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Enrico Heffler
Researcher at Humanitas University
Publications - 284
Citations - 6548
Enrico Heffler is an academic researcher from Humanitas University. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 35, co-authored 219 publications receiving 3927 citations. Previous affiliations of Enrico Heffler include University of Catania & University of Turin.
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Journal ArticleDOI
Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
Marek L. Kowalski,Ioana Agache,Sevim Bavbek,Arzu Bakirtas,Miguel Blanca,Grazyna Bochenek,Matteo Bonini,Enrico Heffler,Ludger Klimek,Tanya M. Laidlaw,Joaquim Mullol,Ewa Nizankowska-Mogilnicka,Hae-Sim Park,Marek Sanak,Mario Sánchez-Borges,Silvia Sanchez-Garcia,Glenis Scadding,Masami Taniguchi,María José Torres,Andrew A. White,Aleksandra Wardzyńska +20 more
TL;DR: Recommendations for the most effective management of a patient with N‐ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed.
Journal ArticleDOI
EUFOREA consensus on biologics for CRSwNP with or without asthma
Wytske Fokkens,Valerie J. Lund,Claus Bachert,Claus Bachert,Joaquim Mullol,Leif Bjermer,Jean Bousquet,Giorgio Walter Canonica,L Deneyer,Martin Desrosiers,Zuzana Diamant,Zuzana Diamant,Joseph K. Han,Enrico Heffler,Claire Hopkins,Roger Jankowski,Guy Joos,Andrew Knill,Jivianne T. Lee,Stella E. Lee,Gert Marien,Benoit Pugin,Brent A. Senior,Sven Seys,Peter Hellings +24 more
TL;DR: Novel therapies such as type 2 targeting biologics are emerging treatment options for patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely uncontrolled patients and may soon also become available for CRSwNP patients.
Journal ArticleDOI
Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial.
François-Xavier Lescure,Hitoshi Honda,Robert A. Fowler,Jennifer Sloane Lazar,Genming Shi,Peter Wung,Naimish Patel,Owen Hagino,Ignacio J. Bazzalo,Marcelo M. Casas,Sebastián A. Nuñez,Yael Pere,Carlos M. Ibarrola,Marco A. Solis Aramayo,Maria C. Cuesta,Andrea E. Duarte,Pablo M. Gutierrez Fernandez,Maria A. Iannantuono,Erica A. Miyazaki,Javier P. Silvio,Dario G. Scublinsky,Alessandra Bales,Daniela Catarino,Elie Fiss,Sara Mohrbacher,Victor Sato,Antonio Baylao,Adilson Joaquim Westheimer Cavalcante,Francini Correa,Celso A. de Andrade,Juvencio José Duailibe Furtado,Nelson Ribeiro Filho,Valeria Telles,Leopoldo T. Trevelin,Ricardo Vipich,Rodrigo Boldo,Paula Borges,Suzana Margareth Lobo,Graziela Luckemeyer,Luana Machado,Maysa B. Alves,Ana Caroline Iglessias,Marianna M. Lago,Daniel Wagner de Castro Lima Santos,Hugo Chapdelaine,Emilia L. Falcone,Rahima Jamal,Me-Linh Luong,Madeleine Durand,Stephane Doucet,Francois-martin Carrier,Bryan Coburn,Lorenzo Del Sorbo,Sharon Walmsley,Sara Belga,Luke Y.C. Chen,Allison D. Mah,Theodore Steiner,Alissa J. Wright,J. Hajek,Neill K. J. Adhikari,Nick Daneman,Kosar Khwaja,Jason Shahin,Carolina Gonzalez,Rafael Silva,Marcelo Lindh,Gabriel Maluenda,Patricia Fernandez,Maite Oyonarte,Martin Lasso,Alexandre Boyer,Didier Bronnimann,Hoang-Nam Bui,Charles Cazanave,Helene Chaussade,Arnaud Desclaux,Mailys Ducours,Alexandre Duvignaud,Denis Malvy,Lisa J. Martin,Didier Neau,Duc Nguyen,Thierry Pistone,Gaetane Soubrane-Wirth,Julie Leitao,Clotilde Allavena,Charlotte Biron,Sabelline Bouchez,Benjamin Gaborit,Antoine Gregoire,Paul Le Turnier,Anne-Sophie Lecompte,Raphael Lecomte,Maeva Lefebvre,Francois Raffi,David Boutoille,Pascale H. Morineau,Romain Guéry,Emmanuel Chatelus,Nathalie Dumoussaud,Renaud Felten,Florina Luca,Bernard Goichot,Francis Schneider,Marie-Caroline Taquet,Matthieu Groh,Mathilde Roumier,Mathilde Neuville,Antoine Bachelard,Valentina Isernia,F-Xavier Lescure,Bao-Chau Phung,Anne Rachline,Aurelie Sautereau,Dorothee Vallois,Yves Bleher,Delphine Boucher,Clémentine Coudon,Jean Esnault,Thomas Guimard,Sophie Leautez-Nainville,Dominique Merrien,Marine Morrier,Pauline Motte-Vincent,Romain Gabeff,Hélène Leclerc,Céline Cozic,Romain Decours,Ronan Février,Gwenhael Colin,Sophie Abgrall,Dorothee Vignes,Raluca Sterpu,Mira Kuellmar,Melanie Meersch-Dini,Raphael Weiss,Alexander Zarbock,Christiane Antony,Marc M. Berger,Thorsten Brenner,Christian Taube,Frank Herbstreit,Sebastian Dolff,Margarethe Konik,Karsten Schmidt,Markus Zettler,Oliver Witzke,Boris Boell,Jorge Garcia Borrega,Philipp Koehler,Thomas Zander,Fabian Dusse,Othman Al-Sawaf,Philipp Köhler,Dennis A. Eichenauer,Matthias Kochanek,Alexander Shimabukuro-Vornhagen,Sibylle C. Mellinghoff,Annika Claßen,Jan-Michel Heger,Charlotte Meyer-Schwickerath,Paul Liedgens,Katrin Heindel,Ana Belkin,Asaf Biber,Mayan Gilboa,Itzchak Levy,Vladislav Litachevsky,Galia Rahav,Anat Finesod Wiedner,Tal Zilberman-Daniels,Yonatan Oster,Jacob Strahilevitz,Sigal Sviri,Elena Baldissera,Corrado Campochiaro,Giulio Cavalli,Lorenzo Dagna,Giacomo De Luca,Emanuel Della Torre,Alessandro Tomelleri,Davide Bernasconi De Luca,Amedeo F. Capetti,Massimo Coen,Maria V. Cossu,Massimo Galli,Andrea Giacomelli,Guido A. Gubertini,Stefano Rusconi,Giulia Burastero,Margherita Digaetano,Giovanni Guaraldi,Marianna Meschiari,Cristina Mussini,Cinzia Puzzolante,Sara Volpi,Marina Aiello,Alarico Ariani,Alfredo Chetta,Annalisa Frizzelli,Andrea Ticinesi,Domenico Tuttolomondo,Stefano Aliberti,Francesco Blasi,Marta F. Di Pasquale,Sofia Misuraca,Tommaso Pilocane,Edoardo Simonetta,Alessio M. Aghelmo,Claudio Angelini,Enrico Brunetta,Giorgio Walter Canonica,Michele Ciccarelli,Sara Dal Farra,Maria De Santis,Sebastian Ferri,Marco Folci,Giacomo Maria Guidelli,Enrico Heffler,Ferdinando Loiacono,Giacomo Malipiero,Giovanni Paoletti,Rosa Pedale,Francesca A. Puggioni,Francesca Racca,Aurora Zumbo,Morihiko Satou,Tatyana Lisun,Denis Protsenko,Nikolay Rubtsov,Irina Beloglazova,Daria Fomina,Mariana Lysenko,Sofia Serdotetskova,Vitali Firstov,Ivan Gordeev,Ilia Kokorin,Ksenia Komissarova,Nina Lapochkina,Elena Luchinkina,Valentin Malimon,Sevinch Mamedguseyinova,Ksenia Polubatonova,Natalia Suvorova,Jose R. Arribas,Alberto M. Borobia Perez,Fernando de la Calle Prieto,Juan Carlos Figueira,Rocio Motejano Sanchez,Marta Mora-Rillo,Concepcion Prados Sanchez,Javier Queiruga Parada,Francisco Fernandez Arnalich,Maria Guerro Barrientos,Alejandro Bendala Estrada,Aranzazu Caballero Marcos,Maria E. Garcia Leoni,Rita García-Martínez,Ana María Collado,Patricia Munoz Garcia,Ana Torres do Rego,Maria Garcia,Almudena Burrillo,Maricela Valerio Minero,Paloma Gijon Vidaurreta,Sonsoles Infante Herrero,Elena Velilla,Marina Machado,María Olmedo,Blanca Pinilla,Benito Almirante Gragera,Maria de la Esperanza Cañas Ruano,Sofia Contreras Medina,Alejandro Cortés Herrera,Vicenç Falcó Ferrer,Ricard Ferrer Roca,Xavier Nuvials Casals,Esteve Ribera Pascuet,Paula Suanzes Diez,Pedro Rebollo Castro,Felipe Garcia Alcaide,Alejandro Soriano,Aina Oliver Caldes,Ana González Cordón,Celia Cardozo,Lorena De la Mora Cañizo,Romina Pena López,Sandra Chamorro,Clara Crespillo-Andujar,Rosa Escudero Sanchez,Jesús Fortún-Abete,Begoña Monge-Maillo,Ana Moreno Zamora,Francesca Norman,Matilde Sanchez Conde,Sergio Serrano Villar,Pilar Vizcarra +297 more
TL;DR: In this article, the authors evaluated the safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical(requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.
Journal ArticleDOI
Research needs in allergy: an EAACI position paper, in collaboration with EFA
Nikolaos G. Papadopoulos,Ioana Agache,Sevim Bavbek,B. M. Bilo,Fulvio Braido,Victoria Cardona,Adnan Custovic,Jan Demonchy,Pascal Demoly,Philippe Eigenmann,Jacques Gayraud,Clive Grattan,Enrico Heffler,Peter Hellings,Marek Jutel,Edward F. Knol,Jan Lötvall,Antonella Muraro,Lars K. Poulsen,Graham Roberts,Peter Schmid-Grendelmeier,Chrysanthi Skevaki,Massimo Triggiani,Ronald Vanree,Thomas Werfel,Breda Flood,Susanna Palkonen,Roberta Savli,Pia Allegri,Isabella Annesi-Maesano,Francesco Annunziato,Darío Antolín-Amérigo,Christian Apfelbacher,Miguel Blanca,Ewa Bogacka,Patrizia Bonadonna,Matteo Bonini,Onur Boyman,Knut Brockow,Peter Burney,Jeroen Buters,Indre Butiene,Moises A. Calderon,Lars-Olaf Cardell,Jean-Christoph Roger J-P Caubet,Sevcan Celenk,Ewa Cichocka-Jarosz,Cemal Cingi,Mariana Couto,Nicolette W. deJong,Stefano Del Giacco,Nikolaos Douladiris,Filippo Fassio,Jean-Luc Fauquert,Javier Fernández,Montserrat Fernandez Rivas,Marta Ferrer,Carsten Flohr,James Gardner,Jon Genuneit,Philippe Gevaert,Anna Groblewska,Eckard Hamelmann,Hans Jürgen Hoffmann,Karin Hoffmann-Sommergruber,Lilit Hovhannisyan,Valérie Hox,Frode L. Jahnsen,Ömer Kalayci,Ayse Fusun Kalpaklioglu,Jörg Kleine-Tebbe,George N. Konstantinou,Marcin Kurowski,Susanne Lau,Roger Lauener,Antti Lauerma,Kirsty Logan,Antoine Magnan,Joanna Makowska,Heidi Makrinioti,Paraskevi Mangina,Felicia Manole,Adriano Mari,Angel Mazon,Clare Mills,Ervinç Mingomataj,Bodo Niggemann,Gunnar Nilsson,Markus Ollert,Liam O'Mahony,Serena O'Neil,Gianni Pala,Alberto Papi,Gianni Passalacqua,Michael R. Perkin,Oliver Pfaar,Constantinos Pitsios,Santiago Quirce,Ulrike Raap,Monika Raulf-Heimsoth,Claudio Rhyner,Paula Robson-Ansley,Rodrigo Rodrigues Alves,Zeljka Roje,Carmen Rondon,Odilija Rudzeviciene,Franziska Ruëff,Maia Rukhadze,Gabriele Rumi,Cansin Sackesen,Alexandra F. Santos,Alexandra F. Santos,Annalisa Santucci,Christian Scharf,Carsten B. Schmidt-Weber,B Schnyder,Jürgen Schwarze,Gianenrico Senna,Svetlana Sergejeva,Sven Seys,Andrea Siracusa,Isabel Skypala,Milena Sokolowska,François Spertini,Radoslaw Spiewak,Aline B. Sprikkelman,Gunter J. Sturm,Ines Swoboda,Ingrid Terreehorst,Elina Toskala,Claudia Traidl-Hoffmann,Carina Venter,Berber Vlieg-Boerstra,Paul Whitacker,Margitta Worm,Paraskevi Xepapadaki,Cezmi A. Akdis +136 more
TL;DR: The present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.
Journal ArticleDOI
Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs
TL;DR: Human eosinophils were first identified and named by Paul Ehrlich in 1879 on the basis of the cell's granular uptake of Eosin this paper.