Showing papers in "Vaccine in 2013"

TL;DR: It is shown that test-negative studies of influenza VE can produce biased VE estimates if they include persons seeking care for ARI when influenza is not circulating or do not adjust for calendar time.

TL;DR: This paper outlines the consensus position of the working group, the evidence supporting this position, areas worthy of future research, and the epidemiological role of carriage studies, and describes the collection, transport and storage of nasopharyngeal samples.

TL;DR: There must be ongoing efforts including international advocacy to achieve widespread-optimally universal-implementation of HPV prevention strategies in both developed and developing countries.

TL;DR: A systematic review of four online databases to identify interventional studies and used criteria recommended by the WHO's Strategic Advisory Group of Experts on immunization for the quality assessment of studies.

TL;DR: The available data suggest that the serotype distribution of GBS isolates is similar in Africa, Western Pacific, Europe, the Americas and the Eastern Mediterranean regions and has not changed over the past 30 years.

TL;DR: Under sets of increasingly general assumptions, it is found that the case test-negative design can provide unbiased VE estimates, but if vaccinated cases are less severely ill and seek care less frequently than unvaccinated cases, then an appropriate adjustment for illness severity is required to avoid bias in effectiveness estimates.

TL;DR: The US experience demonstrates that universal screening and IAP for GBS-colonized women comprise a highly effective strategy against early-onset GBS infections, and Maximizing adherence to recommended practices holds promise to further reduce the burden of early-ONSET GBS disease.

TL;DR: The safety signal of increased narcolepsy diagnoses following the start of the pandemic vaccination campaign as observed in Sweden and Finland could be observed with this approach.

TL;DR: Variation was found across vaccines, however, sensitivity and specificity did not vary substantially by either age or race/ethnicity; Hispanics were 2.7 times more likely to claim receipt of vaccination compared to whites.

TL;DR: This data indicates that there are opportunities to facilitate the chance of achieving an RSV vaccine in 4 potential target populations and additional disease burden data is needed to appropriately prioritizeRSV vaccine research.

TL;DR: PCV13 induces a greater functional immune response than PPSV23 for the majority of serotypes covered by PCV 13, suggesting that PCV13 could offer immunological advantages over PPSv23 for prevention of vaccine-type pneumococcal infection.

TL;DR: The review identified more than 60 reports or evaluations of vaccine-preventable infectious-disease outbreaks that occurred within religious communities or that spread from them to broader communities, finding that ostensibly religious reasons to decline immunization actually reflected concerns about vaccine safety or personal beliefs among a social network of people organized around a faith community.

TL;DR: MTBVAC is an attenuated Mycobacterium tuberculosis vaccine candidate genetically engineered to fulfil the Geneva consensus requirements to enter human clinical trials and is believed to be the first live attenuated M. tuberculosis vaccine to enter clinical evaluation.

TL;DR: The incidence of VT-IPD decreased in the targeted (<5 years) and non-targeted age groups since PCV7 introduction and further decreased after the replacement with PCV13, suggesting that serotype replacement is again occurring and that non-vaccinated individuals profit through indirect protection.

TL;DR: Strategies to reduce the excessive burden of HPV-related diseases in SSA include age-appropriate prophylactic HPV vaccination, cervical cancer prevention services for women of the reproductive ages, and control of HIV/AIDS.

TL;DR: In adults aged 70 years and older previously vaccinated with P PSV23, PCV13 was significantly more immunogenic than PPSV23 for most of the common serotypes and for serotype 6A.

TL;DR: Standardized cost-effectiveness studies of influenza vaccination of WHO-recommended risk groups' methods are urgently needed because decision makers in lower income countries lack economic data to support influenza vaccine policy decisions, especially of pregnant women.

TL;DR: The data suggest that the greatest potential impact of pertussis vaccination of adults to prevent severe disease in young infants comes from vaccinating mothers, followed by fathers, with grandparents having a minor role.

TL;DR: VPM1002 was safe and immunogenic for B-cell and T-cell responses and hence will be brought forward through the clinical trial pipeline.

TL;DR: Indirect PCV impact on VT-IPD and VT-carriage has been significant and impact on carriage should be considered for inclusion in the PCV licensure process as a predictor of indirect effects.

TL;DR: Pharmaceutical advertising campaigns could explain why awareness of HPV and HPV vaccine is higher in the US and this has helped to get some important messages across, but significant gaps in HPV knowledge remain across all three countries.

TL;DR: Only the fully formulated MF59 emulsion induces all the established hallmarks of innate and adaptive immune activation, which includes activation of genes indicative of transendothelial cell migration, strong influx of immune cells into the injection site and their enhanced antigen uptake and transport to the lymph nodes.

TL;DR: Findings are regarded as substantial evidence for the ability of influenza vaccine to reduce the risk of influenza infection and influenza-related disease and death in the elderly.

TL;DR: Modified Vaccinia virus Ankara (MVA) is a replication-deficient and attenuated derivative, also used in the smallpox eradication campaign and now being developed as a recombinant viral vector to produce vaccines against infectious diseases and cancer.

TL;DR: A review of vaccine development efforts can be found in this article, with an emphasis on events that occurred during the earlier years, and the goal is to provide younger generations of scientists with information and inspiration to continue the search for an HIV vaccine.

TL;DR: In adults 50 to 64 years of age, initial vaccination with PCV13 establishes an immune state that results in recall anti-pneumococcal responses upon subsequent vaccination with either conjugated or free polysaccharide vaccine.

TL;DR: Overall, concordance, sensitivity, specificity, positive and negative predictive value showed poor agreement, providing evidence that household vaccination information may not be reliable, and should be interpreted with care.

TL;DR: A recombinant live-attenuated measles vaccine expressingCHIKV virus-like particles comprising capsid and envelope structural proteins from the recent CHIKV strain La Reunion could make a safe and effective vaccine against chikungunya that deserves to be further tested in human trials.

TL;DR: Over the next decade, vaccine supply and logistics systems in nearly all developing countries will require significant investments of time and resources from global and national partners, donors, and governments.