G
Gaurav Swarnkar
Researcher at Washington University in St. Louis
Publications - 43
Citations - 1197
Gaurav Swarnkar is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Osteoclast & Bone remodeling. The author has an hindex of 20, co-authored 40 publications receiving 915 citations. Previous affiliations of Gaurav Swarnkar include Council of Scientific and Industrial Research & Central Drug Research Institute.
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Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats.
Ritu Trivedi,Sudhir Kumar,Avinash Kumar,Jawed A. Siddiqui,Gaurav Swarnkar,Varsha Gupta,Amruta Kendurker,Anil Kumar Dwivedi,Jose R. Romero,Naibedya Chattopadhyay +9 more
TL;DR: It is shown that K is non-estrogenic in vivo and exerts bone anabolic activity with attendant inhibition of bone marrow adipogenesis, and exhibits no estrogenicity at the uterine level.
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LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Manoj Arra,Gaurav Swarnkar,Ke Ke,Jesse E. Otero,Jun Ying,Xin Duan,Takashi Maruyama,Muhammad Farooq Rai,Regis J. O'Keefe,Gabriel Mbalaviele,Jie Shen,Yousef Abu-Amer,Yousef Abu-Amer +12 more
TL;DR: It is shown that inflammatory NF-κB signalling drives a glycolytic shift in chondrocytes and the production of ROS, which drives cartilage catabolism, which identifies LDHA as a potential therapeutic target for OA treatment.
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A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: The role of aryl hydrocarbon receptor as a mediator of osteogenic action
Kunal Sharan,Jay S. Mishra,Gaurav Swarnkar,Jawed A. Siddiqui,Kainat Khan,Rashmi Kumari,Preeti Rawat,Rakesh Maurya,Sabyasachi Sanyal,Naibedya Chattopadhyay +9 more
TL;DR: The data suggest that GTDF stimulates osteoblast growth and differentiation via the AhR and promotes modeling‐directed bone accrual, accelerates bone healing after injury, and exerts anabolic effects on osteopenic rats likely by a direct stimulatory effect on osteoprogenitors.
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Co-expression of Arabidopsis transcription factor, AtMYB12, and soybean isoflavone synthase, GmIFS1, genes in tobacco leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotective activity.
Ashutosh Pandey,Prashant Misra,Mohd Parvez Khan,Gaurav Swarnkar,Mahesh Chandra Tewari,Sweta Bhambhani,Ritu Trivedi,Naibedya Chattopadhyay,Prabodh Kumar Trivedi +8 more
TL;DR: The results establish an efficient strategy for successful pathway engineering of isoflavones and other flavonoids in crop plants and provide a direct evidence of improved osteoprotective effect of transgenic plant extract.
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Role of Phytochemicals in the Prevention of Menopausal Bone Loss: Evidence from In Vitro and In Vivo, Human Interventional and Pharmacokinetic Studies
TL;DR: Making analogues of the most potent molecule for developing synthetic series with rational drug design approach could pay rich dividends in menopausal osteoporosis therapy.