Gerry Steele

TL;DR: In this paper, a multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture.

TL;DR: In this article, a continuous oscillatory baffled crystallizer (COBC) was used for the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous ODE.

TL;DR: By applying the automated direct nucleation control (ADNC) approach problems with agglomeration and solvent inclusion were resolved and the ADNC approach was able to produce larger and more uniform crystals and also removed the residual solvent trapped between the crystals compared to the typical crystallization operation using linear cooling profile.

TL;DR: In this article, the results of the crystallization experiments and offline analysis were compared and interpreted using the information on the crystal structures of the three OABA polymorphs from the Cambridge Crystallographic database.

TL;DR: In this paper, the use of process analytical technology (PAT) tools, including focused beam reflectance measurement (FBRM) probe, turbidity meter, and attenuated total reflectance (ATR) UV−vis spectroscopy, for the monitoring and detection of polymorphic transformation during the antisolvent crystallization of sodium benzoate from a propan-2-ol (IPA)/water mixture was presented.