G
Gérard Gradwohl
Researcher at French Institute of Health and Medical Research
Publications - 59
Citations - 10157
Gérard Gradwohl is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Enteroendocrine cell & Pancreas. The author has an hindex of 37, co-authored 57 publications receiving 9657 citations. Previous affiliations of Gérard Gradwohl include Centre national de la recherche scientifique.
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Journal ArticleDOI
Neurogenesis in hippocampal slice cultures.
TL;DR: The hippocampal slice culture is established as a promising ex vivo model for investigating neurogenesis under controlled conditions and the regional distribution of newly born neurons closely resembled that observed in vivo in the adult hippocampus.
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Characterization of the proneural gene regulatory network during mouse telencephalon development
Julia M. Gohlke,Olivier Armant,Olivier Armant,Frederick M. Parham,Marjolein V. Smith,Céline Zimmer,Diogo S. Castro,Laurent Nguyen,Joel S. Parker,Gérard Gradwohl,Christopher J. Portier,François Guillemot +11 more
TL;DR: Together, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation.
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Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells
Julie Piccand,Perrine Strasser,David J. Hodson,Aline Meunier,Tao Ye,Céline Keime,Marie-Christine Birling,Guy A. Rutter,Gérard Gradwohl +8 more
TL;DR: It is shown that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally mature β cells in mice, and raises the possibility that changes in RFX6 expression or activity may contribute to β cell failure in humans.
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Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
Georg Mellitzer,Anthony Beucher,Viviane Lobstein,Pascal Michel,Sylvie Robine,Michèle Kedinger,Gérard Gradwohl +6 more
TL;DR: Data from mice generated with intestinal-specific ablation of the proendocrine transcription factor neurogenin 3 help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium.
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Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus
Michelle Pelling,Neal Anthwal,David E. G. McNay,Gérard Gradwohl,Andrew B. Leiter,François Guillemot,Siew-Lan Ang +6 more
TL;DR: It is demonstrated that Ngn3+ progenitors contribute to subsets of POMC, NPY, TH and SF1 neurons and is required for the specification of these neuronal subtypes in the ventral hypothalamus.