Fredrik Eriksson

TL;DR: Age-related accumulation of copy-number variation in the nuclear genomes in vivo and frequency changes for both megabase- and kilobase-range variants are described and recurrent rearrangements uncovered here are candidates for common age-related defects in human blood cells.

TL;DR: Lower levels of pathogenic α-synuclein demonstrated, and a reduction of motor dysfunction in transgenic mice upon peripheral administration of mAb47 was indicated, suggest immunotherapy with antibodies targeting toxic α- synuclein species holds promise as a future disease-modifying treatment in Parkinson's disease and related disorders.

TL;DR: This study confirms previous findings that local administration of low-dose anti- CTLA4 antibody generates sustained antitumor effects and provides rationale to devise ultrasound-guided intratumoral anti-CTLA4 antibodies injection regimens to treat patients with pancreatic adenocarcinoma and other types of solid tumors.

TL;DR: Safety, clinical efficacy and immunogenicity of a DNA vaccine coding for rhesus prostate specific antigen (PSA) delivered by intradermal injection and skin electroporation and T-cell reactivity observed in patients with biochemical relapse of prostate cancer without macroscopic disease are tested.

TL;DR: This article characterized the binding properties of lecanemab, aducanumab, and gantenerumab to different Aβ species with inhibition ELISA, immunodepletion, and surface plasmon resonance.