D
David G. Walker
Researcher at Wesley Hospital
Publications - 99
Citations - 8155
David G. Walker is an academic researcher from Wesley Hospital. The author has contributed to research in topics: Glioma & Population. The author has an hindex of 32, co-authored 93 publications receiving 7466 citations. Previous affiliations of David G. Walker include Royal Melbourne Hospital & University of British Columbia.
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
Journal ArticleDOI
Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease
Scott D. Webster,Lih-Fen Lue,Libuse Brachova,Andrea J. Tenner,Patrick L. McGeer,Kazuhiro Terai,David G. Walker,B Bradt,Neil R. Cooper,Joseph Rogers +9 more
TL;DR: C5b-9 is abundantly present in Alzheimer's disease cortex, associated with neurofibrillary tangle containing neurons, dystrophic neurites within neuritic plaques, and neuropil threads, but is weakly detected, if at all, in nondemented elderly cortex under the same conditions.
Journal ArticleDOI
EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme
Bryan W. Day,Brett W. Stringer,Fares Al-Ejeh,Michael J. Ting,John W Wilson,Kathleen S. Ensbey,Paul R. Jamieson,Zara C. Bruce,Yi Chieh Lim,Carolin Offenhäuser,Sara Charmsaz,Leanne Cooper,Jennifer K Ellacott,Angus Harding,Lucie Leveque,Po Inglis,Po Inglis,Suzanne Allan,Suzanne Allan,David G. Walker,Martin Lackmann,Geoffrey W. Osborne,Kum Kum Khanna,Brent A. Reynolds,Jason D. Lickliter,Jason D. Lickliter,Andrew W. Boyd,Andrew W. Boyd +27 more
TL;DR: Results identify EphA3 as a functional, targetable receptor in GBM and appears critically involved in maintaining tumor cells in a less differentiated state by modulating mitogen-activated protein kinase signaling.
Journal ArticleDOI
Unmet supportive care needs and interest in services among patients with a brain tumour and their carers.
Monika Janda,Monika Janda,Suzanne K. Steginga,Suzanne K. Steginga,Jeff Dunn,Jeff Dunn,Jeff Dunn,Danette Langbecker,David G. Walker,Elizabeth G. Eakin +9 more
TL;DR: A cross-sectional survey was posted to 363 households who were subscribed to the Queensland Cancer Fund Brain Tumour Support Service in 2005 and 75 patients and 70 carers (response rate 29.8%) returned completed questionnaires as mentioned in this paper.
Journal ArticleDOI
Activation of Macrophages by Alzheimer β Amyloid Peptide
TL;DR: To investigate whether β amyloid peptide (βAP) may activate microglia, the effects of synthetic β AP and a subfragment on rat peritoneal macrophages were assessed using four different assays for activation.