G
Gianpiero Di Leva
Researcher at University of Salford
Publications - 49
Citations - 9521
Gianpiero Di Leva is an academic researcher from University of Salford. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 30, co-authored 44 publications receiving 8592 citations. Previous affiliations of Gianpiero Di Leva include Ohio State University & University of Modena and Reggio Emilia.
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Journal ArticleDOI
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
George A. Calin,Manuela Ferracin,Manuela Ferracin,Amelia Cimmino,Gianpiero Di Leva,Masayoshi Shimizu,Sylwia E. Wojcik,Marilena V. Iorio,Rosa Visone,Nurettin Ilfer Sever,Muller Fabbri,Muller Fabbri,Rodolfo Iuliano,Tiziana Palumbo,Flavia Pichiorri,Claudia Roldo,Ramiro Garzon,Cinzia Sevignani,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +24 more
TL;DR: A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.
Journal ArticleDOI
MicroRNAs in cancer.
TL;DR: In this paper, the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies are discussed.
Journal ArticleDOI
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.
Michela Garofalo,Gianpiero Di Leva,Giulia Romano,Gerard J. Nuovo,Sung-Suk Suh,Apollinaire Ngankeu,Cristian Taccioli,Flavia Pichiorri,Hansjuerg Alder,Paola Secchiero,Pierluigi Gasparini,Arianna Gonelli,Stefan Costinean,Mario Acunzo,Gerolama Condorelli,Carlo M. Croce +15 more
TL;DR: It is reported that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells, and it is demonstrated that the MET oncogene is involved in miR+222 activation through the c-Jun transcription factor.
Journal ArticleDOI
Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development
Flavia Pichiorri,Flavia Pichiorri,Sung Suk Suh,Sung Suk Suh,Alberto Rocci,Luciana De Luca,Cristian Taccioli,Cristian Taccioli,Ramasamy Santhanam,Wenchao Zhou,Don M. Benson,Craig Hofmainster,Hansjuerg Alder,Michela Garofalo,Gianpiero Di Leva,Stefano Volinia,Stefano Volinia,Huey Jen Lin,Danilo Perrotti,Michael Kuehl,Rami I. Aqeilan,Rami I. Aqeilan,Antonio Palumbo,Carlo M. Croce +23 more
TL;DR: Evidence is provided that miR-192, 194, and 215, which are downregulated in a subset of newly diagnosed MMs, can be transcriptionally activated by p53 and then modulate MDM2 expression, and that their downregulation plays a key role in MM development.
Journal ArticleDOI
miRNA profiling of cancer
Gianpiero Di Leva,Carlo M. Croce +1 more
TL;DR: How microRNA profiles are altered in cancer is discussed, highlighting their potential as sensitive biomarkers for cancer risk stratification, outcome prediction and classification of histological subtypes.