G
Gary L. Wenk
Researcher at Ohio State University
Publications - 170
Citations - 16341
Gary L. Wenk is an academic researcher from Ohio State University. The author has contributed to research in topics: Basal forebrain & Neuroinflammation. The author has an hindex of 64, co-authored 170 publications receiving 15486 citations. Previous affiliations of Gary L. Wenk include Johns Hopkins University & University of Arizona.
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
Journal Article
Neuropathologic changes in Alzheimer's disease.
TL;DR: The nature and extent of the changes associated with neural systems, possible treatment approaches, and a potential mechanism involving chronic neuroinflammation to explain the pattern of neuropathologic changes in Alzheimer's disease are summarized.
Journal ArticleDOI
Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments
TL;DR: The results provide information about the behavioral functions of the basal forebrain cholinergic system and suggest that pathological changes in certain components of this system can cause disorders of memory.
Journal ArticleDOI
The Neuropharmacological Basis for the Use of Memantine in the Treatment of Alzheimer's Disease
Michael A. Rogawski,Gary L. Wenk +1 more
TL;DR: Channel-level factors may allow memantine to block channel activity induced by low, tonic levels of glutamate--an action that might contribute to symptomatic improvement and could theoretically protect against weak excitotoxicity--while sparing synaptic responses required for normal behavioral functioning, cognition and memory.
Journal ArticleDOI
Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice
Paul T. Jantzen,Karen E. Connor,Giovanni DiCarlo,Gary L. Wenk,John L. Wallace,Amyn M. Rojiani,Domenico Coppola,Dave Morgan,Marcia N. Gordon +8 more
TL;DR: NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Aβ deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.