G
Gahininath Y. Bharate
Researcher at Sojo University
Publications - 9
Citations - 1175
Gahininath Y. Bharate is an academic researcher from Sojo University. The author has contributed to research in topics: Xanthine oxidase inhibitor & Xanthine oxidase. The author has an hindex of 5, co-authored 7 publications receiving 1107 citations.
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Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
TL;DR: The EPR-effect appears as a universal phenomenon in solid tumors which warrants the development of other polymeric drugs or nanomedicine, and then advantages and problems of macromolecular drugs.
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The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34+/CD38+ and CD34+/CD38- AML progenitor cells.
Harald Herrmann,Michael Kneidinger,Sabine Cerny-Reiterer,Thomas Rülicke,Michael Willmann,Karoline V. Gleixner,Katharina Blatt,Gregor Hörmann,Barbara Peter,Puchit Samorapoompichit,Winfried F. Pickl,Gahininath Y. Bharate,Matthias Mayerhofer,W. R. Sperr,Hiroshi Maeda,Peter Valent +15 more
TL;DR: Evidence is provided that Hsp32 is constitutively expressed in primary leukemic cells in patients with acute myeloid leukemia (AML) and in various AML cell lines (HL60, U937, KG1), and that SMA-ZnPP inhibits cytokine-dependent proliferation of CD34+/CD38+ and CD34-/CD34- AML progenitor cells in vitro in all patients.
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Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases.
Jun Fang,Jun Fang,Hongzhuan Yin,Long Liao,Haibo Qin,Fumiko Ueda,Kyoko Uemura,Kanami Eguchi,Gahininath Y. Bharate,Hiroshi Maeda +9 more
TL;DR: PEG-AHPP may be a potential candidate drug for ROS-related diseases including inflammatory bowel disease after synthesizing a water soluble polyethylene glycol (PEG) conjugate of AHPP that exhibited good water solubility, forming micelles in aqueous solution.
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Corrosion resistant hydrophobic coating using modified conducting polyaniline
Arindam Adhikari,Rajshekhar Karpoormath,S Radha,Shammi Kumar Singh,R Mutthukannan,Gahininath Y. Bharate,M. Vijayan +6 more
TL;DR: In this article, the most common protection method used is the application of a co-operative combinatorial approach to prevent corrosion in metal and their alloys and to avoid structural damage and loss of functionality.
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Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene–maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia–reperfusion injury
Jun Fang,Takahiro Seki,Takahiro Seki,Takahiro Seki,Haibo Qin,Gahininath Y. Bharate,Arun K. Iyer,Arun K. Iyer,Hiroshi Maeda,Hiroshi Maeda +9 more
TL;DR: SMA-AHPP exerted a potent cytoprotective effect against I/R injury in rat liver, by inhibiting XO activity and the subsequent generation of O2 −, indicating the involvement of reactive oxygen species generated by XO.