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Gaurav Manohar Rajani
Researcher at MedImmune
Publications - 11
Citations - 755
Gaurav Manohar Rajani is an academic researcher from MedImmune. The author has contributed to research in topics: Adjuvant & Vaccination. The author has an hindex of 7, co-authored 10 publications receiving 547 citations. Previous affiliations of Gaurav Manohar Rajani include Penn State Milton S. Hershey Medical Center.
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Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
Paul A. Muller,Balázs Koscsó,Gaurav Manohar Rajani,Korey Stevanovic,Marie-Luise Berres,Daigo Hashimoto,Arthur Mortha,Marylene Leboeuf,Xiu-Min Li,Daniel Mucida,E. Richard Stanley,Stephanie Dahan,Kara Gross Margolis,Michael D. Gershon,Miriam Merad,Milena Bogunovic +15 more
TL;DR: This work demonstrates that, in the steady state, muscularis macrophages regulate peristaltic activity of the colon and identifies a plastic, microbiota-driven crosstalk between muscularis Macrophages and enteric neurons that controls gastrointestinal motility.
Journal ArticleDOI
Erratum: Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility (Cell (2014) 158 (300â€"313) )
Paul A. Muller,Balázs Koscsó,Gaurav Manohar Rajani,Korey Stevanovic,Marie-Luise Berres,Daigo Hashimoto,Arthur Mortha,Marylene Leboeuf,Xiu-Min Li,Daniel Mucida,E. Richard Stanley,Stephanie Dahan,Kara Gross Margolis,Michael D. Gershon,Miriam Merad,Milena Bogunovic +15 more
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Immunization with Low Doses of Recombinant Postfusion or Prefusion Respiratory Syncytial Virus F Primes for Vaccine-Enhanced Disease in the Cotton Rat Model Independently of the Presence of a Th1-Biasing (GLA-SE) or Th2-Biasing (Alum) Adjuvant.
Kirsten Schneider-Ohrum,Corinne Cayatte,Angie Snell Bennett,Gaurav Manohar Rajani,Patrick M. Mctamney,Krystal Nacel,Leigh Hostetler,Lily Cheng,Kuishu Ren,Terrence O'Day,Gregory A. Prince,Michael P. McCarthy +11 more
TL;DR: The findings presented here underscore the need to evaluate a nonlive RSV vaccine candidate during preclinical development over a wide dose range in the cotton rat RSV enhanced-disease model, as suboptimal dosing of several RSV F subunit vaccine candidates led to the priming for ERD.
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Impact of formulation and particle size on stability and immunogenicity of oil-in-water emulsion adjuvants
Vidyashankara Iyer,Corinne Cayatte,Bernardo Guzman,Kirsten Schneider-Ohrum,Ryan Matuszak,Angie Snell,Gaurav Manohar Rajani,Michael P. McCarthy,Bilikallahalli K. Muralidhara +8 more
TL;DR: In vivo studies using the emulsions as an adjuvant with RSV F antigen revealed that superior immunogenicity could be achieved with the 80 nm particle size emulsion.
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PCPP-Adjuvanted Respiratory Syncytial Virus (RSV) sF Subunit Vaccine: Self-Assembled Supramolecular Complexes Enable Enhanced Immunogenicity and Protection.
Corinne Cayatte,Alexander Marin,Gaurav Manohar Rajani,Kirsten Schneider-Ohrum,Angie Snell Bennett,Jason D. Marshall,Alexander K. Andrianov +6 more
TL;DR: It is demonstrated that RSV sF-PCPP formulations induce high neutralization titers to RSV comparable to alum formulations even at a low PCPP dose and protect animals against viral challenge both in the lung and in the upper respiratory tract.