G
Gilles Dietrich
Researcher at University of Toulouse
Publications - 77
Citations - 3188
Gilles Dietrich is an academic researcher from University of Toulouse. The author has contributed to research in topics: Autoantibody & Antibody. The author has an hindex of 30, co-authored 71 publications receiving 2798 citations. Previous affiliations of Gilles Dietrich include Centre national de la recherche scientifique & Université catholique de Louvain.
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Journal ArticleDOI
A V region-connected autoreactive subfraction of normal human serum immunoglobulin G
TL;DR: The observations are suggestive of a tight control by IgG of the expressed autoreactive repertoire in healthy individuals and strengthen the concept that the therapeutic infusion of pooled normal IgG (IVIg) may be effective in autoimmune diseases by bringing to patients normal regulatory components of the immunoglobulin network.
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Selection of the expressed B cell repertoire by infusion of normal immunoglobulin G in a patient with autoimmune thyroiditis
TL;DR: It is suggested that normal IgG may modulate autoreactivity by selecting expressed antibody repertoire through V region‐dependent interactions with antibodies.
Journal ArticleDOI
Variable region-connected, dimeric fraction of intravenous immunoglobulin enriched in natural autoantibodies.
Tchavdar L. Vassilev,Ilina L. Bineva,Gilles Dietrich,Srinivas V. Kaveri,Michel D. Kazatchkine +4 more
TL;DR: It is suggested that therapeutic preparations of IVIg enriched in dimers may be obtained by size exclusion chromatography, following previous observations on enhanced autoantibody content of the affinity chromatography-separated 'connected' fraction ofIVIg.
Journal ArticleDOI
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.
Laurence Martin,Céline Augé,Céline Augé,Jérôme Boué,Jérôme Boué,Michelle Buresi,Kevin Chapman,Samuel Asfaha,Patricia Andrade-Gordon,Martin Steinhoff,Nicolas Cenac,Nicolas Cenac,Gilles Dietrich,Gilles Dietrich,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle +16 more
TL;DR: A previously unknown endogenous mechanism of analgesia is highlighted, showing a central role for the thrombin receptor PAR1 in the regulation of inflammatory pain and as an activator of opioid pathways.
Journal ArticleDOI
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Jérôme Boué,Jérôme Boué,Jérôme Boué,Catherine Blanpied,Catherine Blanpied,Catherine Blanpied,Marilena Djata-Cabral,Marilena Djata-Cabral,Marilena Djata-Cabral,Lucette Pelletier,Lucette Pelletier,Lucette Pelletier,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle,Gilles Dietrich,Gilles Dietrich,Gilles Dietrich +17 more
TL;DR: Investigation of mechanisms of opioid release by antigen‐experienced effector CD4+ T cells that leave draining lymph nodes and come back into the inflammatory site showed that analgesia induced by T cell‐derived opioids is elicited via activation of δ‐type opioid receptors in the periphery.