Frauke Seehusen

TL;DR: DL represents a biphasic disease process consisting of an initial direct virus-mediated process and immune-mediated plaque progression, and an altered balance between matrix metalloproteinases and their inhibitors seems to play a pivotal role for the pathogenesis of DL.

TL;DR: The prevalence of HEV infection in Central European liver transplant recipients is low; however, chronic hepatitis E may occur and needs to be considered in the differential diagnosis of graft hepatitis.

TL;DR: In vivo and in vitro investigations provided new insights into its pathogenesis with special emphasis on axon-myelin-glia interaction, potential endogenous mechanisms of regeneration, and astroglial plasticity, and the detection of early axonal damage suggests that demyelination is at least in part a secondary event in CDV-DL, thus challenging the dogma of CDV as a purely primary demYelinating disease.

TL;DR: The observed findings indicate that axonal damage occurs early in DL; can be detected before myelin loss; and represents a pivotal feature in advanced lesions.

TL;DR: The present findings indicate a change in cell tropism of CDV and/or the occurrence of less differentiated astrocytes representing a permanent source for virus infection and spread in advanced lesions of DL.