G
Gabriel C. Lander
Researcher at Scripps Research Institute
Publications - 138
Citations - 10506
Gabriel C. Lander is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 43, co-authored 123 publications receiving 8748 citations. Previous affiliations of Gabriel C. Lander include California Institute of Technology & Scripps Health.
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Journal ArticleDOI
Appion: an integrated, database-driven pipeline to facilitate EM image processing.
Gabriel C. Lander,Scott M. Stagg,Neil R. Voss,Anchi Cheng,Denis Fellmann,James Pulokas,Craig Yoshioka,Christopher Irving,Anke M. Mulder,Pick-Wei Lau,Dmitry Lyumkis,Clinton S. Potter,Bridget Carragher +12 more
TL;DR: The vision for this technique is to provide a straightforward manner in which users can proceed from raw data to a reliable 3D reconstruction through a pipeline that both facilitates management of the processing steps and makes the results at each step more transparent.
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The Arabidopsis Information Resource (TAIR): a model organism database providing a centralized, curated gateway to Arabidopsis biology, research materials and community
Seung Y. Rhee,William D. Beavis,Tanya Z. Berardini,Guanghong Chen,David A. Dixon,Aisling Doyle,Margarita Garcia-Hernandez,Eva Huala,Gabriel C. Lander,Mary Montoya,Neil A. Miller,Lukas A. Mueller,Suparna Mundodi,Leonore Reiser,Julie Tacklind,Dan C. Weems,Yihe Wu,Iris Xu,Daniel Yoo,Jungwon Yoon,Peifen Zhang +20 more
TL;DR: New information include sequence polymorphisms including alleles, germplasms and phenotypes, Gene Ontology annotations, gene families, protein information, metabolic pathways, gene expression data from microarray experiments and seed and DNA stocks.
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Complete subunit architecture of the proteasome regulatory particle
Gabriel C. Lander,Eric Estrin,Mary E Matyskiela,Charlene Bashore,Eva Nogales,Eva Nogales,Andreas Martin +6 more
TL;DR: These studies reveal the spatial arrangement of ubiquitin receptors, deubiquitinating enzymes and the protein unfolding machinery at subnanometre resolution, outlining the substrate’s path to degradation.
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High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis.
Gregory M. Alushin,Gabriel C. Lander,Elizabeth H. Kellogg,Rui Zhang,David Baker,Eva Nogales,Eva Nogales +6 more
TL;DR: Insight is provided into the mechanism of dynamic instability, based on high-resolution cryo-EM structures of dynamic microtubule and microtubules stabilized by GMPCPP or Taxol, that hydrolysis leads to a compaction around the E-site nucleotide at longitudinal interfaces, as well as movement of the α-tubulin intermediate domain and H7 helix.
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Functional Annotation of the Arabidopsis Genome Using Controlled Vocabularies
Tanya Z. Berardini,Suparna Mundodi,Leonore Reiser,Eva Huala,Margarita Garcia-Hernandez,Peifen Zhang,Lukas A. Mueller,Jungwoon Yoon,Aisling Doyle,Gabriel C. Lander,Nick Moseyko,Danny Yoo,Iris Xu,Brandon Zoeckler,Mary Montoya,Neil A. Miller,Dan C. Weems,Seung Y. Rhee +17 more
TL;DR: The process ofArabidopsis functional annotation is described using a variety of data sources and several ways in which this information can be accessed and used to infer knowledge about Arabidopsis and other plant species are illustrated.