Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
Fiona Francis,Annette Koulakoff,Dominique Boucher,Philippe Chafey,Bruce T. Schaar,M C Vinet,Gaëlle Friocourt,Nathalie McDonnell,Orly Reiner,Axel Kahn,Susan K. McConnell,Yoheved Berwald-Netter,Philippe Denoulet,Jamel Chelly +13 more
TLDR
It is shown that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons, and Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neuron, and a strong axonal labeling is observed in differentiating neuron.About:
This article is published in Neuron.The article was published on 1999-06-01 and is currently open access. It has received 982 citations till now. The article focuses on the topics: Doublecortin & Corticogenesis.read more
Citations
More filters
Journal ArticleDOI
Transient expression of doublecortin during adult neurogenesis
Jason Brown,Sebastien Couillard-Despres,Christiana M. Cooper-Kuhn,Jürgen Winkler,Jürgen Winkler,Ludwig Aigner,H. Georg Kuhn +6 more
TL;DR: The transient expression pattern of DCX in neuronal committed progenitor cells/neuroblasts indicates that DCX could be developed into a suitable marker for adult neurogenesis and may provide an alternative to BrdU labeling.
Journal ArticleDOI
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
TL;DR: Findings implicate the angiogenesis factor VEGF in neurogenesis as well in murine cerebral cortical cultures and in adult rat brain in vivo.
Journal ArticleDOI
Induction of neurogenesis in the neocortex of adult mice.
Sanjay S. Magavi,Blair R. Leavitt,Blair R. Leavitt,Blair R. Leavitt,Jeffrey D. Macklis,Jeffrey D. Macklis +5 more
TL;DR: It is shown that endogenous neural precursors can be induced in situ to differentiate into mature neurons, in regions of adult mammalian neocortex that do not normally undergo any neurogenesis.
Journal ArticleDOI
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity.
TL;DR: It is shown that LTP and LTD reversibly modify the phosphorylation of the AMPA receptor GluR1 subunit, and that identical stimulation conditions recruit different signal-transduction pathways depending on synaptic history.
Journal ArticleDOI
Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
Kunlin Jin,Manabu Minami,Jing Q. Lan,Xiao Ou Mao,Sophie Batteur,Roger P. Simon,David A. Greenberg +6 more
TL;DR: A role for ischemia-induced neurogenesis in what may be adaptive processes that contribute to recovery after stroke is supported.
References
More filters
Journal ArticleDOI
Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
TL;DR: The SVZa appears to constitute a specialized source of neuronal progenitor cells that differentiated into granule cells and periglomerular cells of the olfactory bulb-the two major types of interneurons.
Journal ArticleDOI
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
Gabriella D'Arcangelo,Graham G. Miao,Shu-Cheng Chen,Holly D. Soares,James I. Morgan,Tom Curran +5 more
TL;DR: The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
Journal ArticleDOI
Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesus
TL;DR: The cytology of the postmitotic migratory granule cell and its relationship to Bergmann glial processes was examined with Golgi staining and electron microscopy in the three cardinal planes in the developing cerebellar cortex of Macacus rhesus at various late fetal and early postnatal ages.
Journal ArticleDOI
Chain Migration of Neuronal Precursors
TL;DR: Electron microscopic analysis of serial sections showed that during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
Journal ArticleDOI
doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein
Joseph G. Gleeson,Joseph G. Gleeson,Kristina M. Allen,Jeremy W. Fox,Edward D Lamperti,Samuel F. Berkovic,Ingrid E. Scheffer,Edward C. Cooper,William B. Dobyns,Sharon R. Minnerath,M. Elizabeth Ross,Christopher A. Walsh +11 more
TL;DR: A novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Doublecortin, which may define an Abl-dependent pathway regulating neuronal migration.