G
Gérard Gradwohl
Researcher at French Institute of Health and Medical Research
Publications - 59
Citations - 10157
Gérard Gradwohl is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Enteroendocrine cell & Pancreas. The author has an hindex of 37, co-authored 57 publications receiving 9657 citations. Previous affiliations of Gérard Gradwohl include Centre national de la recherche scientifique.
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Journal ArticleDOI
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
TL;DR: Ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types, and it is shown that ngn3-positive cells coexpress neither insulin nor glucagon, suggesting thatngn3 marks early precursors of pancreaticendocrine cells.
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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
Daniel J. Dumont,Gérard Gradwohl,Guo-Hua Fong,Mira C. Puri,Marina Gertsenstein,A. Auerbach,Martin L. Breitman +6 more
TL;DR: Observations demonstrate that the Tek signaling pathway plays a critical role in the differentiation, proliferation, and survival of endothelial cells in the mouse embryo.
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Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development
Daniel J. Dumont,Guo-Hua Fong,Mira C. Puri,Mira C. Puri,Gérard Gradwohl,Kari Alitalo,Martin L. Breitman,Martin L. Breitman +7 more
TL;DR: A possible dual role for VEGF which includes a chemotactic and/or a cellular maintenance role forVEGF during vascularization of the mouse embryo is suggested.
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Opposing actions of Arx and Pax4 in endocrine pancreas development
Patrick Collombat,Ahmed Mansouri,Jacob Hecksher-Sørensen,Palle Serup,Jens Krull,Gérard Gradwohl,Peter Gruss +6 more
TL;DR: It is proposed that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts.
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The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons
Carol Fode,Gérard Gradwohl,Xavier Morin,Andrée Dierich,Marianne LeMeur,Christo Goridis,François Guillemot +6 more
TL;DR: Interestingly, the homeobox gene Phox2a is activated independently of ngn2 in epibranchial placodes, suggesting that neuronal fate and neuronal subtype identity may be specified independently in cranial sensory ganglia.