Aad Tibben

TL;DR: The frequency of tau mutations in a large population-based study of FTD carried out in the Netherlands from January 1994 to June 1998 is reported, finding an intronic mutation at position +33 after exon 9, which is likely to affect the alternative splicing of t Tau.

TL;DR: The findings support the emerging consensus that genetic predisposition testing for BRCA1/2 does not pose major mental health risks, but the findings also show that the impact of prophylactic surgery on aspects such as body image and sexuality should not be underestimated, and that some women are at risk for high distress, and as a result, need more attentive care.

TL;DR: This document argues for a cautious expansion of the scope of prenatal screening to serious congenital and childhood disorders, only following sound validation studies and a comprehensive evaluation of all relevant aspects.

TL;DR: Caregivers of FTD patients were overall more distressed by the behaviour of their partners than were the caregivers of AD patients, underscoring the importance of differentiating between diagnostic groups and specific behavioural domains when focusing on caregiver reactions to problem behaviour.

TL;DR: A screening for the fragile X syndrome has been conducted in a representative sample of 3,352 individuals in schools and institutes for the mentally retarded in the southwestern Netherlands, by use of a brief physical examination and the DNA test.