G
Gavin W. Sewell
Researcher at University College London
Publications - 26
Citations - 1228
Gavin W. Sewell is an academic researcher from University College London. The author has contributed to research in topics: Inflammation & Tumor necrosis factor alpha. The author has an hindex of 14, co-authored 24 publications receiving 1089 citations.
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Journal ArticleDOI
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
Andrew M. Smith,Farooq Rahman,Bu’Hussain Hayee,Simon J Graham,Daniel Marks,Gavin W. Sewell,Christine D. Palmer,Jonathan I. Wilde,Brian M. J. Foxwell,Israel S. Gloger,Trevor J. Sweeting,Mark Marsh,Ann P. Walker,Stuart Bloom,Anthony W. Segal +14 more
TL;DR: It is suggested that in CD macrophages, an abnormal proportion of cytokines are routed to lysosomes and degraded rather than being released through the normal secretory pathway, which indicates accelerated intracellular breakdown.
Journal ArticleDOI
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
Alastair O'Brien,James N. Fullerton,Karen A. Massey,Grace Auld,Gavin W. Sewell,Sarah James,Justine Newson,Effie Karra,Alison Winstanley,William Alazawi,Rita García-Martínez,Joan Cordoba,Anna Nicolaou,Derek W. Gilroy +13 more
TL;DR: Treatment with COX inhibitors or albumin restored immune competence and survival following infection with group B Streptococcus and taken together, human albumin solution infusions may be used to reduce circulating PGE2 levels, attenuating immune suppression and reducing the risk of infection in patients with acutely decompensated cirrhosis or ESLD.
Journal ArticleDOI
Crohn’s Disease: an Immune Deficiency State
TL;DR: A substantial body of data has emerged in recent years to suggest that the primary defect in Crohn’s disease is actually one of relative immunodeficiency, and the evidence for such a phenomenon is considered in contrast to alternative prevailing hypotheses and some of the potential paradoxes that it generates.
Journal ArticleDOI
The immunopathogenesis of Crohn's disease: a three-stage model.
TL;DR: Patients with Crohn's disease almost without exception exhibit a gross phenotype, namely a profound systemic failure of the acute inflammatory response, leading to local chronic granulomatous inflammation and compensatory adaptive immunological changes, as well as constitutional symptoms.
Journal ArticleDOI
G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction
Bu’Hussain Hayee,Aristotelis Antonopoulos,Emma J. Murphy,Farooq Rahman,Gavin W. Sewell,Bradley N. Smith,Sara McCartney,Mark Furman,Georgina W. Hall,Stuart Bloom,Stuart M. Haslam,Howard R. Morris,Kaan Boztug,Kaan Boztug,Christoph Klein,Bryan Winchester,Edgar Pick,David C. Linch,Rosemary E. Gale,Andrew M. Smith,Anne Dell,Anthony W. Segal +21 more
TL;DR: The neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of patients with G6PC3 and G6PT syndromes is studied to better understand the causes of neutrophils dysfunction and merit designation of both Syndromes as a new class of congenital disorders of glycosylation.