G
Giovanni Cassani
Researcher at Vita-Salute San Raffaele University
Publications - 70
Citations - 3282
Giovanni Cassani is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Affinity chromatography & Monoclonal antibody. The author has an hindex of 22, co-authored 70 publications receiving 3242 citations. Previous affiliations of Giovanni Cassani include University of Brescia.
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Journal ArticleDOI
Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure
Roberto Ferrari,Tiziana Bachetti,Roberta Confortini,Cristina Opasich,Oreste Febo,Angelo Corti,Giovanni Cassani,Odoardo Visioli +7 more
TL;DR: Measurement of sTNF-Rs, in addition to antigenic and bioactive TNF-alpha, is essential for evaluation of the activation of this cytokine in CHF and might inhibit the in vitro cytotoxicity of T NF-alpha.
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The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.
Ettore Appella,Elizabeth A. Robinson,Ullrich Sj,M P Stoppelli,Angelo Corti,Giovanni Cassani,Francesco Blasi +6 more
TL;DR: The area within ATF responsible for specific receptor binding has now been identified by the ability of different synthetic peptides corresponding to different regions of the amino terminus of uPA to inhibit receptor binding of 125I-labeled ATF.
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Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.
M P Stoppelli,Angelo Corti,Adolfo Soffientini,Giovanni Cassani,Francesco Blasi,Richard K. Assoian +5 more
TL;DR: An important role for urokinase in monocyte/macrophage biology is suggested: the native enzyme binds to the cells with the amino-terminal domain; the catalytic, carboxyl- terminal domain remains exposed on the cell surface to stimulate localized proteolysis and facilitate cell migration.
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Autocrine saturation of pro-urokinase receptors on human A431 cells.
M. Patrizia Stoppelli,Carlo Tacchetti,M. Vittoria Cubellis,Angelo Corti,Vincent J. Hearings,Giovanni Cassani,Ettore Appella,Francesco Blasi +7 more
TL;DR: It is proposed that the synthesis of uPA and uPA receptor by the same cell may provide a pathway for the activation of the metastatic potential of malignant cells.
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Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.
TL;DR: Secreted pro-uPA can find its way to the specific surface receptor without previous conversion to the two-chain form and that, once bound, can be activated by plasmin.