F
Fred A. Mellon
Researcher at Norwich Research Park
Publications - 42
Citations - 4029
Fred A. Mellon is an academic researcher from Norwich Research Park. The author has contributed to research in topics: Mass spectrometry & Tandem mass spectrometry. The author has an hindex of 28, co-authored 42 publications receiving 3781 citations. Previous affiliations of Fred A. Mellon include University of Leeds & Scottish Crop Research Institute.
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Journal ArticleDOI
Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L.
Richard N. Bennett,Fred A. Mellon,Nikolaus Foidl,John H Pratt,M.Susan DuPont,Lionel Perkins,Paul A. Kroon +6 more
TL;DR: Tissues of M. oleifera and M. stenopetala and leaves of both species contained quercetin 3-O-rhamnoglucoside (rutin) and 5-caffeoylquinic acid, and proanthocyanidins nor anthocyanins were detected in any of the tissues of either species.
Journal ArticleDOI
Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin
Andrea J. Day,Fred A. Mellon,Denis Barron,Géraldine Sarrazin,Michael R. A. Morgan,Gary Williamson +5 more
TL;DR: It is shown that quercetin glucosides are not present in plasma of human subjects 1.5 h after consumption of onions (a rich source of flavonoid glucoside), and the existence of substitutions in the B and/or C ring of plasma quercets suggests that these conjugates will each have very different biological activities.
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Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
TL;DR: It is shown that HepG2 cells can absorb and turnover quercetin glucuronides and that human endogenous beta-glucuronidase activity could modulate the intracellular biological activities of dietary antioxidant flavonoids.
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Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.
Niclas Petri,Christer Tannergren,Birgit Holst,Birgit Holst,Fred A. Mellon,Yongping Bao,Geoff W. Plumb,Jim Bacon,Karen A. O'Leary,Karen A. O'Leary,Paul A. Kroon,Lars Knutson,Patrik Forsell,Thomas Eriksson,Hans Lennernäs,Gary Williamson,Gary Williamson +16 more
TL;DR: The results show that food components have the potential to modify drug metabolism in the human enterocyte in vivo very rapidly.
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Absorption of hydroxycinnamates in humans after high-bran cereal consumption.
TL;DR: The data show that ferulic and sinapic acids are taken up in humans from dietary high bran wheat but that absorption is limited and may originate only from the free and soluble portions present in the cereal.