Journal ArticleDOI
Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
Levente L. Simon,Hajnalka Pataki,György Marosi,Fabian Meemken,Konrad Hungerbühler,Alfons Baiker,Srinivas Tummala,Brian Glennon,Martin Kuentz,Gerry Steele,Herman J. M. Kramer,James W. Rydzak,Zeng-Ping Chen,Julian Morris,Francois Kjell,Ravendra Singh,Rafiqul Gani,Krist V. Gernaey,Marjatta Louhi-Kultanen,John Oreilly,Niklas Sandler,Osmo Antikainen,Jouko Yliruusi,Patrick Frohberg,Joachim Ulrich,Richard D. Braatz,Tom Leyssens,Moritz von Stosch,Rui Oliveira,Reginald B. H. Tan,Huiquan Wu,Mansoor A. Khan,Des O'grady,Anjan Pandey,Remko Westra,Emmanuel Delle-Case,Detlef Pape,Daniele Angelosante,Yannick Maret,Olivier Steiger,Miklos Lenner,Kaoutar Abbou-Oucherif,Zoltan K. Nagy,James D. Litster,Vamsi Krishna Kamaraju,Min-Sen Chiu +45 more
TLDR
In this paper, a multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture.About:
This article is published in Organic Process Research & Development.The article was published on 2015-01-08. It has received 318 citations till now.read more
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Journal ArticleDOI
The Future of Pharmaceutical Manufacturing Sciences.
Jukka Rantanen,Johannes Khinast +1 more
TL;DR: This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques and addressing future manufacturing solutions, covering continuous processing and hot‐melt processing and printing‐based technologies.
Journal ArticleDOI
Continuous manufacturing – the Green Chemistry promise?
Luke Rogers,Klavs F. Jensen +1 more
TL;DR: In this article, a review of Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes is presented, where the principle of prevention greatly overshadows all other principles.
Journal ArticleDOI
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Ben J. Boyd,Christel A. S. Bergström,Zahari Vinarov,Martin Kuentz,Joachim Brouwers,Patrick Augustijns,Martin Brandl,Andreas Bernkop-Schnürch,Neha Shrestha,Véronique Préat,Anette Müllertz,Annette Bauer-Brandl,Vincent Jannin +12 more
TL;DR: The challenge presented by these drugs is defined, contemporary strategies to solve this challenge are outlined, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs are proposed.
Journal ArticleDOI
A Megatrend Challenging Analytical Chemistry: Biosensor and Chemosensor Concepts Ready for the Internet of Things.
Michael Mayer,Antje J. Baeumner +1 more
TL;DR: This review critically review those biosensor and chemosensor technologies and concepts used in an IoT setting or considered IoT-ready that were published in the period 2013-2018, while also pointing to those foundational concepts and ideas that arose over the last two decades.
Journal ArticleDOI
Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization
Thomas McGlone,Naomi E. B. Briggs,Catriona A. Clark,Cameron J. Brown,Jan Sefcik,Alastair J. Florence +5 more
TL;DR: Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state as discussed by the authors, which is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs).
References
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Journal ArticleDOI
Survey over image thresholding techniques and quantitative performance evaluation
Mehmet Sezgin,Bulent Sankur +1 more
TL;DR: 40 selected thresholding methods from various categories are compared in the context of nondestructive testing applications as well as for document images, and the thresholding algorithms that perform uniformly better over nonde- structive testing and document image applications are identified.
Journal ArticleDOI
Photometric Method For Determining Surface Orientation From Multiple Images
TL;DR: In this paper, a novel technique called photometric stereo is introduced, which is to vary the direction of incident illumination between successive images, while holding the viewing direction constant, and it is shown that this provides sufficient information to determine surface orientation at each image point.
Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TL;DR: This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.
Journal ArticleDOI
Pharmaceutical quality by design: product and process development, understanding, and control.
TL;DR: Implementation of QbD will enable transformation of the chemistry, manufacturing, and controls (CMC) review of abbreviated new drug applications into a science-based pharmaceutical quality assessment.