Geoffrey C. Gurtner

TL;DR: A predictive model for delayed wound healing that uses information collected during routine care in outpatient wound care centers to predict delayed healing wounds is developed and can improve patient care by allowing clinicians to increase the aggressiveness of intervention in patients most at risk.

TL;DR: A novel method combining microfluidic-based single cell analysis and information theory to characterize and predict transcriptional programs across hundreds of individual cells is developed and demonstrated that multiple subpopulations exist within a well-studied and putatively homogeneous stem cell population, murine long-term hematopoietic stem cells (LT-HSCs).

TL;DR: Although adipose-derived stromal cell survival in the hypoxic graft environment decreases significantly over time, these cells provide multiple angiogenic growth factors, which may be attributable to improved graft vascularization.

TL;DR: Results suggest that mechanical strain up-regulates matrix remodeling genes and down-regulate normal cellular apoptosis, resulting in more cells, each of which produces more matrix, which may underlie the pathophysiology of hypertrophic scars and other fibrotic processes in vivo.

TL;DR: The findings suggest that PEG-HA-RGD-based hydrogel provides an effective niche capable of augmenting the regenerative potential of ASCs and promoting burn wound healing.