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Bruce W. Altrock
Researcher at Amgen
Publications - 9
Citations - 1849
Bruce W. Altrock is an academic researcher from Amgen. The author has contributed to research in topics: Amino acid & Antibody. The author has an hindex of 9, co-authored 9 publications receiving 1800 citations.
Papers
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Journal ArticleDOI
GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
TL;DR: In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.
Journal ArticleDOI
Role of platelet-derived growth factor in wound healing.
TL;DR: PDGF appears to transduce its signal through wound macrophages and may trigger the induction of positive autocrine feedback loops and synthesis of endogenous wound PDGF and other growth factors, thereby enhancing the cascade of tissue repair processes required for a fully‐healed wound.
Journal ArticleDOI
Control of misincorporation of de novo synthesized norleucine into recombinant interleukin-2 in E. coli.
Larry B. Tsai,Hsieng Sen Lu,William C. Kenney,Craig Curless,Michael L. Klein,Por-Hsiung Lai,Dennis Fenton,Bruce W. Altrock,Michael Benjamin Mann +8 more
TL;DR: Interleukin-2 produced from a recombinant E. coli was found to contain as much as 19% norleucine in place of methionine in a minimal medium fermentation, and medium supplementation experiments and use of a leucine-requiring mutant host strain indicated the origin of norleucaine to be de novo biosynthesis by reactions involving the enzymes of the leucin biosynthetic pathway.
Patent
Use of gm-csf and g-csf to promote accelerated wound healing
Glenn F. Pierce,Bruce W. Altrock +1 more
TL;DR: In this paper, a method utilizing GM-CSF and GCSF to promote accelerated wound healing in mammals is described, which comprises administering topically to the mammal a therapeutically effective amount of either of these two polypeptides.
Journal ArticleDOI
Structure and Activity of Glycosylated Human Interferon-γ
TL;DR: Structural properties and activity of recombinant human interferon-γ purified from Chinese hamster ovary cells or a natural source were determined and compared with those of natural sources.