F
Frédéric Charlotte
Researcher at University of Paris
Publications - 315
Citations - 27482
Frédéric Charlotte is an academic researcher from University of Paris. The author has contributed to research in topics: Liver biopsy & Histiocytosis. The author has an hindex of 75, co-authored 295 publications receiving 24972 citations. Previous affiliations of Frédéric Charlotte include Centre national de la recherche scientifique & Oregon Health & Science University.
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Journal ArticleDOI
Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial.
Vlad Ratziu,Vlad Ratziu,Frédéric Charlotte,Carole Bernhardt,Philippe Giral,Marine Halbron,Gilles Lenaour,Agnès Hartmann‐Heurtier,Eric Bruckert,Thierry Poynard +9 more
TL;DR: Rosiglitazone has a substantial antisteatogenic effect in the first year of treatment without additional benefit with longer therapy despite a maintained effect on insulin sensitivity and transaminase levels, suggesting that improving insulin sensitivity might not be sufficient in NASH and that additional targets of therapy for liver injury should be explored.
Journal ArticleDOI
Prospective Analysis of Discordant Results between Biochemical Markers and Biopsy in Patients with Chronic Hepatitis C
Thierry Poynard,Mona Munteanu,Françoise Imbert-Bismut,Frédéric Charlotte,Dominique Thabut,Sophie Le Calvez,Djamila Messous,Vincent Thibault,Yves Benhamou,Joseph Moussalli,Vlad Ratziu +10 more
TL;DR: The size of liver biopsy is adequate in only a minor proportion of patients with chronic hepatitis C and when biopsy and marker results are discordant, a reason can be identified in more than two-thirds of cases and biopsy failure is >7 times more common than diagnostic failure of markers.
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis
Thierry Poynard,Vlad Ratziu,Sylvie Naveau,Dominique Thabut,Frédéric Charlotte,Djamila Messous,Dominique Capron,Annie Abella,J. Massard,Yen Ngo,Mona Munteanu,A. Mercadier,Michael Manns,Janice K. Albrecht +13 more
TL;DR: SteatoTest is a simple and non-invasive quantitative estimate of liver steatosis and may reduce the need for liver biopsy, particularly in patients with metabolic risk factor.
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Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity.
Philippe Mathurin,Joseph Moussalli,Jean-François Cadranel,Vincent Thibault,Frédéric Charlotte,Patrice Dumouchel,A. Cazier,Jean-Marie Huraux,Bruno Devergie,Michel Vidaud,Pierre Opolon,Thierry Poynard +11 more
TL;DR: H hepatitis C virus patients with normal ALT showed weaker histological activity and lower fibrosis scores, and the progression rate of fibrosis was twice as slow as in HCV patients with elevated ALT, which was associated with high alcohol consumption.
Journal ArticleDOI
Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma
Hongtao Ye,Hongxiang Liu,Ayoma D. Attygalle,Andrew Wotherspoon,Andrew G. Nicholson,Frédéric Charlotte,Véronique Leblond,Paul M. Speight,John R. Goodlad,Anne Lavergne-Slove,José I. Martín-Subero,Reiner Siebert,Ahmet Dogan,Peter G. Isaacson,Ming-Qing Du +14 more
TL;DR: Neutrophil infiltration was prominent in H pylori-associated gastritis but not in lymphoepithelial sialadenitis and Hashimoto thyroiditis, suggesting that Oxidative damage might play a role in development of t(11;18)(q21; q21).