G
Gillian C. Lowe
Researcher at University Hospitals Birmingham NHS Foundation Trust
Publications - 48
Citations - 1296
Gillian C. Lowe is an academic researcher from University Hospitals Birmingham NHS Foundation Trust. The author has contributed to research in topics: Medicine & Platelet. The author has an hindex of 18, co-authored 42 publications receiving 991 citations. Previous affiliations of Gillian C. Lowe include University of Birmingham & Queen Elizabeth Hospital Birmingham.
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Journal ArticleDOI
Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders
TL;DR: The ISTH bleeding assessment tool (ISTH‐BAT) was developed to record bleeding symptoms and to aid diagnosis in patients with a possible bleeding disorder.
Journal ArticleDOI
Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects
Ben B. Johnson,Gillian C. Lowe,Jane Futterer,Marie Lordkipanidzé,David MacDonald,Michael A. Simpson,Isabel Sánchez-Guiu,Sian Drake,Danai Bem,Vincenzo C. Leo,Sarah J. Fletcher,Ban B. Dawood,José Rivera,David Allsup,Tina Biss,Paula H. B. Bolton-Maggs,Peter William Collins,Nicola Curry,Charlotte Grimley,Beki James,Michael Makris,Jayashree Motwani,Sue Pavord,Kate Talks,Jecko Thachil,Jonathan T. Wilde,Michael Williams,Paul Harrison,Paul Gissen,Stuart J. Mundell,Andrew D Mumford,Martina E. Daly,Steve P. Watson,Neil V. Morgan +33 more
TL;DR: The results demonstrate that whole exome sequencing is an efficient method for elucidating potential pathogenic genetic variants in inherited thrombocytopenia and has the added benefit of discovering potentially pathogenic Genetic variants for further study in novel genes not previously implicated in inheritedThROMbocy topenia.
Journal ArticleDOI
Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects
Jacqueline Stockley,Neil V. Morgan,Danai Bem,Gillian C. Lowe,Marie Lordkipanidzé,Ban B. Dawood,Michael A. Simpson,Kirsty Macfarlane,Kevin Horner,Vincenzo C. Leo,Kate Talks,Jayashree Motwani,Jonathan T. Wilde,Peter William Collins,Michael Makris,Steve P. Watson,Martina E. Daly +16 more
TL;DR: Analysis of candidate platelet function disorder genes in 13 index cases with a history of excessive bleeding in association with a significant reduction in dense granule secretion and impaired aggregation to a panel of platelet agonists suggests alterations in FLI1 and RUNX1 may be common in patients with platelet dense granules secretion defects and mild thrombocytopenia.
Journal ArticleDOI
Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel
Ban B. Dawood,Gillian C. Lowe,Marie Lordkipanidzé,Danai Bem,Martina E. Daly,Michael Makris,Andrew D Mumford,Jonathan T. Wilde,Steve P. Watson +8 more
TL;DR: Most PFDs can be reliably diagnosed using a streamlined panel of key platelet agonists and specified concentrations suitable for testing in most clinical diagnostic laboratories, and it is demonstrated that most LTA or ATP secretion test results were identified in 58% of participants.
Journal ArticleDOI
Practical guidance for the management of adults with immune thrombocytopenia during the COVID-19 pandemic.
Sue Pavord,Jecko Thachil,Beverley J. Hunt,Michael F. Murphy,Gillian C. Lowe,Michael Laffan,Michael Makris,Adrian C. Newland,Drew Provan,John D. Grainger,Quentin A. Hill +10 more
TL;DR: This document aims to provide practical guidance for the assessment and management of patients with thrombocytopenia during the COVID‐19 pandemic, with a particular focus on immune throm bocy topenia (ITP), during the coagulation disorders pandemic.