G
Gaku Mizuguchi
Researcher at Johns Hopkins University
Publications - 25
Citations - 4582
Gaku Mizuguchi is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nucleosome & Histone code. The author has an hindex of 18, co-authored 25 publications receiving 4232 citations. Previous affiliations of Gaku Mizuguchi include National Institutes of Health & Kyoto University.
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Journal ArticleDOI
ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex
TL;DR: It is found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with hist one H2AZ in nucleosome arrays.
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A chromatin remodelling complex involved in transcription and DNA processing
TL;DR: Results indicate that chromatin remodelling driven by the Ino80 ATPase may be connected to transcription as well as DNA damage repair.
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Stepwise histone replacement by SWR1 requires dual activation with histone H2A.Z and canonical nucleosome.
TL;DR: It is shown that promoter-proximal nucleosomes are highly heterogeneous for H2A.Z in Saccharomyces cerevisiae, with substantial representation of nucleosome containing one, two, or zero H2a.Z molecules.
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Fast multicolor 3D imaging using aberration-corrected multifocus microscopy
Sara Abrahamsson,Sara Abrahamsson,Sara Abrahamsson,Jiji Chen,Bassam Hajj,Sjoerd Stallinga,Alexander Y. Katsov,Jan Wisniewski,Jan Wisniewski,Gaku Mizuguchi,Gaku Mizuguchi,Gaku Mizuguchi,Pierre Soule,Florian Mueller,Florian Mueller,Dugast Darzacq Claire,Dugast Darzacq Claire,Dugast Darzacq Claire,Xavier Darzacq,Xavier Darzacq,Carl Wu,Carl Wu,Carl Wu,Cornelia I. Bargmann,Cornelia I. Bargmann,David A. Agard,Maxime Dahan,Maxime Dahan,Maxime Dahan,Mats G. L. Gustafsson +29 more
TL;DR: An aberration-corrected multifocus microscopy method capable of producing an instant focal stack of nine 2D images that enables high-resolution 3D imaging in multiple colors with single-molecule sensitivity, at speeds limited by the camera readout time of a single image.
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Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomes.
TL;DR: Findings indicate that nonhistone Scm3 serves to assemble and maintain Cse4-H4 at centromeres and may replace histone H2A-H2B dimers in a centromere-specific nucleosome core.