G
Geoffrey M. Cooper
Researcher at Boston University
Publications - 174
Citations - 20081
Geoffrey M. Cooper is an academic researcher from Boston University. The author has contributed to research in topics: Gene & Transfection. The author has an hindex of 56, co-authored 174 publications receiving 19698 citations. Previous affiliations of Geoffrey M. Cooper include Harvard University & University of Washington.
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Journal ArticleDOI
Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases
TL;DR: This report reports that the MDM2 oncoprotein is cleaved by members of the CPP32 subfamily of interleukin 1-β convertase proteases both in vitro and in vivo, resulting in the disappearance ofMDM2 from apoptotic cells.
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Molecular cloning and characterization of the chicken gene homologous to the transforming gene of Rous sarcoma virus.
TL;DR: Analysis of the cloned chicken src locus by restriction and heteroduplex mapping indicates that the locus contains 1.6-1.9 kb of DNA homologous to the viral src gene.
Journal ArticleDOI
Cellular transforming genes and oncogenesis.
Geoffrey M. Cooper,Mary-Ann Lane +1 more
TL;DR: Transforming genes of other lymphoid neoplasms ( i x l , ix-2 and i x -3) are identified and cellular transforming genes by transfection is identified.
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Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences.
TL;DR: Cl cloning sequences upstream of the truncated raf loci are shown to involve the fusion of three different 5' non-raf human sequences to the human raf gene, suggesting that 5' truncation alone may be sufficient to activate the transforming potential of cellular raf genes.
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Transfection by Exogenous and Endogenous Murine Retrovirus DNAs
TL;DR: DNA transfection is used to study the endogenous retrovirus genomes inherited by uninfected mouse cells to find out the infectivities of exogenously infected cells with ecotropic and xenotropic MuLVs.