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Gabriel C. Lander

Researcher at Scripps Research Institute

Publications -  138
Citations -  10506

Gabriel C. Lander is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 43, co-authored 123 publications receiving 8748 citations. Previous affiliations of Gabriel C. Lander include California Institute of Technology & Scripps Health.

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Appion: an integrated, database-driven pipeline to facilitate EM image processing.

TL;DR: The vision for this technique is to provide a straightforward manner in which users can proceed from raw data to a reliable 3D reconstruction through a pipeline that both facilitates management of the processing steps and makes the results at each step more transparent.
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Complete subunit architecture of the proteasome regulatory particle

TL;DR: These studies reveal the spatial arrangement of ubiquitin receptors, deubiquitinating enzymes and the protein unfolding machinery at subnanometre resolution, outlining the substrate’s path to degradation.
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High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis.

TL;DR: Insight is provided into the mechanism of dynamic instability, based on high-resolution cryo-EM structures of dynamic microtubule and microtubules stabilized by GMPCPP or Taxol, that hydrolysis leads to a compaction around the E-site nucleotide at longitudinal interfaces, as well as movement of the α-tubulin intermediate domain and H7 helix.
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Functional Annotation of the Arabidopsis Genome Using Controlled Vocabularies

TL;DR: The process ofArabidopsis functional annotation is described using a variety of data sources and several ways in which this information can be accessed and used to infer knowledge about Arabidopsis and other plant species are illustrated.