G
Gaëlle Friocourt
Researcher at University of Western Brittany
Publications - 46
Citations - 3207
Gaëlle Friocourt is an academic researcher from University of Western Brittany. The author has contributed to research in topics: Lissencephaly & Doublecortin. The author has an hindex of 22, co-authored 40 publications receiving 2953 citations. Previous affiliations of Gaëlle Friocourt include European University of Brittany & Université Paris-Saclay.
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Journal ArticleDOI
Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
Fiona Francis,Annette Koulakoff,Dominique Boucher,Philippe Chafey,Bruce T. Schaar,M C Vinet,Gaëlle Friocourt,Nathalie McDonnell,Orly Reiner,Axel Kahn,Susan K. McConnell,Yoheved Berwald-Netter,Philippe Denoulet,Jamel Chelly +13 more
TL;DR: It is shown that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons, and Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neuron, and a strong axonal labeling is observed in differentiating neuron.
Journal ArticleDOI
ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation
Thierry Bienvenu,Karine Poirier,Gaëlle Friocourt,Nadia Bahi,Delphine Beaumont,Fabien Fauchereau,Lamia Ben Jeema,Ramzi Zemni,Marie Claude Vinet,Fiona Francis,Philippe Couvert,Marie Gomot,Claude Moraine,Hans van Bokhoven,Vera M. Kalscheuer,S Frints,Josef Gecz,Kanae Ohzaki,Habiba Chaabouni,Jean Pierre Fryns,Vincent Desportes,Cherif Beldjord,Jamel Chelly +22 more
TL;DR: The absence of detectable brain malformations in patients suggests that ARX may have an essential role, in mature neurons, required for the development of cognitive abilities.
Journal ArticleDOI
A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation
Ramzi Zemni,Thierry Bienvenu,M C Vinet,Abdelaziz Sefiani,Alain Carrié,Pierre Billuart,N. McDonell,Philippe Couvert,Fiona Francis,Philippe Chafey,F Fauchereau,Gaëlle Friocourt,des Portes,A. Cardona,Suzanna G M Frints,Alfons Meindl,Oliver Brandau,Nathalie Ronce,Claude Moraine,H Van Bokhoven,Hans-Hilger Ropers,Ralf Sudbrak,Axel Kahn,Jean-Pierre Fryns,Cherif Beldjord,Jamel Chelly +25 more
TL;DR: It is shown that the gene TM4SF2 at Xp11.4 is inactivated by the X breakpoint of an X;2 balanced translocation in a patient with MR, and it is speculated that through this interaction, TM4 SF2 might have a role in the control of neurite outgrowth.
Journal ArticleDOI
Doublecortin functions at the extremities of growing neuronal processes.
Gaëlle Friocourt,Annette Koulakoff,Philippe Chafey,Dominique Boucher,Fabien Fauchereau,Jamel Chelly,Fiona Francis +6 more
TL;DR: The observations summarized here favor the suggestion that whereas LIS1 may play a role in nuclear migration, Doublecortin is instead restricted to functions at the leading edge of the cell.
Journal ArticleDOI
Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration
Gaëlle Friocourt,Judy S. Liu,Mary Antypa,Sonja Rakic,Christopher A. Walsh,John G. Parnavelas +5 more
TL;DR: The importance of these genes in interneuron migration was confirmed by the finding that the cortices of D cx, Dclk, and Dcx/Dclk mutant mice contained a reduced number of such cells in the cortex and their distribution was different compared with wild-type controls, suggesting that DCX and DCLK have distinct roles in cortical interneurons migration.