Giovanni Nigita

TL;DR: It is found that tRNA-derived small RNAs (tsRNAs) are dysregulated in many cancers and that their expression is modulated during cancer development and staging, and tsRNA-KO cells display a specific change in gene-expression profile, suggesting tsRNAs could be key effectors in cancer-related pathways.

TL;DR: The results show that tsRNAs are dysregulated in human cancer.

TL;DR: The miRandola database as mentioned in this paper contains 2132 entries with 581 unique mature miRNAs and 21 types of samples, which are classified into four categories: miRNA-Ago2 (173 entries), miRNA exosome (856 entries), MIRA-HDL (20 entries), and miRNA circulating (1083 entries).

TL;DR: An overview of ncRNAs, NGS technology, and the most recent/popular computational approaches and the challenges they attempt to solve are provided, which are essential to a more sensitive and comprehensive ncRNA annotation capable of furthering the authors' understanding of this still vastly uncharted genomic territory.

TL;DR: In this paper, the authors used droplet digital PCR (ddPCR) to detect hepatocellular carcinoma (HCC) using miRNAs with diagnostic potential in HCC patients, and their combinations were measured using Receiver Operating Characteristic (ROC) curve analyses.