G
Georgia Sotiropoulou
Researcher at RMIT University
Publications - 105
Citations - 4907
Georgia Sotiropoulou is an academic researcher from RMIT University. The author has contributed to research in topics: Kallikrein & Cancer. The author has an hindex of 38, co-authored 97 publications receiving 4589 citations. Previous affiliations of Georgia Sotiropoulou include Mount Sinai Hospital, Toronto & University of Patras.
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Journal ArticleDOI
A Potential Role for Multiple Tissue Kallikrein Serine Proteases in Epidermal Desquamation
Carla A. Borgoño,Iacovos P. Michael,Nahoko Komatsu,Arumugam Jayakumar,Ravi Kapadia,Gary L. Clayman,Georgia Sotiropoulou,Eleftherios P. Diamandis +7 more
TL;DR: It is indicated that multiple KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI and these findings may have clinical implications for the treatment of skin disorders in which KLK activity is elevated.
Journal ArticleDOI
A novel protease homolog differentially expressed in breast and ovarian cancer.
Anthony Anisowicz,Georgia Sotiropoulou,Georgia Sotiropoulou,Göran Stenman,Samuel C. Mok,Ruth Sager +5 more
TL;DR: Protease M expression (mRNA) may be a useful marker in the detection of primary mammary carcinomas, as well as primary ovarian cancers, and other medical applications are also likely, based on sequence relatedness to trypsin and PSA.
Journal ArticleDOI
Functional roles of human kallikrein-related peptidases.
Georgia Sotiropoulou,Georgios Pampalakis,Eleftherios P. Diamandis,Eleftherios P. Diamandis,Eleftherios P. Diamandis +4 more
TL;DR: Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles and represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies.
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Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation.
Roberto Lin,Yoshihiko Nagai,Robert Sladek,Yolande Bastien,Joanne Ho,Kevin Petrecca,Georgia Sotiropoulou,Eleftherios P. Diamandis,Thomas J. Hudson,John H. White +9 more
TL;DR: The data indicate that EB1089 performs three key functions of a cancer chemoprevention agent; it is antiproliferative, it induces cellular differentiation, and has potential genoprotective effects.
Journal ArticleDOI
Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate.
Eva Pipili-Synetos,Athanasios A. Papageorgiou,Eleni Sakkoula,Georgia Sotiropoulou,Georgia Sotiropoulou,Theodore Fotsis,Theodore Fotsis,George Karakiulakis,George Karakiulakis,M.E. Maragoudakis,M.E. Maragoudakis +10 more
TL;DR: The results indicate that ISMN and ISDN inhibit angiogenesis and tumour growth and metastasis in an animal tumour model, and it is considered that these nitrovasodilators which are widely used therapeutically and have well characterized pharmacological profiles, may also possess antitumour properties in the clinic.