Gilles Dietrich

TL;DR: Investigation of the mechanism of this analgesic action in mice revealed that this activity was mediated through local inhibition of nociceptor Nav channels, and suggested that topical amitriptyline could provide effective pain relief for chemotherapy-induced peripheral neuropathy patients without any systemic or local adverse events.

TL;DR: In this article, a novel antinociceptive strategy exploiting the opioid-mediated analgesic properties of T lymphocytes to relieve from bladder pain was proposed for interstitial cystitis/bladder pain.

TL;DR: In this article, the consequences of a peripheral opioid receptor blockade by naloxone-methiodide, a general opioid receptor antagonist unable to cross the blood-brain barrier, on the development of piroxicam-accelerated colitis in IL-10-deficient mice were examined.

TL;DR: In this article, the authors investigated the relationship between ER stress and serine protease activity in colitis-associated epithelial dysfunctions and its impact on intestinal functions. And they found that excessive ER stress in IECs caused an increased release of trypsin activity that, in turn, altered intestinal barrier function, then promoting the development of inflammatory process.