G
Gilbert R. Upchurch
Researcher at University of Florida
Publications - 525
Citations - 19791
Gilbert R. Upchurch is an academic researcher from University of Florida. The author has contributed to research in topics: Aortic aneurysm & Medicine. The author has an hindex of 68, co-authored 460 publications receiving 17175 citations. Previous affiliations of Gilbert R. Upchurch include Wayne State University & Brigham and Women's Hospital.
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Journal ArticleDOI
Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
Gilbert R. Upchurch,George N. Welch,Attila J. Fabian,Jane E. Freedman,Joseph L. Johnson,John F. Keaney,Joseph Loscalzo +6 more
TL;DR: It is shown that Hcy treatment of bovine aortic endothelial cells leads to a dose-dependent decrease in NO x independent of endothelial nitric-oxide synthase activity or protein levels and nos3 transcription, suggesting that HCy affects the bioavailability of NO, not its production.
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The care of patients with an abdominal aortic aneurysm: The Society for Vascular Surgery practice guidelines
Elliot L. Chaikof,David C. Brewster,Ronald L. Dalman,Michel S. Makaroun,Karl A. Illig,Gregorio A. Sicard,Carlos H. Timaran,Gilbert R. Upchurch,Frank J. Veith +8 more
TL;DR: Recommendations for evaluating the patient, including risk of aneurysm rupture and associated medical co-morbidities, guidelines for selecting surgical or endovascular intervention, intraoperative strategies, perioperative care, long-term follow-up, and treatment of late complications are provided.
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Epidemiology of aortic aneurysm repair in the United States from 2000 to 2010.
TL;DR: Lower mortality rates and shorter LOS despite a 27%-36% higher cost of care continues to justify the use of EVAR over OAR, and EVAR should be the preferred management of both ruptured and unruptured AAAs.
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Surgical treatment of intact thoracoabdominal aortic aneurysms in the United States: Hospital and surgeon volume-related outcomes
John A. Cowan,Justin B. Dimick,Peter K. Henke,Thomas S. Huber,James C. Stanley,Gilbert R. Upchurch +5 more
TL;DR: Given the relative high perioperative mortality associated with TAAA repair, regionalization of care to high-volume providers with consistently lower postoperative mortality deserves consideration by patients, physicians, and health care planners.
Journal ArticleDOI
Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study.
B. Timothy Baxter,William H. Pearce,Eugene A. Waltke,Fred N. Littooy,John W. Hallett,K. Craig Kent,Gilbert R. Upchurch,Elliot L. Chaikof,Joseph L. Mills,Beverly Fleckten,G. Matt Longo,Jason K. Lee,Robert W. Thompson +12 more
TL;DR: Prolonged administration of doxycycline is safe and well tolerated by patients with small asymptomatic AAAs and is associated with a gradual reduction in plasma MMP-9 levels, which is a biomarker of aneurysm disease progression.