Gavin W. Sewell

TL;DR: It is suggested that in CD macrophages, an abnormal proportion of cytokines are routed to lysosomes and degraded rather than being released through the normal secretory pathway, which indicates accelerated intracellular breakdown.

TL;DR: Treatment with COX inhibitors or albumin restored immune competence and survival following infection with group B Streptococcus and taken together, human albumin solution infusions may be used to reduce circulating PGE2 levels, attenuating immune suppression and reducing the risk of infection in patients with acutely decompensated cirrhosis or ESLD.

TL;DR: A substantial body of data has emerged in recent years to suggest that the primary defect in Crohn’s disease is actually one of relative immunodeficiency, and the evidence for such a phenomenon is considered in contrast to alternative prevailing hypotheses and some of the potential paradoxes that it generates.

TL;DR: Patients with Crohn's disease almost without exception exhibit a gross phenotype, namely a profound systemic failure of the acute inflammatory response, leading to local chronic granulomatous inflammation and compensatory adaptive immunological changes, as well as constitutional symptoms.

TL;DR: The neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of patients with G6PC3 and G6PT syndromes is studied to better understand the causes of neutrophils dysfunction and merit designation of both Syndromes as a new class of congenital disorders of glycosylation.