S
Sophie Cypowyj
Researcher at Rockefeller University
Publications - 19
Citations - 3681
Sophie Cypowyj is an academic researcher from Rockefeller University. The author has contributed to research in topics: Chronic mucocutaneous candidiasis & Mucocutaneous zone. The author has an hindex of 18, co-authored 19 publications receiving 3294 citations.
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Journal ArticleDOI
Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Anne Puel,Sophie Cypowyj,Jacinta Bustamante,Jill F. Wright,Luyan Liu,Hye Kyung Lim,Mélanie Migaud,Laura Israel,Maya Chrabieh,Magali Audry,Matthew Gumbleton,Antoine Toulon,Christine Bodemer,Jamila El-Baghdadi,Matthew J. Whitters,Theresa Paradis,Jonathan Brooks,Mary Collins,Neil M. Wolfman,Saleh Al-Muhsen,Miguel Galicchio,Laurent Abel,Laurent Abel,Capucine Picard,Jean-Laurent Casanova +24 more
TL;DR: These experiments of nature indicate that human IL-17A andIL-17F are essential for mucocutaneous immunity against C. albicans, but otherwise largely redundant.
Journal ArticleDOI
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
Luyan Liu,Satoshi Okada,Xiao-Fei Kong,Alexandra Y. Kreins,Sophie Cypowyj,Avinash Abhyankar,Julie Toubiana,Yuval Itan,Magali Audry,Patrick Nitschke,Cécile Masson,Beáta Tóth,Jérome Flatot,Mélanie Migaud,Maya Chrabieh,Tatiana Kochetkov,Alexandre Bolze,Alexandre Bolze,Alessandro Borghesi,Antoine Toulon,J. Hiller,Stefanie Eyerich,Kilian Eyerich,Vera Gulácsy,Ludmyla Chernyshova,Viktor P. Chernyshov,Anastasia Bondarenko,Rosa María Cortés Grimaldo,Lizbeth Blancas-Galicia,Ileana Maria Madrigal Beas,Joachim Roesler,Klaus Magdorf,Dan Engelhard,Caroline Thumerelle,Pierre-Régis Burgel,Miriam Hoernes,Barbara Drexel,Reinhard Seger,Theresia Kusuma,Annette Jansson,Julie Sawalle-Belohradsky,Bernd H. Belohradsky,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Jacinta Bustamante,Mélanie Bué,Nathan Karin,Gizi Wildbaum,Christine Bodemer,Olivier Lortholary,Alain Fischer,Stéphane Blanche,Saleh Al-Muhsen,Janine Reichenbach,Masao Kobayashi,Francisco Espinosa Rosales,Carlos Torres Lozano,Sara Sebnem Kilic,Matías Oleastro,Amos Etzioni,Claudia Traidl-Hoffmann,Ellen D. Renner,Laurent Abel,Laurent Abel,Capucine Picard,Capucine Picard,László Maródi,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Anne Puel,Jean-Laurent Casanova +70 more
TL;DR: Whole-exome sequencing reveals activating STAT1 mutations in some patients with autosomal dominant chronic mucocutaneous candidiasis disease.
Journal ArticleDOI
Deep dermatophytosis and inherited CARD9 deficiency.
Fanny Lanternier,Saad Pathan,Quentin B. Vincent,Luyan Liu,Sophie Cypowyj,Carolina Prando,Mélanie Migaud,Lynda Taibi,Aomar Ammar-Khodja,Omar Boudghene Stambouli,Boumediene Guellil,Frédérique Jacobs,Jean-Christophe Goffard,Kinda Schepers,Véronique Del Marmol,Lobna Boussofara,Mohamed Denguezli,Molka Larif,Hervé Bachelez,Laurence Michel,Gérard Lefranc,Rod Hay,Grégory Jouvion,Fabrice Chrétien,Sylvie Fraitag,Marie-Elisabeth Bougnoux,Merad Boudia,Laurent Abel,Olivier Lortholary,Jean-Laurent Casanova,Capucine Picard,Bodo Grimbacher,Anne Puel +32 more
TL;DR: Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency, and the familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance.
Journal ArticleDOI
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis
TL;DR: Inborn errors of human IL-17 immunity underlie CMC and may account for CMC in other settings, including patients with acquired immunodeficiency, according to recent findings.
Journal ArticleDOI
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes.
Stéphanie Boisson-Dupuis,Xiao-Fei Kong,Satoshi Okada,Sophie Cypowyj,Anne Puel,Anne Puel,Laurent Abel,Laurent Abel,Laurent Abel,Jean-Laurent Casanova +9 more
TL;DR: Germline mutations in human STAT1 define four distinct clinical disorders, various combinations of viral, mycobacterial and fungal infections are therefore allelic at the humanSTAT1 locus.