F
Frédérique Jacobs
Researcher at Université libre de Bruxelles
Publications - 145
Citations - 7765
Frédérique Jacobs is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Population & Therapeutic drug monitoring. The author has an hindex of 43, co-authored 142 publications receiving 7016 citations.
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Journal ArticleDOI
Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial
Ernst-Ruediger Kuse,Ploenchan Chetchotisakd,Clovis Arns da Cunha,Markus Ruhnke,Carlos H. Barrios,D Raghunadharao,Jagdev Singh Sekhon,Antonio Freire,V Ramasubramanian,Ignace Demeyer,Marcio Nucci,Amorn Leelarasamee,Frédérique Jacobs,Johan Decruyenaere,Didier Pittet,Andrew J. Ullmann,Luis Ostrosky-Zeichner,Olivier Lortholary,Sonja Koblinger,Heike Diekmann-Berndt,Oliver A. Cornely +20 more
TL;DR: Micafungin was as effective as--and caused fewer adverse events than--liposomal amphotericin B as first-line treatment of candidaemia and invasive candidosis.
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Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.
Narcisa Mesaros,Patrice Nordmann,Patrick Plésiat,M. Roussel-Delvallez,J. Van Eldere,Youri Glupczynski,Y. Van Laethem,Frédérique Jacobs,Patrick Lebecque,Anne Malfroot,P. M. Tulkens,F. Van Bambeke +11 more
TL;DR: Among broad-spectrum antibiotics in development, ceftobiprole, sitafloxacin and doripenem show interesting in-vitro activity, although the first two molecules have been evaluated in clinics only against Gram-positive organisms.
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A randomized comparison of liposomal versus conventional amphotericin B for the treatment of pyrexia of unknown origin in neutropenic patients.
H. G. Prentice,Ian Hann,Raoul Herbrecht,Michel Aoun,S. Kvaloy,Daniel Catovsky,CR Pinkerton,Steve Schey,Frédérique Jacobs,Anthony Oakhill,Richard F. Stevens,P. J. Darbyshire,Brenda Gibson +12 more
TL;DR: In both the paediatric and adult populations, L‐AMB treated patients had a 2–6‐fold decrease in the incidence of test‐drug‐related side‐effects, compared to c‐ AMB.
Journal ArticleDOI
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock.
Fabio Silvio Taccone,Pierre-François Laterre,Thierry Dugernier,Herbert D. Spapen,Isabelle Delattre,Xavier Wittebole,Daniel De Backer,Brice Layeux,Pierre Wallemacq,Jean Louis Vincent,Frédérique Jacobs +10 more
TL;DR: Standard dosage regimens for piperacillin-tazobactam, ceftazidime and cefepime may be insufficient to empirically cover less susceptible pathogens in the early phase of severe sepsis and septic shock.
Journal ArticleDOI
Deep dermatophytosis and inherited CARD9 deficiency.
Fanny Lanternier,Saad Pathan,Quentin B. Vincent,Luyan Liu,Sophie Cypowyj,Carolina Prando,Mélanie Migaud,Lynda Taibi,Aomar Ammar-Khodja,Omar Boudghene Stambouli,Boumediene Guellil,Frédérique Jacobs,Jean-Christophe Goffard,Kinda Schepers,Véronique Del Marmol,Lobna Boussofara,Mohamed Denguezli,Molka Larif,Hervé Bachelez,Laurence Michel,Gérard Lefranc,Rod Hay,Grégory Jouvion,Fabrice Chrétien,Sylvie Fraitag,Marie-Elisabeth Bougnoux,Merad Boudia,Laurent Abel,Olivier Lortholary,Jean-Laurent Casanova,Capucine Picard,Bodo Grimbacher,Anne Puel +32 more
TL;DR: Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency, and the familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance.