Journal ArticleDOI
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
Krisztina M. Zsebo,David A. Williams,Edwin N. Geissler,Virginia C. Broudy,Francis Hall Martin,Harry L. Atkins,Rou Yin Hsu,Neal C. Birkett,Kenneth H. Okino,Murdock Douglas C,Frederick W. Jacobsen,Keith Langley,Kent A. Smith,Takashi Takeish,Bruce M. Cattanach,Stephen J. Galli,Sidney Vaughn Suggs +16 more
TLDR
In vivo administration of SCF can reverse the macrocytic anemia and locally repair the mast cell deficiency of Sl/Sld mice and provide biological and physical evidence that SCF is a ligand for the c-kit receptor.About:
This article is published in Cell.The article was published on 1990-10-05. It has received 1485 citations till now. The article focuses on the topics: Stem cell factor & Receptor tyrosine kinase.read more
Citations
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Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor
Heikki Joensuu,Peter J. Roberts,Maarit Sarlomo-Rikala,Leif C. Andersson,Pekka Tervahartiala,David A. Tuveson,David A. Tuveson,Sandra Silberman,Renaud Capdeville,Sasa Dimitrijevic,Brian J. Druker,George D. Demetri +11 more
TL;DR: Gastrointestinal stromal tumors are a group of mesenchymal neoplasms that arise from precursors of the connective-tissue cells of the gastrointestinal tract that occur predominantly in middle-aged and older persons.
Journal ArticleDOI
Isolation of amniotic stem cell lines with potential for therapy.
Paolo De Coppi,Georg Bartsch,M. Minhaj Siddiqui,Tao Xu,Cesar C. Santos,Laura Perin,Gustavo Mostoslavsky,Ang line C. Serre,Evan Y. Snyder,James J. Yoo,Mark E. Furth,Shay Soker,Anthony Atala +12 more
TL;DR: The isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express embryonic and adult stem cell markers are reported and examples of differentiated cells derived from human AFS cells and displaying specialized functions include neuronal lineage cells secreting the neurotransmitter L-glutamate or expressing G-protein-gated inwardly rectifying potassium channels.
Journal ArticleDOI
The biology of hair follicles.
Ralf Paus,George Cotsarelis +1 more
TL;DR: Progress in understanding of the biology and pathology of hair follicles should lead to more effective therapies for disorders of hair growth, and few drugs that are effective for these purposes are available.
Journal ArticleDOI
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis.
Michael L. Mucenski,Kersten McLain,Ann B. Kier,Steven H. Swerdlow,Claire M. Schreiner,Thomas A. Miller,Daniel W. Pietryga,William J. Scott,S. Steven Potter +8 more
TL;DR: Analysis indicated that embryonic erythropoiesis, which occurs in the yolk sac, was not impaired by the c-myb alteration, but adult-type erythropsy was greatly diminished in c-Myb mutants, which is compatible with a role for c- myb in maintaining the proliferative state of hematopoietic progenitor cells.
Journal ArticleDOI
Hematopoietic commitment during embryonic stem cell differentiation in culture.
TL;DR: The kinetics of precursor development, as well as the growth factor responsiveness of these early cells, is similar to that found in the yolk sac and early fetal liver, indicating that the onset of hematopoiesis within the EBs parallels that finding in the embryo.
References
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Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
TL;DR: A technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, and these "oligolabeled" DNA fragments serve as efficient probes in filter hybridization experiments.
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
TL;DR: In this article, a technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, where DNA fragments are purified from agarose gels directly by ethanol precipitation and are then denatured and labeled with the large fragment of DNA polymerase I, using random oligonucleotides as primers.
Journal ArticleDOI
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
Randall Keichi Saiki,David H. Gelfand,Susanne Stoffel,Stephen J. Scharf,Russell Higuchi,Glenn Thomas Horn,Kary B. Mullis,Henry A. Erlich +7 more
TL;DR: A thermostable DNA polymerase was used in an in vitro DNA amplification procedure, the polymerase chain reaction, which significantly improves the specificity, yield, sensitivity, and length of products that can be amplified.
Journal ArticleDOI
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
W M Hunter,F. C. Greenwood +1 more
TL;DR: Current procedures for the immunological assay of protein hormones in human plasma require the routine preparation of hormones labelled with iodine-131 of high specific activity, and this work demonstrates the importance of knowing the carrier and removal status of iodine.