G
Geoffrey Keir
Researcher at University College London
Publications - 85
Citations - 6188
Geoffrey Keir is an academic researcher from University College London. The author has contributed to research in topics: Multiple sclerosis & Cerebrospinal fluid. The author has an hindex of 41, co-authored 85 publications receiving 5829 citations. Previous affiliations of Geoffrey Keir include UCL Institute of Neurology & University of London.
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Journal ArticleDOI
Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report.
Magnus Andersson,José C. Álvarez-Cermeño,Giorgio Bernardi,I. Cogato,Pam Fredman,Jette L. Frederiksen,Sten Fredrikson,Paolo Gallo,Lm. Grimaldi,M. Grønning,Geoffrey Keir,K.J.B. Lamers,Hans Link,A. Magalhaes,Ar. Massaro,Sten Öhman,Hansotto Reiber,Lars Rönnbäck,M. Schluep,E. Schuller,Christian Sindic,E J Thompson,Maria Trojano,U. Wurster +23 more
TL;DR: Measurement of the combined local synthesis of antibodies against measles, rubella, and/or varicella zoster could represent a significant advance if it offers higher specificity (not sensitivity) for identifying chronic rather than acute inflammation.
Cerebrospinal fluid inthediagnosis ofmultiple sclerosis: a consensus report
Geoffrey Keir,M Andersson,Giorgio Bernardi,S Fredrikson,K.J.B. Lamers,Hansotto Reiber,M. Schluep,C J M Sindic,Maria Trojano,U Wurster +9 more
TL;DR: The most sensitive method for detection of oligoclonal immunoglobulin bands isisoelectric focusing as discussed by the authors, where the same amounts ofIgG in parallel CSF and serum samples are used to reveal the IgG specific antibody staining.
Journal ArticleDOI
Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis: A Consensus Statement
Mark S. Freedman,Edward J. Thompson,Florian Deisenhammer,Gavin Giovannoni,Guy Grimsley,Geoffrey Keir,Sten Öhman,Michael K. Racke,Mohammad K. Sharief,Christian Sindic,Finn Sellebjerg,Wallace W. Tourtellotte +11 more
TL;DR: In this article, the authors proposed new criteria for the diagnosis of multiple sclerosis (MS) using both clinical and paraclinical criteria, the latter involving information obtained from magnetic resonance imaging, evoked potentials, and cerebrospinal fluid (CSF) analysis.
Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis
Mark S. Freedman,Edward J. Thompson,Florian Deisenhammer,Gavin Giovannoni,Guy Grimsley,Geoffrey Keir,Sten Öhman,Michael K. Racke,Mohammad K. Sharief,Christian Sindic,Finn Sellebjerg,Wallace W. Tourtellotte +11 more
TL;DR: Recommendations for establishing a standard for the evaluation of CSF in patients suspected of having MS should greatly complement the new criteria in ensuring that a correct diagnosis of MS is being made.
Journal ArticleDOI
Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations
Axel Petzold,M.J. Eikelenboom,Djordje Gveric,Geoffrey Keir,Miles D. Chapman,R.H.C. Lazeron,R.H.C. Lazeron,M. L. Cuzner,Chris H. Polman,B. M. J. Uitdehaag,E. J. Thompson,Gavin Giovannoni +11 more
TL;DR: It is found that S100B is a good marker for the relapsing phase of the disease as opposed to ferritin, which is elevated throughout the entire course, and GFAP correlated with disability scales and may therefore be a marker for irreversible damage.