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Gilles Dietrich

Researcher at University of Toulouse

Publications -  77
Citations -  3188

Gilles Dietrich is an academic researcher from University of Toulouse. The author has contributed to research in topics: Autoantibody & Antibody. The author has an hindex of 30, co-authored 71 publications receiving 2798 citations. Previous affiliations of Gilles Dietrich include Centre national de la recherche scientifique & Université catholique de Louvain.

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Intestinal inflammation and pain management.

TL;DR: The review will focus on the endogenous immune-mediated regulation of visceral inflammatory pain, current pain treatments in inflammatory bowel diseases and prospectives on new opioid therapeutic opportunities to alleviate pain but avoiding common centrally-mediated side effects.
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Morphine-like Activity of Natural Human IgG Autoantibodies Is because of Binding to the First and Third Extracellular Loops of the μ-Opioid Receptor

TL;DR: The results suggest that the simultaneous binding of IgG antibodies to these two loops mimics morphine-induced receptor activation by triggering a coordinated shift of the third and sixth transmembrane helices.
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Mu and delta opioid receptor knockout mice show increased colonic sensitivity.

TL;DR: This work investigated whether mu (MOR) and delta (DOR) receptor endogenous activity assessed in the whole mouse body or in particular at peripheral receptors on primary nociceptive neurons, control colonic pain.