I
Ilaria Iacobucci
Researcher at St. Jude Children's Research Hospital
Publications - 41
Citations - 3155
Ilaria Iacobucci is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 14, co-authored 41 publications receiving 2258 citations. Previous affiliations of Ilaria Iacobucci include University of Bologna & University of New Mexico.
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Journal ArticleDOI
Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia
Kathryn G. Roberts,Yongjin Li,Debbie Payne-Turner,Richard C. Harvey,Yung-Li Yang,Dehua Pei,Kelly McCastlain,Li Ding,Li Ding,Changxue Lu,Changxue Lu,Guangchun Song,Jing Ma,Jared Becksfort,Michael Rusch,S. C. Chen,John Easton,J. Cheng,Kristy Boggs,Natalia Santiago-Morales,Ilaria Iacobucci,Robert S. Fulton,Robert S. Fulton,Ji Wen,Marcus B. Valentine,Cheng Cheng,Steven W. Paugh,Meenakshi Devidas,Meenakshi Devidas,I-Ming Chen,S. Reshmi,S. Reshmi,Amy Smith,Erin Hedlund,Pankaj Gupta,Panduka Nagahawatte,Gang Wu,Xiang Chen,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Naomi J. Winick,Eric Larsen,William L. Carroll,William L. Carroll,Nyla A. Heerema,Andrew J. Carroll,G. Grayson,Sarah K. Tasian,Andrew S. Moore,F. Keller,Melissa Frei-Jones,J. A. Whitlock,Elizabeth A. Raetz,Deborah L. White,Timothy P. Hughes,J. M. Guidry Auvil,Malcolm A. Smith,Malcolm A. Smith,Guido Marcucci,Clara D. Bloomfield,Krzysztof Mrózek,Jessica Kohlschmidt,Jessica Kohlschmidt,Wendy Stock,Steven M. Kornblau,Marina Konopleva,Elisabeth Paietta,Ching-Hon Pui,Sima Jeha,Mary V. Relling,William E. Evans,Daniela S. Gerhard,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Elaine R. Mardis,Richard K. Wilson,Mignon L. Loh,Mignon L. Loh,James R. Downing,James R. Downing,Stephen P. Hunger,Stephen P. Hunger,Cheryl L. Willman,Cheryl L. Willman,Jinghui Zhang,Charles G. Mullighan,Charles G. Mullighan +87 more
TL;DR: Ph-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors.
Journal ArticleDOI
Genetic Basis of Acute Lymphoblastic Leukemia
TL;DR: A concise review of genomic studies in ALL is provided and the role of genomic testing in clinical management is discussed, to improve diagnosis, monitoring of residual disease, and early detection of relapse and to guide precise therapies.
Journal ArticleDOI
High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Kathryn G. Roberts,Zhaohui Gu,Debbie Payne-Turner,Kelly McCastlain,Richard C. Harvey,I-Ming Chen,Deqing Pei,Ilaria Iacobucci,Marcus B. Valentine,Stanley Pounds,Lei Shi,Yongjin Li,Jinghui Zhang,Cheng Cheng,Alessandro Rambaldi,Manuela Tosi,Orietta Spinelli,Jerald P. Radich,Mark D. Minden,Jacob M. Rowe,Selina M. Luger,Mark R. Litzow,Martin S. Tallman,Peter H. Wiernik,Ravi Bhatia,Ibrahim Aldoss,Jessica Kohlschmidt,Krzysztof Mrózek,Guido Marcucci,Clara D. Bloomfield,Wendy Stock,Stephen Kornblau,Hagop M. Kantarjian,Marina Konopleva,Elisabeth Paietta,Cheryl L. Willman,Charles G. Mullighan +36 more
TL;DR: Ph-like ALL is a highly prevalent subtype of ALL in adults and is associated with poor outcome, and trials comparing the addition of tyrosine kinase inhibitors to conventional therapy are required to evaluate the clinical utility of these agents in the treatment of Ph- like ALL.
Journal ArticleDOI
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
Jinghui Zhang,Kelly McCastlain,Hiroki Yoshihara,Beisi Xu,Yunchao Chang,Michelle L. Churchman,Gang Wu,Yongjin Li,Lei Wei,Ilaria Iacobucci,Yu Liu,Chunxu Qu,Ji Wen,Michael N. Edmonson,Debbie Payne-Turner,Kerstin B. Kaufmann,Shin-ichiro Takayanagi,Shin-ichiro Takayanagi,Erno Wienholds,Esmé Waanders,Esmé Waanders,Panagiotis Ntziachristos,Sofia Bakogianni,Jingjing Wang,Iannis Aifantis,Iannis Aifantis,Kathryn G. Roberts,Jing Ma,Guangchun Song,John Easton,Heather L. Mulder,Xiang Chen,Scott Newman,Xiaotu Ma,Michael Rusch,Pankaj Gupta,Kristy Boggs,Bhavin Vadodaria,James Dalton,Yanling Liu,Marcus L Valentine,Li Ding,Charles Lu,Robert S. Fulton,Lucinda Fulton,Yashodhan Tabib,Kerri Ochoa,Meenakshi Devidas,Deqing Pei,Cheng Cheng,Jun J. Yang,William E. Evans,Mary V. Relling,Ching-Hon Pui,Sima Jeha,Richard C. Harvey,I-Ming L. Chen,Cheryl L. Willman,Guido Marcucci,Clara D. Bloomfield,Jessica Kohlschmidt,Krzysztof Mrózek,Elisabeth Paietta,Martin S. Tallman,Wendy Stock,Matthew C. Foster,Janis Racevskis,Jacob M. Rowe,Selina M. Luger,Steven M. Kornblau,Sheila A. Shurtleff,Susana C. Raimondi,Elaine R. Mardis,Richard K. Wilson,John E. Dick,Stephen P. Hunger,Mignon L. Loh,James R. Downing,Charles G. Mullighan +78 more
TL;DR: A unique paradigm of transcription factor deregulation in leukemia is illustrated in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function.
Journal ArticleDOI
The genetic basis and cell of origin of mixed phenotype acute leukaemia
Thomas B. Alexander,Thomas B. Alexander,Zhaohui Gu,Ilaria Iacobucci,Kirsten Dickerson,John K. Choi,Beisi Xu,Debbie Payne-Turner,Hiroki Yoshihara,Mignon L. Loh,John T. Horan,Barbara Buldini,Giuseppe Basso,Sarah Elitzur,Valerie de Haas,C. Michel Zwaan,Allen Eng Juh Yeoh,Dirk Reinhardt,Daisuke Tomizawa,Nobutaka Kiyokawa,Tim Lammens,Barbara De Moerloose,Daniel Catchpoole,Hiroki Hori,Anthony V. Moorman,Andrew S. Moore,Ondrej Hrusak,Soheil Meshinchi,Soheil Meshinchi,Etan Orgel,Meenakshi Devidas,Michael J. Borowitz,Brent L. Wood,Nyla A. Heerema,Andrew Carrol,Yung-Li Yang,Malcolm A. Smith,Tanja M. Davidsen,Leandro C. Hermida,Patee Gesuwan,Marco A. Marra,Yussanne Ma,Andrew J. Mungall,Richard A. Moore,Steven J.M. Jones,Marcus B. Valentine,Laura J. Janke,Jeffrey E. Rubnitz,Ching-Hon Pui,Liang Ding,Yu Liu,Jinghui Zhang,Kim E. Nichols,James R. Downing,Xueyuan Cao,Lei Shi,Stanley Pounds,Scott Newman,Deqing Pei,Jaime M. Guidry Auvil,Daniela S. Gerhard,Stephen P. Hunger,Hiroto Inaba,Charles G. Mullighan +63 more
TL;DR: A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.