G
Giacomo De Luca
Researcher at Vita-Salute San Raffaele University
Publications - 122
Citations - 3913
Giacomo De Luca is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 19, co-authored 81 publications receiving 2318 citations. Previous affiliations of Giacomo De Luca include The Catholic University of America & Catholic University of the Sacred Heart.
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Journal ArticleDOI
Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study.
Giulio Cavalli,Giacomo De Luca,Corrado Campochiaro,Emanuel Della-Torre,Marco Ripa,Diana Canetti,Chiara Oltolini,Barbara Castiglioni,Chiara Tassan Din,Nicola Boffini,Alessandro Tomelleri,Nicola Farina,Annalisa Ruggeri,Patrizia Rovere-Querini,Giuseppe Di Lucca,S. Martinenghi,Raffaella Scotti,Moreno Tresoldi,Fabio Ciceri,Giovanni Landoni,Alberto Zangrillo,Paolo Scarpellini,Lorenzo Dagna +22 more
TL;DR: In this retrospective cohort study of patients with COVID-19 and ARDS managed with non-invasive ventilation outside of the ICU, treatment with high-dose anakinra was safe and associated with clinical improvement in 72% of patients.
Journal ArticleDOI
Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study.
Corrado Campochiaro,Emanuel Della-Torre,Giulio Cavalli,Giacomo De Luca,Marco Ripa,Nicola Boffini,Alessandro Tomelleri,Elena Baldissera,Patrizia Rovere-Querini,Annalisa Ruggeri,Giacomo Monti,Francesco De Cobelli,Alberto Zangrillo,Moreno Tresoldi,Antonella Castagna,Lorenzo Dagna +15 more
TL;DR: Clinical improvement and mortality were not statistically significant different between tocilizumab and standard treatment patients in this retrospective study on severe COVID-19 patients with hyper-inflammatory features.
Journal ArticleDOI
Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors.
Marco Ripa,Laura Galli,Andrea Poli,Chiara Oltolini,Vincenzo Spagnuolo,Andrea Mastrangelo,Camilla Muccini,Giacomo Monti,Giacomo De Luca,Giovanni Landoni,Lorenzo Dagna,Massimo Clementi,Patrizia Rovere Querini,Fabio Ciceri,Moreno Tresoldi,Adriano Lazzarin,Alberto Zangrillo,Paolo Scarpellini,Antonella Castagna,Andrea Andolina,Martina Baiardo Redaelli,Giorgia Bigai,Alba Bigoloni,Giorgia Borio,Simona Bossolasco,Elena Bruzzesi,Maria Grazia Calabrò,Stefania Calvisi,Corrado Campochiaro,Diana Canetti,Valentina Canti,Jacopo Castellani,Barbara Castiglioni,Giulio Cavalli,Ludovica Cavallo,Massimo Cernuschi,Matteo Chiurlo,Marta Cilla,Elena Cinel,Paola Cinque,Caterina Conte,Valentina Da Prat,Anna Danise,Rebecca De Lorenzo,Antonio Dell'Acqua,Raffaele Dell’Acqua,Emanuel Della Torre,Liviana Della Torre,Gaetano Di Terlizzi,Iulia Dumea,Federica Farolfi,Marica Ferrante,Claudia Frangi,Luca Fumagalli,Gabriele Gallina,Bruno Germinario,Nicola Gianotti,Monica Guffanti,Hamid Hasson,Francesca Lalla,Marco Lanzillotta,Raffaele Li Voti,Emanuela Messina,Chiara Molinari,Elena Moizo,Marco Montagna,Giulia Morsica,Silvia Nozza,Maria Pascali,Alessandro Patrizi,Marina Pieri,Antonella Poloniato,Dario Prestifilippo,Giuseppe A. Ramirez,Martina Ranzenigo,Jacopo Sapienza,Federico Seghi,Giuseppe Tambussi,Chiara Tassan Din,Stefano Turi,Caterina Uberti-Foppa,Concetta Vinci +81 more
TL;DR: Patients hospitalized with COVID-19 had a high incidence of secondary infections and early need for ICU, respiratory failure, and severe lymphopenia, were identified as risk factors for secondary infections.
Journal ArticleDOI
Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study.
Emanuel Della-Torre,Corrado Campochiaro,Giulio Cavalli,Giacomo De Luca,Angela Napolitano,Salvatore La Marca,Nicola Boffini,Valentina Da Prat,Gaetano Di Terlizzi,Marco Lanzillotta,Patrizia Rovere Querini,Annalisa Ruggeri,Giovanni Landoni,Moreno Tresoldi,Fabio Ciceri,Alberto Zangrillo,Francesco De Cobelli,Lorenzo Dagna +17 more
TL;DR: Overall clinical improvement and mortality in patients with severe COVID-19 pneumonia were not significantly different between sarilumab and standard of care and Sariluab was associated with faster recovery in a subset of patients showing minor lung consolidation at baseline.
Journal ArticleDOI
Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial.
François-Xavier Lescure,Hitoshi Honda,Robert A. Fowler,Jennifer Sloane Lazar,Genming Shi,Peter Wung,Naimish Patel,Owen Hagino,Ignacio J. Bazzalo,Marcelo M. Casas,Sebastián A. Nuñez,Yael Pere,Carlos M. Ibarrola,Marco A. Solis Aramayo,Maria C. Cuesta,Andrea E. Duarte,Pablo M. Gutierrez Fernandez,Maria A. Iannantuono,Erica A. Miyazaki,Javier P. Silvio,Dario G. Scublinsky,Alessandra Bales,Daniela Catarino,Elie Fiss,Sara Mohrbacher,Victor Sato,Antonio Baylao,Adilson Joaquim Westheimer Cavalcante,Francini Correa,Celso A. de Andrade,Juvencio José Duailibe Furtado,Nelson Ribeiro Filho,Valeria Telles,Leopoldo T. Trevelin,Ricardo Vipich,Rodrigo Boldo,Paula Borges,Suzana Margareth Lobo,Graziela Luckemeyer,Luana Machado,Maysa B. Alves,Ana Caroline Iglessias,Marianna M. Lago,Daniel Wagner de Castro Lima Santos,Hugo Chapdelaine,Emilia L. Falcone,Rahima Jamal,Me-Linh Luong,Madeleine Durand,Stephane Doucet,Francois-martin Carrier,Bryan Coburn,Lorenzo Del Sorbo,Sharon Walmsley,Sara Belga,Luke Y.C. Chen,Allison D. Mah,Theodore Steiner,Alissa J. Wright,J. Hajek,Neill K. J. Adhikari,Nick Daneman,Kosar Khwaja,Jason Shahin,Carolina Gonzalez,Rafael Silva,Marcelo Lindh,Gabriel Maluenda,Patricia Fernandez,Maite Oyonarte,Martin Lasso,Alexandre Boyer,Didier Bronnimann,Hoang-Nam Bui,Charles Cazanave,Helene Chaussade,Arnaud Desclaux,Mailys Ducours,Alexandre Duvignaud,Denis Malvy,Lisa J. Martin,Didier Neau,Duc Nguyen,Thierry Pistone,Gaetane Soubrane-Wirth,Julie Leitao,Clotilde Allavena,Charlotte Biron,Sabelline Bouchez,Benjamin Gaborit,Antoine Gregoire,Paul Le Turnier,Anne-Sophie Lecompte,Raphael Lecomte,Maeva Lefebvre,Francois Raffi,David Boutoille,Pascale H. Morineau,Romain Guéry,Emmanuel Chatelus,Nathalie Dumoussaud,Renaud Felten,Florina Luca,Bernard Goichot,Francis Schneider,Marie-Caroline Taquet,Matthieu Groh,Mathilde Roumier,Mathilde Neuville,Antoine Bachelard,Valentina Isernia,F-Xavier Lescure,Bao-Chau Phung,Anne Rachline,Aurelie Sautereau,Dorothee Vallois,Yves Bleher,Delphine Boucher,Clémentine Coudon,Jean Esnault,Thomas Guimard,Sophie Leautez-Nainville,Dominique Merrien,Marine Morrier,Pauline Motte-Vincent,Romain Gabeff,Hélène Leclerc,Céline Cozic,Romain Decours,Ronan Février,Gwenhael Colin,Sophie Abgrall,Dorothee Vignes,Raluca Sterpu,Mira Kuellmar,Melanie Meersch-Dini,Raphael Weiss,Alexander Zarbock,Christiane Antony,Marc M. Berger,Thorsten Brenner,Christian Taube,Frank Herbstreit,Sebastian Dolff,Margarethe Konik,Karsten Schmidt,Markus Zettler,Oliver Witzke,Boris Boell,Jorge Garcia Borrega,Philipp Koehler,Thomas Zander,Fabian Dusse,Othman Al-Sawaf,Philipp Köhler,Dennis A. Eichenauer,Matthias Kochanek,Alexander Shimabukuro-Vornhagen,Sibylle C. Mellinghoff,Annika Claßen,Jan-Michel Heger,Charlotte Meyer-Schwickerath,Paul Liedgens,Katrin Heindel,Ana Belkin,Asaf Biber,Mayan Gilboa,Itzchak Levy,Vladislav Litachevsky,Galia Rahav,Anat Finesod Wiedner,Tal Zilberman-Daniels,Yonatan Oster,Jacob Strahilevitz,Sigal Sviri,Elena Baldissera,Corrado Campochiaro,Giulio Cavalli,Lorenzo Dagna,Giacomo De Luca,Emanuel Della Torre,Alessandro Tomelleri,Davide Bernasconi De Luca,Amedeo F. Capetti,Massimo Coen,Maria V. Cossu,Massimo Galli,Andrea Giacomelli,Guido A. Gubertini,Stefano Rusconi,Giulia Burastero,Margherita Digaetano,Giovanni Guaraldi,Marianna Meschiari,Cristina Mussini,Cinzia Puzzolante,Sara Volpi,Marina Aiello,Alarico Ariani,Alfredo Chetta,Annalisa Frizzelli,Andrea Ticinesi,Domenico Tuttolomondo,Stefano Aliberti,Francesco Blasi,Marta F. Di Pasquale,Sofia Misuraca,Tommaso Pilocane,Edoardo Simonetta,Alessio M. Aghelmo,Claudio Angelini,Enrico Brunetta,Giorgio Walter Canonica,Michele Ciccarelli,Sara Dal Farra,Maria De Santis,Sebastian Ferri,Marco Folci,Giacomo Maria Guidelli,Enrico Heffler,Ferdinando Loiacono,Giacomo Malipiero,Giovanni Paoletti,Rosa Pedale,Francesca A. Puggioni,Francesca Racca,Aurora Zumbo,Morihiko Satou,Tatyana Lisun,Denis Protsenko,Nikolay Rubtsov,Irina Beloglazova,Daria Fomina,Mariana Lysenko,Sofia Serdotetskova,Vitali Firstov,Ivan Gordeev,Ilia Kokorin,Ksenia Komissarova,Nina Lapochkina,Elena Luchinkina,Valentin Malimon,Sevinch Mamedguseyinova,Ksenia Polubatonova,Natalia Suvorova,Jose R. Arribas,Alberto M. Borobia Perez,Fernando de la Calle Prieto,Juan Carlos Figueira,Rocio Motejano Sanchez,Marta Mora-Rillo,Concepcion Prados Sanchez,Javier Queiruga Parada,Francisco Fernandez Arnalich,Maria Guerro Barrientos,Alejandro Bendala Estrada,Aranzazu Caballero Marcos,Maria E. Garcia Leoni,Rita García-Martínez,Ana María Collado,Patricia Munoz Garcia,Ana Torres do Rego,Maria Garcia,Almudena Burrillo,Maricela Valerio Minero,Paloma Gijon Vidaurreta,Sonsoles Infante Herrero,Elena Velilla,Marina Machado,María Olmedo,Blanca Pinilla,Benito Almirante Gragera,Maria de la Esperanza Cañas Ruano,Sofia Contreras Medina,Alejandro Cortés Herrera,Vicenç Falcó Ferrer,Ricard Ferrer Roca,Xavier Nuvials Casals,Esteve Ribera Pascuet,Paula Suanzes Diez,Pedro Rebollo Castro,Felipe Garcia Alcaide,Alejandro Soriano,Aina Oliver Caldes,Ana González Cordón,Celia Cardozo,Lorena De la Mora Cañizo,Romina Pena López,Sandra Chamorro,Clara Crespillo-Andujar,Rosa Escudero Sanchez,Jesús Fortún-Abete,Begoña Monge-Maillo,Ana Moreno Zamora,Francesca Norman,Matilde Sanchez Conde,Sergio Serrano Villar,Pilar Vizcarra +297 more
TL;DR: In this article, the authors evaluated the safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical(requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.