M
Mélanie Migaud
Researcher at French Institute of Health and Medical Research
Publications - 65
Citations - 6944
Mélanie Migaud is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Chronic mucocutaneous candidiasis & Immunology. The author has an hindex of 25, co-authored 55 publications receiving 4703 citations. Previous affiliations of Mélanie Migaud include Necker-Enfants Malades Hospital & University of Paris.
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Journal ArticleDOI
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Paul Bastard,Paul Bastard,Paul Bastard,Lindsey B. Rosen,Qian Zhang,Eleftherios Michailidis,Hans-Heinrich Hoffmann,Yu Zhang,Karim Dorgham,Quentin Philippot,Quentin Philippot,Jérémie Rosain,Jérémie Rosain,Vivien Béziat,Vivien Béziat,Vivien Béziat,Jeremy Manry,Jeremy Manry,Elana Shaw,Liis Haljasmägi,Pärt Peterson,Lazaro Lorenzo,Lazaro Lorenzo,Lucy Bizien,Lucy Bizien,Sophie Trouillet-Assant,Kerry Dobbs,Adriana Almeida de Jesus,Alexandre Belot,Anne Kallaste,Emilie Catherinot,Yacine Tandjaoui-Lambiotte,Jérémie Le Pen,Gaspard Kerner,Gaspard Kerner,Benedetta Bigio,Yoann Seeleuthner,Yoann Seeleuthner,Rui Yang,Alexandre Bolze,András N Spaan,András N Spaan,Ottavia M. Delmonte,Michael S. Abers,Alessandro Aiuti,Giorgio Casari,Vito Lampasona,Lorenzo Piemonti,Fabio Ciceri,Kaya Bilguvar,Richard P. Lifton,Richard P. Lifton,Marc Vasse,David M. Smadja,Mélanie Migaud,Mélanie Migaud,Jérôme Hadjadj,Benjamin Terrier,Darragh Duffy,Lluis Quintana-Murci,Lluis Quintana-Murci,Diederik van de Beek,Lucie Roussel,Donald C. Vinh,Stuart G. Tangye,Stuart G. Tangye,Filomeen Haerynck,David Dalmau,Javier Martinez-Picado,Javier Martinez-Picado,Petter Brodin,Petter Brodin,Michel C. Nussenzweig,Michel C. Nussenzweig,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Carlos Rodríguez-Gallego,Guillaume Vogt,Trine H. Mogensen,Trine H. Mogensen,Andrew J. Oler,Jingwen Gu,Peter D. Burbelo,Jeffrey I. Cohen,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Patrick Rossignol,Julien Mayaux,Frédéric Rieux-Laucat,Eystein S. Husebye,Eystein S. Husebye,Eystein S. Husebye,Francesca Fusco,Matilde Valeria Ursini,Luisa Imberti,Alessandra Sottini,Simone Paghera,Eugenia Quiros-Roldan,Camillo Rossi,Riccardo Castagnoli,Daniela Montagna,Amelia Licari,Gian Luigi Marseglia,Xavier Duval,Jade Ghosn,Hgid Lab,Covid Clinicians,Covid-Storm Clinicians§,CoV-Contact Cohort§,Amsterdam Umc Covid Biobank,Amsterdam Umc Covid Biobank,Amsterdam Umc Covid Biobank,Covid Human Genetic Effort,John S. Tsang,Raphaela Goldbach-Mansky,Kai Kisand,Michail S. Lionakis,Anne Puel,Anne Puel,Anne Puel,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Steven M. Holland,Guy Gorochov,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Charles M. Rice,Aurélie Cobat,Aurélie Cobat,Aurélie Cobat,Luigi D. Notarangelo,Laurent Abel,Laurent Abel,Laurent Abel,Helen C. Su,Jean-Laurent Casanova +140 more
TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.
Journal ArticleDOI
Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Anne Puel,Sophie Cypowyj,Jacinta Bustamante,Jill F. Wright,Luyan Liu,Hye Kyung Lim,Mélanie Migaud,Laura Israel,Maya Chrabieh,Magali Audry,Matthew Gumbleton,Antoine Toulon,Christine Bodemer,Jamila El-Baghdadi,Matthew J. Whitters,Theresa Paradis,Jonathan Brooks,Mary Collins,Neil M. Wolfman,Saleh Al-Muhsen,Miguel Galicchio,Laurent Abel,Laurent Abel,Capucine Picard,Jean-Laurent Casanova +24 more
TL;DR: These experiments of nature indicate that human IL-17A andIL-17F are essential for mucocutaneous immunity against C. albicans, but otherwise largely redundant.
Journal ArticleDOI
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
Luyan Liu,Satoshi Okada,Xiao-Fei Kong,Alexandra Y. Kreins,Sophie Cypowyj,Avinash Abhyankar,Julie Toubiana,Yuval Itan,Magali Audry,Patrick Nitschke,Cécile Masson,Beáta Tóth,Jérome Flatot,Mélanie Migaud,Maya Chrabieh,Tatiana Kochetkov,Alexandre Bolze,Alexandre Bolze,Alessandro Borghesi,Antoine Toulon,J. Hiller,Stefanie Eyerich,Kilian Eyerich,Vera Gulácsy,Ludmyla Chernyshova,Viktor P. Chernyshov,Anastasia Bondarenko,Rosa María Cortés Grimaldo,Lizbeth Blancas-Galicia,Ileana Maria Madrigal Beas,Joachim Roesler,Klaus Magdorf,Dan Engelhard,Caroline Thumerelle,Pierre-Régis Burgel,Miriam Hoernes,Barbara Drexel,Reinhard Seger,Theresia Kusuma,Annette Jansson,Julie Sawalle-Belohradsky,Bernd H. Belohradsky,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Jacinta Bustamante,Mélanie Bué,Nathan Karin,Gizi Wildbaum,Christine Bodemer,Olivier Lortholary,Alain Fischer,Stéphane Blanche,Saleh Al-Muhsen,Janine Reichenbach,Masao Kobayashi,Francisco Espinosa Rosales,Carlos Torres Lozano,Sara Sebnem Kilic,Matías Oleastro,Amos Etzioni,Claudia Traidl-Hoffmann,Ellen D. Renner,Laurent Abel,Laurent Abel,Capucine Picard,Capucine Picard,László Maródi,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Anne Puel,Jean-Laurent Casanova +70 more
TL;DR: Whole-exome sequencing reveals activating STAT1 mutations in some patients with autosomal dominant chronic mucocutaneous candidiasis disease.
Journal ArticleDOI
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
Satoshi Okada,Satoshi Okada,Janet Markle,Elissa K. Deenick,Elissa K. Deenick,Federico Mele,Dina Averbuch,M. Lagos,M. Lagos,Mohammed Alzahrani,Saleh Al-Muhsen,Rabih Halwani,Cindy S. Ma,Cindy S. Ma,Natalie Wong,Claire Soudais,Lauren A. Henderson,Hiyam Marzouqa,Jamal Shamma,Marcela Gonzalez,Rubén Martínez-Barricarte,Chizuru Okada,Danielle T. Avery,Daniela Latorre,Caroline Deswarte,Caroline Deswarte,Fabienne Jabot-Hanin,Fabienne Jabot-Hanin,Egídio Torrado,Jeffrey J. Fountain,Aziz Belkadi,Aziz Belkadi,Yuval Itan,Bertrand Boisson,Mélanie Migaud,Mélanie Migaud,Cecilia S. Lindestam Arlehamn,Alessandro Sette,Sylvain Breton,James McCluskey,Jamie Rossjohn,Jamie Rossjohn,Jamie Rossjohn,Jean-Pierre de Villartay,Despina Moshous,Sophie Hambleton,Sylvain Latour,Peter D. Arkwright,Capucine Picard,Olivier Lantz,Dan Engelhard,Masao Kobayashi,Laurent Abel,Laurent Abel,Laurent Abel,Andrea M. Cooper,Luigi D. Notarangelo,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Anne Puel,Anne Puel,Anne Puel,Federica Sallusto,Jacinta Bustamante,Stuart G. Tangye,Stuart G. Tangye,Jean-Laurent Casanova +67 more
TL;DR: People with loss-of-function mutations in the transcription factor RORC exhibit a surprising susceptibility to Mycobacterium, whereas inborn errors of interferon-γ (IFN-γ) immunity underlie mycobacterial disease.
Journal ArticleDOI
Deep dermatophytosis and inherited CARD9 deficiency.
Fanny Lanternier,Saad Pathan,Quentin B. Vincent,Luyan Liu,Sophie Cypowyj,Carolina Prando,Mélanie Migaud,Lynda Taibi,Aomar Ammar-Khodja,Omar Boudghene Stambouli,Boumediene Guellil,Frédérique Jacobs,Jean-Christophe Goffard,Kinda Schepers,Véronique Del Marmol,Lobna Boussofara,Mohamed Denguezli,Molka Larif,Hervé Bachelez,Laurence Michel,Gérard Lefranc,Rod Hay,Grégory Jouvion,Fabrice Chrétien,Sylvie Fraitag,Marie-Elisabeth Bougnoux,Merad Boudia,Laurent Abel,Olivier Lortholary,Jean-Laurent Casanova,Capucine Picard,Bodo Grimbacher,Anne Puel +32 more
TL;DR: Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency, and the familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance.