Gary M. Fox

TL;DR: In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.

TL;DR: Three-dimensional structures of two members of the fibroblast growth factor (FGF) family of proteins, bovine acidic FGF and human basic FGF, have been crystallographically determined and the locations of sequences implicated in receptor and heparin binding by FGF are presented.

TL;DR: It is reported here that recombinant B61 induces autophosphorylation of ECK in intact cells, consistent with B61 being an authentic ligand for ECK.

TL;DR: The receptor for glial cell line-derived neurotrophic factor (GDNF) consists of GFRα-1 and Ret, and it is reported that neurturin can bind to either GFR α-1 or G FRα-2, a novel receptor related to GFRβ, suggesting that GFRs mediate the action of GDNF family ligands in vivo.

TL;DR: There are multiple mechanisms regulating the interaction between Ret and the α-receptors that mediates the effects of GDNF family trophic factors on the survival and differentiation of cells and on neuron–target interactions in the nervous system.