and kinetic properties on the specific binding of A33 antigen-targeted multilayered particles and capsules to colorectal cancer cells
Christina Cortez,Eva Tomaskovic-Crook,Angus P. R. Johnston,Andrew M. Scott,Edouard C. Nice,Joan K. Heath,Frank Caruso +6 more
TL;DR: Flow cytometry experiments showed the cell binding specificity of huA33 mAb-coated particles to be size-dependent, with the optimal size for enhanced selectivity at approximately 500 nm, and the specific binding was improved by increasing the dosage of particles incubated with the cells.
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Engineering particles for therapeutic delivery: prospects and challenges.
TL;DR: Recent progress in particle-based therapeutic delivery is summarized and important concepts in particle design and biological barriers for developing the next generation of particles are discussed.