F
Freddy E. Escorcia
Researcher at National Institutes of Health
Publications - 45
Citations - 1599
Freddy E. Escorcia is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 30 publications receiving 1349 citations. Previous affiliations of Freddy E. Escorcia include State University of New York System & Cornell University.
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Journal ArticleDOI
Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli
TL;DR: Two other Hfq-dependent small RNAs, DsrA and OxyS, are also stable when overall transcription is off, and unstable when it is not, suggesting that they, too, are degraded when their target mRNAs are available for pairing.
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Conscripts of the infinite armada: systemic cancer therapy using nanomaterials
TL;DR: Examples of different materials are discussed to illustrate interesting principles for development and future applications of these nanomaterial medicines with emphasis on the possible pharmacologic and safety hurdles for accomplishing therapeutic goals.
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Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer
Jennifer C. Villa,Jennifer C. Villa,Danica Chiu,Danica Chiu,Alissa H. Brandes,Alissa H. Brandes,Freddy E. Escorcia,Freddy E. Escorcia,Carlos H. Villa,Carlos H. Villa,William F. Maguire,William F. Maguire,Cheng-Jun Hu,Elisa de Stanchina,M. Celeste Simon,Sangram S. Sisodia,David A. Scheinberg,David A. Scheinberg,Yue-Ming Li,Yue-Ming Li +19 more
TL;DR: A mechanism in which γ-secretase can achieve temporal control through conditional interactions with regulatory proteins, such as Hif-1α, under select physiological and pathological conditions is revealed.
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Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery
J. Justin Mulvey,J. Justin Mulvey,Carlos H. Villa,Carlos H. Villa,Michael R. McDevitt,Freddy E. Escorcia,Freddy E. Escorcia,Emily Casey,David A. Scheinberg,David A. Scheinberg +9 more
TL;DR: It is shown that SWNTs can target tumours in a two-step approach in which nanotubes modified with morpholino oligonucleotide sequences bind to cancer cells that have been pre-targeted with antibodies modified with oligon nucleotide strands complementary to those on the nanot tubes.
Journal ArticleDOI
Synthesis and biodistribution of oligonucleotide-functionalized, tumor-targetable carbon nanotubes.
Carlos H. Villa,Michael R. McDevitt,Freddy E. Escorcia,Diego A. Rey,Magnus Bergkvist,Carl A. Batt,David A. Scheinberg +6 more
TL;DR: The functionalized SWNT using regioselective chemistries to confer capabilities of selective targeting using RGD ligands, radiotracing using radiometal chelates, and self- assembly using oligonucleotides should enable the synthesis of multifunctional SWNT capable of self-assembly in biological settings.